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C&R E4 Flashcards

AKI Dialysis Drug Dosing CKD and Complications (77 cards)

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1
Q

Midodrine, indication?

A

intradialytic hypotension

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2
Q

Midodrine, Dosing?

A

2.5mg - 10mg PO 30min prior to HD

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3
Q

Vitamin E, indication?

A

cramping from dialysis

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4
Q

Vitamin E, dosing?

A

400 IU PO

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5
Q

Quinine, what not indicated for?

A

Leg cramps, FDA warning for no leg cramps

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6
Q

Opioids that are okay to use in kidney dysfunction

A

Fentanyl
Methadone

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7
Q

Opioids that are okay to use CAUTIOUSLY

A

Hydromorphone
Oxycodone
Hydrocodone

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8
Q

Opioids CONTRA in kidney dysfunction

A

Morphine
Codeine
Meperidine

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9
Q

Antimicrobial NOT ADJUSTED FOR THE KIDNEY

A

Azithromycin
Ceftriaxone
Clindamycin
Doxycline
Linezolid
Metronidazole
Moxifloxacin

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10
Q

Anticoags NOT ADJUSTED FOR THE KIDNEY

A

Warfarin
Heparin
Argatroban

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11
Q

Benazepril, brand name

A

Lotensin

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12
Q

Captopril, brand name

A

Capoten

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13
Q

Enalapril, brand name

A

Vasotec

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14
Q

Fosinopril, brand name

A

Monopril

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15
Q

Lisinopril, brand name

A

Zestril or Prinivil

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16
Q

Moexipril, brand name

A

Univasc

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17
Q

Quinapril, brand name

A

Accupril

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18
Q

Ramipril, brand name

A

Altace

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19
Q

Trandolopril, brand name

A

Mavik

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20
Q

All ACEi are dosed QD… except…

A

Captopril (Capoten) – TID
Enalapril (Vasotec) – BID

Think shorter duration of action

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21
Q

Azilsartan, brand

A

Edarbi

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22
Q

Candesartan, brand

A

Atacand

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23
Q

Eprosartan, brand

A

Teveten

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24
Q

Irbesartan, brand

A

Avapro

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25
All ARBs are dosed
QD
26
Losartan, brand
Coozar
27
Olmesartan, brand
Benicar
28
Telmisartan, brand
Micardis
29
Valsartan, brand
Diovan
30
RAASi DDI - AVOID, absolute contra
RAASi + NSAIDS --> AKI RAASi + K+ Supp --> Hyperkalemia RAASi + RAASi --> AKI and Hyperkalemia
31
Quinapril has ---- and can not be used with ---- and ----
Has Mg, can't be used with fluroquinolones and tetracyclines
32
RAASi DDI -- Caution
K sparing diuretics/aldosterone antagonist --> Hyperkalemia Li --> increase Li concentrations
33
RAASi Contraindications for use - ABSOLUTE
Pregnancy Bilateral renal artery stenosis hx of ACE/ARB related angioedema
34
RAASi Contraindications for use - Caution
Unilateral renal artery stenosis Hyperkalemia Dehydration/hypovolemia Hypotension Kidney Dysfunction (serum creatinine greater than 3)
35
Tsat is ...
functional iron
36
Serum Ferritin is...
storage iron
37
Hold IV iron for pt's with ...
Tsat > 50% Serum Ferritin >1200 ml
38
Iron Products (PO) DDI, impacting iron Absp, decrease iron absp
Tetracyclines, H2 antagonist, calcium carbonate, antacids, PPI, cholestyramine
39
Iron Products (PO) DDI, drugs impacted by Iron
Fluroquinolone, levothyroxine, tetracycline, mycophenolate, methyldopa, levodopa
40
Sevelamer carbonate, brand and why use?
Renvela, # 1 non ca binder (normal to high ca)
41
Lanthanum carbonate, brand and why use?
Fosrenol, chewable non ca binder (normal to high ca)
42
Ferric citrate, brand and why use?
Auryxia, iron deficiency anemia, non ca binder (normal to high ca)
43
Sucroferric oxyhydroxide, brand and why use?
Velphoro, pill burden, normal to high non ca binder
44
Calcium acetate, brand and why use?
PhosLo, #1 ca binder (low ca levels)
45
calcium carbonate, brand and why use?
No brand name, cheaper ca binder (low ca levels) but higher risk of hypercalemia
46
SGLT2i contra
Type 1 dm
47
SGLT2i monitor
Gential mycotic infections Fournier's gangrene Euglycemia DKA
48
Sglt2 gfr must be....for initiation?
Greater than 20 Gfr 4 is greater than 15 to 30 Gfr 5 is less than 15
49
Finerenone gfr must be ....for initation
Greater than 25 for initiation Gfr 4 is greater than 15 to 30 Gfr 5 is less than 15
50
Finerenone K must be...
Less than 5.5
51
Anemia baseline goals Hgb Ferritin Tsat
10-11 <500 >30%
52
iron PO and drugs ddi OR Ca based phos binders and drugs ddi, seperate by....
2hrs
53
Ferric gluconate brand
Ferrlecit
54
Iron sucrose brand
Venofer
55
Ferric gluconate dosing
125mg TIW x 8 doses
56
Iron sucrose dosing
100mg 1 - 3 times a week Total 1g
57
Epoetin alpha brand
Epogen
58
Darbepoetin alpha brand
Aranesp
59
Methoxy polyethylene glycol epoetin beta brand
Mircera
60
Shortest to longest duration of action epo
Epogen (TIW) Aranesp (1 wk) Mircera (2 wks)
61
ESA Ade
Hypertension Hypercoagulability with an increased risk of thrombosis (Thromboembolism and Stroke) Malignancy Pure red blood cell aplasia
62
All phos binders DDI with...
Fluoroquinolones Levothyroxine Iron (The iron-based ones don't ddi with iron obvi)
63
Non Ca based phos binder ADE and DDI Think drug class
Sevelamer: GI upset and diarrhea Lanthanum: GI upset other rx need to be 1hr prior or 3 hrs after (since phos binding will have DDI)
64
Iron based phos binder ADE
Ferric Citrate ADE: GI, diarrhea, iron overload, stool discolouration Sucroferic (Velphro): GI, diarrhea
65
Vitamin D Analogs in tpx flowchart
Doxercalciferol Pericalcitol
66
What is active vitamin D
1,25 - OH D3 (Calcitriol)
67
Vitamin D2
Ergocalciferol
68
Vitamin D3
Cholecalciferol
69
Calcifediol indication
Approved for MBD in CKD 3 and 4, not ESRD
70
Cinacalcet brand
Sensipar
71
Cinacalcet (Sensipar) indication
calcimimetic therapy
72
Cinacalcet (Sensipar) dosing
30mg/day PO and titrate up every 2 - 4 weeks to MDD 180mg
73
Cinacalcet (Sensipar) Pearls
treat Ca if < 8.4
74
Cinacalcet (Sensipar) ADE
N/V Hypocalcemia -- need to monitor within 1 wk and then monthly QTc prolongation and ventricular arrhythmias
75
Etelcalcetide brand name?
Parsabiv
76
Etecalcetide indication?
2nd line calcimimetic THAT IS GIVEN IV AT HD
77
Which iron therapy needs a 25mg testing dose?
Iron dextran

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