C3.1 Integration of body systems [done] Flashcards
System integration
- necessary process in living systems
- coordination is needed for component parts of a system to collectively perform an overall function
- all organisms use multiple systems to perform the various functions of life & within these systems there are interdependent subsystems that work to perform an overall function –> at every level in the functioning of an organism, there must be coordination btw & within systems [achieved by system integration]
*system integration depends on effective communication between components so they can interact [interactions: positive/ negative feedback OR can be complex & multifactorial w many loops and branches]
Hierarchy of subsystems integrated in a multicellular living organism: cells, tissues, organs, body systems
This integration is responsible for emergent properties [eg a cheetah becomes an effective predator by integration of its body systems]
In order for complex organisms to evolve to survive in their environments, it was necessary for cells to become specialised for certain functions
Groups of specialised cells –> specialised tissues
Groups of specialised tissues –> organs
Some organs evolved to work collectively to accomplish certain functions; Some organs –> body systems
Body systems are specialised for functions: obtaining nutrients, obtaining waste, reproduction. All of the body systems working in unison represent the entire organism
Emergent properties
Emergent properties are those that exist when the sum of all the parts creates features that do not exist within the individual components
- advantage of an organism level of complexity
- organism level of organisation results in a combination that is said to be greater than the sum of its parts
Nervous system VS endocrine system
Similarities:
1. both used for communication btw cells
2. both cause a response (stimulate/ inhibit processes) in target cells
3. hormones & neurotransmitters are both chemicals that bind to receptors
4. both can work over long distances in the body
5. both under overall control of the brain as the brain has a role in sending hormones and nerve impulses
6. both use negative feedback
Differences
1. hormones are chemical messengers while nerve impulses are electrical signals
2. hormones are transported in blood while nerve impulses are transported by neurons
3. hormones take a longer time to travel while nerve impulses travel faster
4. Hormones are carried throughout the body while nerve impulses are carried to a single/ specific cell/ muscle fibre
5. in the endocrine system, all/ a wide range of tissues/ organs are affected while in the nervous system, only muscles/ glands receive signals
6. Reponses in the endocrine system are USUALLY longterm/ persistent while the responses in nervous system are short-lived/ short duration
Role of blood system in transporting materials between organs
Most multicellular organisms have become so large that it is impossible for nutrients & waste products to be efficiently and directly moved from cell to cell
Examples of role of blood system (MUST KNOW)
1. transport vessels & aqueous fluids have evolved to serve that purpose
2. humans & many other animals use blood circulating in arteries & veins to transport a variety of substances throughout the body tissues
3. the oxygen needed by leg muscles will be supplied by blood that has received that oxygen from lung tissues a short time before it is used
4. urea produced as a by-product of protein metabolism in the liver will be transported by blood to the kidneys to be filtered out & become part of urine
Brain is the central information integration organ
The brain is the central integrating organ of our body
- it receives info –> processes it –> stores some of it & sends instructions to all parts of the body to coordinate life processes
- the info received by the brain comes from sensory receptors, both in specialised sense organs [eg eye] & from receptor cells in other organs [eg pressure receptors in blood vessels]
The brain can store information for the short-term/ longer term & sometimes for the rest of life
- Memory: capacity to store information [essential for learning]
- processing of info leads to decision making by the brain –> result in signals being sent to muscles or glands which cause these organs to carry out a response
Difference between unconscious VS conscious processes
- performed when awake/ asleep VS performed only when awake
- performed involuntarily [we do not have to think about the actions and cannot normally prevent them through thought] VS performed voluntarily [we can think about the action & decide whether or not to carry it out]
- secretion by glands & contractions of smooth muscle [not attached to bones] are unconscious & therefore involuntary VS contraction of striated muscle (attached to bones) can be done consciously & therefore voluntary
- coordinated by brain & spinal cord VS coordinated only by the cerebral hemisphere of the brain
