C3 Flashcards
proteins in granules of cytotoxic T cells
- Perforin 2.Granzymes 3.Granulysin
perforin
aids in delivering contents of granules into the cytoplasm of the target cell
has ability to control tumours & infections
Granzymes
Serine proteases, which activate apoptosis once in the cytoplasm of the target cell
Granulysin
has antimicrobial actions and can induce apoptosis
What passes through immunological synapses
Central suprapolarized active complex & granules
3 types of receptors NK cells
- Killer Immunoglobulin-like receptor (KIR)
- Heterodimeric C-lectin receptors (CD94 & NG2)
- Natural cytotoxicity receptors
(Tug of war: stimulation vs suppressors)
MHC-I on normal NK cells is recognised by
inhibitory receptors (inhibit signals from activating receptors) NK does not kill normal cell
Killing with cytotoxic T cells involves ___ induced when?
granules: induced after stimulation/ direct death signal
induce apoptosis
Name cytotoxic T cells effector molecules + other molecules involved
effector molecules: perforin, granzymes, granulysin, Fas ligand
others: IFNy, LTa, TNFa
which helper cell does IFNy come from
Th1 (macrophage activating effector molecules)
describe granulomas/ cysts
organised structure which seals off pathogen & starves of nutrients & O2
e.g. damage lungs TB/ brain Aspergillus infection
which part(s) of immune system is involved in cell-mediated immunology (CMI) & their recognition
innate - recognition: PAMPs with PRR
acquired - a.a sequence proteins: antibody-antigen bind
T cell receptor binding
CMI - effector responses
antibodies, soluble effectors, innate & aquired cells
name innate & acquired cell involved CMI
innate: NK, granulocytes, phagocytes, mast cells, basophils
Acquired: direct - cytotoxic T cells, indirect mediators - IFNy, tumour necrosis factor
phagocytes
engulf phathogen
