Flashcards in Tetracyclin and glycylcyclines Deck (10):
What are tetracyclins?!
Cidic or static?
Broad or short spectrum?
PROTEIN SYNTHESIS INHIBITOR ANTIBIOTICS
Which tetracyclin drugs do you know?
Half life is different for the drugs!
Shoft acting: tetracycline, oxytetracycline
Medium acting methacycline
Long acting (36~ hours)- doxycycline).
chlorotetracycline, doxycycline, minocycline
bind reversibly to 30S subunit of the bacterial ribosomes, prevent the binding of the incoming charged tRNA,
inhibit protein synthesis in bacteria.
Broad spectrum with good activity versus
2) Vibrio infections (cholera).
4) Francisella tularensis
5) Atypical bacteria:
Spirochetes (all 3)
Gram + Anerob and anerobic = yes
Gram - anerob and anarob= yes
Other infections of such: bronchitis, pneumonia, UTI, and more.
resistance to tetracyclins
efflux pumps by gram - bacteria
Enzymatic inactivation by bacteria and proteins that intefere with the binding of the antibiotic to the ribosome.
kinetics of tetracyclins
Oral absorption mainly, tigercyclin is mainly used in the IV form.
Distribution to many organs such as kidney, gingiva, skin and more.
Does not cross BBB but does cross placenta!
Excretion is renal and liver
1) Tooth enemal dysplasia and possible reduction in bone growth in children
2) photosensitivity (demeclocycline and doxycycline)
3) GI distress- can lead to candiasis and enterocolitis
4) vestibular dysfunction (minocycline).
5) Liver dysfunction during pregnancy at high doses (contraindicated).
6) Kidney toxicitiy.
7) hypersensivity rxns
Generally not recommended below age of 8!!!
Pregnency is contraindicated due to entry to fluid.
what is doxycycline really good for?
what is demeclocycline really good for?
used in syndrome of inappropriate secretion of ADH (SIADH; blocks ADH receptor function in collecting ducts).