- eg swallowing food once it has entered the oesophagus & vomiting when stomach contents are regurgitated VS eg initiation of swallowing when food is pushed from the mouth cavity into the pharynx
Central nervous system (CNS) & Peripheral nervous system (PNS)
The nervous system is made up of the CNS and PNS that connect the CNS to all other organs of the body
Two organs in the CNS: brain & spinal cord
PNS: cranial nerves, spinal nerves, ganglia outside CNS
Nervous System:
- CNS
- PNS –> somatic nervous system
–> autonomic nervous system
= sympathetic nervous system
= parasympathetic nervous system
*do not confuse effectors & receptors
- receptors: detect stimuli
- effectors: respond to stimuli
Sensory neurons pass impulses from receptor to CNS, motor neurons stimulate effectors (muscles/ glands)
Spinal cord is the integrating centre for unconscious processes
The spinal cord is located inside the vertebral column (backbone)
- pairs of spinal nerves branch off to the left & right between the vertebrae
Spinal cord has 2 main tissues:
1. White matter - containing myelinated (layer of fat/insulation that make the signals go faster) axons & other nerve fibres which convey signals from sensory receptors to the brain & from the brain to the organs of the body
2. Grey matter - containing cell bodies of motor neurons & interneurons with many synapses between these neurons
Synapses in the grey matter: used to process information & for decision-making so the spinal cord is also an integrating centre
The spinal cord only coordinates unconscious processes, esp reflexes; in some cases, it can do this more quickly than if signals were conveyed to and fro form the the brain
Sensory receptors
Sensory receptors:
- changes in the external environment can act as stimuli to the nervous system, if perceived by sensory receptors
- located in the skin & sense organs
- nerve endings of some sensory neurons act as receptors for touch & heat
- other stimuli are perceived by specialised receptor cells that pass impulses to sensory neurons [eg light-sensitive rod & cone cells in retina of eye]
There are also receptors inside the body that monitor internal conditions
- stretch receptors in striated muscle sense the state of contraction, allowing the brain to deduce the position of the body
- stretch receptors in the walls of arteries give a measure of blood pressure
- chemoreceptors in the walls of blood vessels detect whether concentrations of oxygen, carbon dioxide & glucose are low/ high
Sensory neurons convey messages from receptor cells to the CNS
Signals from all receptor cells & from nerve endings that perceive stimuli directly, are conveyed to the CNS by sensory neurons
- signals are in form of nerve impulses carried along the axons of sensory neurons
- these axons vary in length depending on the distance btw receptor cell & brain/ spinal cord
Brain receives all signals from the main sense organs located in the head: eyes, ears, nose & tongue
Spinal cord receives signals from other organs of the body including skin and muscles
Sensory inputs to the brain are received by specialised areas in the cerebral hemispheres
- the axons of sensory neurons enter either the spinal cord through one of the 31 pairs of spinal nerves, or the brain by one of the 12 pairs of cranial nerves
Motor neurons convey output from cerebral hemisphere to muscles
The cerebral hemispheres of the brain have a major role in the control of striated muscles & certain glands
- in particular, the primary motor cortex sends signals via motor neurons to each striated muscle in the body
Striated muscle is attached to the bone
- it is used for locomotion & controlling posture and it can be controlled consciously
- eg to stand up from a sitting position, signals are sent from parts of the motor cortex via motor neurons to muscles in the legs
The signals in motor neurons are nerve impulses
Structure of neurons
Grey matter of cerebral hemispheres contain: the cell body & dendrites of many motor neurons
- typically there are many dendrites, receiving signals from diff relay neurons & transmitting them to the cell body
One axon leads from the cell body out of the brain & down the spinal cord –> there it forms a synapse with a second motor neuron, whose axon leads to one specific striated muscle [the axons of these two motor neurons may in total extend to a metre or more, depending on the location of the muscle]
The axons of motor neurons are bundled up in nerves, often tgt with the axons of sensory neurons
- when a nerve impulse reaches the end of the axon, it stimulates the muscle fibres to contract & gland cells to secrete
Structure of nerves
*see slide 22 for reference
Nerves are bundles of nerve fibres of both sensory & motor neurons
- protective sheath, myelinated & unmyelinated nerve fibres
- nerves consist of the axons of multiple nerve cells
A neuron is an individual cell of the nervous system, whereas a nerve is a collection of neurons surrounded by a protective sheath
