C10. Carbapenems, monobactams, beta lactamases Flashcards Preview

pharmacology > C10. Carbapenems, monobactams, beta lactamases > Flashcards

Flashcards in C10. Carbapenems, monobactams, beta lactamases Deck (10):
1

Carbapenems
Mention 1st and 2nd generation drugs

1st generation:
Ertapenem
2nd generation:
impienem
meropenem
doripenem

2

mechanism of carbapenems
Resistant to ?

cell wall synthesis inhibitors
Resistant to beta lactamases

3

spectrum of carbapenems

Gram + aerboic Yes
Gram + anerobic Yes
Gram - aerobic Yes
Gram - anaerboic yes

Gram positive cocci gram negative rods (enterobacter and pseudomonas spp.) and anerobs.

Broad spectrum- bactericidal:
Includes pseudomonas, acinetobacter, penicillin resistant pneumococci, enterococcus faecalis and B frailis
Not active against MRSA/E and more.



4

Kinetics of carbapenems:

enters CNS
kidney elimination
Imipenem is given with cilastatin, a dihydropeptidase inhibitor (to prevent inactiveion in the kidneys).

5

administration of cabapenems

PArental only, 3x4 times a day

6

Indications of carbapenems:

hospital infections
multimicrobial infections
Infections with unknown cause
sepsis

7

adverse effects of carbapenemes

GI symptoms, pseudomembrenous colitis
allergy, seizures (imipenem).
Allergy

8

Monobactam drug?

Aztreonam
Resistant to Beta lactamase
SAme mechanism as other beta lactamas

Uses:
IV drug mainly active versus gram negative rods
No cross allergenicity with penicilins or cephalosporins


Gram positive anerobic and anerobic = NO
Only work against gram negative aerobs

Given IV
Penetrates CNS


9

clinical use of monobactam

aztreonam

Pneumonia, meningitis, sepsis causeed by G- bacteria

10

Beta lactamase inhibitors

clavulanic acid, sulbactam, tazobactam

Amoxicillin+ clavulanic acid
Ampicillin Sulbactam
Piperacillin and tazobactam