Neurons may be:
1. sensory neurons - carry action potentials from receptors to the CNS
2. motor neurons - carry action potentials from the CNS to a muscle
3. interneurons - located between sensory & motor neurons and are only found within the CNS
Neurons can be myelinated/ unmyelinated
- myelinated neurons have cells called SCHWANN CELLS wrapped around their axon & intervening areas where there are no Schwann cells [schwann cells produces myelin sheath]
* the areas btw Schwann cells are called NODES OF RANVIER
- the action potentials of myelinated axons are able to skip from one node of ranvier to the next, making transmission of the action potential much faster compared to unmyelinated axons
- groupings of myelinated & unmyelinated axons are surrounded by protective sheaths
*axon hillock decides whether or not the signal is fixed
Pain reflex arcs with a single interneuron in the grey matter of the spinal cord & a free sensory nerve ending in a sensory neuron as a pain receptor in the hand & skeletal muscle as the effector
A pain reflex arc is an example of an involuntary response & involves only 3 neurons
1. first of the neurons is a receptor neuron known as a nocireceptor/ pain receptor
eg if you accidentally hold a finger too close to an open flame –> results in nocireceptors located in skin of finger initiating afferent (sensory) action potentials –> action potentials travel through your hand & eventually join one of the spinal nerves
- after entering the spinal cord, the afferent neuron synapses with a short interneuron (also called relay neuron) located entirely within the grey matter of the spinal cord
- the interneuron synapses with a motor neuron & the resulting action potentials go directly to arm muscles (effector), which moves quickly to pull your finger away from the flame
The action of pulling your finger away from the source of pain occurs much faster than truly sensing the pain
- the reason for this is that the sensation of pain must travel to your cerebrum to be integrated by many neural synapses before a sensation is felt & a motor response formulated
The pain reflex arc has evolved to limit damage to body tissue by generating a quick reaction involving only 3 neurons
- the unusual aspect of this is that the reflex arc uses skeletal muscle as the effector, tissue that is normally innervated by the frontal lobe of the cerebrum
Role of cerebellum in coordinating skeletal muscle contraction & balance [overall control of movements of the body]
Although cerebellum is a v impt part of the brain associated with body movements, it does not initiate those movements.
The initiation of muscle contractions & thus body movements is accomplished by the MOTOR CORTEX of the cerebrum
- as soon as a movement begins, the cerebellum receives feedback impulses from the area of the body that is moving & many sense organs
- the cerebellum then sends out impulses to coordinate the movement –> results in smooth & balanced muscular activity, leading to coordinated movements
- cerebellum coordinates posture, balance, walking, hand & finger movements, eye movements, speech & much more
“Muscle memory” is more to do with training coordinated movements by the cerebellum than actually training muscle
Modulation of sleep patterns by melatonin secretion as a part of circadian rhythms [diurnal pattern of melatonin secretion by pineal gland & how it helps to establish a cycle of sleeping & waking]
A circadian rhythm is any pattern of behaviour/ physiology that is based on a 24-hour cycle
- the most obvious pattern of a circadian rhythm is our wake & sleep cycle
- many other organisms follow a circadian rhythm for sleep
Some animals like us are diurnal –> more active in daylight ours while other animals are nocturnal –> more active at night
Evidence suggests that the circadian rhythm is largely controlled/ modulated by a small endocrine gland: PINEAL GLAND
- located near the centre of brain between cerebrum & brainstem
- function is to produce a hormone: MELATONIN –> it regulates the sleep schedule
Studies have shown that melatonin levels are night during the night for diurnal animals & high during the day for nocturnal animals
Other studies have shown that light striking the retina of the eye inhibits melatonin production
Over a prolonged period of time our body become naturally regulated to a circadian rhythm that is only interrupted by atypical events
- eg travelling through several time zones in a short period of time –> jet lag
- eg extended viewing of television, mobile phones & computer screens in the evening –> alter natural circadian rhythm
Epinephrine (adrenaline) secretion by adrenal glands
When humans encounter a stressful situation, a hormone called EPINEPHRINE is released from ADRENAL GLANDS located on the upper/ superior side of each kidney
- epinephrine is released into the bloodstream –> resulting in numerous responses by the body
Epinephrine prepares us for fight-or-flight response [called this bc the body’s resources are called upon for immediate action in response to a threat/ other stimuli that require a vigorous & immediate response]
- intense muscle contractions & vigorous activity are facilitated by epinephrine release
- increased heart rate, blood glucose, breathing rate [fight-or-flight response]
Wide spread effects of epinephrine
- increasing heart rate & blood pressure
- increasing diameter of air passages –> more air received by lungs
- dilation of pupils of eyes –> see clearer
- increasing blood sugar levels by stimulating glycogen conversion to glucose in liver
- increasing blood supply to muscles
Hypothalamus
Area of the brain that acts as a link between nervous system & endocrine system
- contains receptors associated with autonomic nervous system functions –> receives action potentials from other areas of the body that also contain this type of receptor
- composed of both neurons & glandular cells
- glandular cells of hypothalamus produce hormones that either stimulate hormone release by the pituitary glands/ inhibit their release
Pituitary gland
Pituitary gland is referred often to as a singular gland, but it consists of two glands that exist as different “lobes”: Anterior & Posterior pituitary
- anterior & posterior lobes of the pituitary communicate with the hypothalamus in diff ways
- each secretes its own hormones
Majority of these hormones are chemical signals released into the bloodstream that regulate the homeostasis of various physiological factors (eg metabolic rate, reproductive cell formation, water balance)
Example: ADH
Antidiuretic hormones (ADH) produced by the hypothalamus is sent to the posterior pituitary & when needed is secreted by the posterior pituitary
- ADH controls homeostatic levels of water in body
Hypothalamus has specialised receptors: OSMORECEPTORS
- capable of sensing the water content of blood as it passes through the hypothalamus
- nerve impulses sent along the axons of neusecretory cells, causing secretion of ADH into bloodstream
If the water content is relatively low, the hypothalamus will send action potentials to the cells in posterior pituitary –> then the posterior pituitary secretes ADH into the blood stream
Target tissue of ADH is the collecting tubules of nephrons in the kidneys
- when the collecting tubules detect ADH, they reabsorb water that would have been released as part of urine
Many hormones (like ADH) work using a mechanism called negative feedback –> goal is to maintain homeostasis
- ADH & kidney function maintain a homeostatic level of water in the body
- if water in the body rises above homeostatic level, more urine is produced
- if water becomes too low, ADH is produced & water is reabsorbed before becoming part of urine
When ADH reaches the kidneys, ADH binds to membrane receptors –> leads to temporary increase in number of aquaporin molecules in the plasma membrane of distal tubules & collecting duct cells. More reabsorption of water gives rise to hyper osmotic urine, restoring blood plasma conc to normal
- alcohol is diuretic as it inhibits the release of ADH
Feedback control of heart rate
Changes to ventilation rate, body temperature & heart rate are brought back to set points by feedback control mechanisms
Eg when the body is “at rest”, the heart rate is under the control of the natural pacemaker within the heart –> sinoatrial (SA) node
- when u are active, muscle tissue requires additional oxygen & releases additional carbon dioxide as a result of increased rate of cell resp
- an increase in heart rate & stroke volume is required to carry the additional respiratory gases to and from the lungs
*Stroke volume = volume of blood pumped out of the heart w each ventricular contraction
Receptors known as baroreceptors & chemoreceptors can detect changes in the blood vessels & contents of the blood associated with an increase in the rate of cell respiration
Baroreceptors
Baroreceptors are sensitive to pressure changes in arterial blood vessels
When blood pressure increases, the wall of an artery is distended/ stretched outwards –> distention results in an increase in rate of action potentials sent to the medulla
- Medulla responds by sending impulses to the SA node (in the heart) to decrease the heart rate & force of contraction, leading to lower stroke volume
- when blood pressure falls below normal, a decrease in action potentials sent to the medulla will lead to an increase in heart rate & stroke volume
One location for BARORECEPTORS is on the arch of the aorta [largest artery in body is aorta & it forms an arch shape as it exits the left ventricle of the heart –> almost immediately, other major arteries begin to branch from the aortic arch]
- 2 of those major branches are the carotid arteries [carry oxygenated blood to head & brain] –> just before these 2 carotid arteries branch, they form an enlargement called a SINUS –> both carotid sinuses have baroreceptors on the walls of the blood vessels