Ca Drugs Flashcards
(21 cards)
Ca Carbonate
Chronic hypoCa Adolescents: 1300 mg Old: 1200 mg Most others: 1000 mg Greatest % Ca Take with food
Ca Citrate
Chronic hypoCa Adolescents: 1300 mg Old: 1200 mg Most others: 1000 mg B/w meals
Ca Gluconate
IV Severe acute hypoCa Adolescents: 1300 mg Old: 1200 mg Most others: 1000 mg
Furosemide
Loop diuretic
Up Ca excretion
Use for hypercalcemia
Cholecalciferol
D3
preferred agent because of modest cost and efficacy
70 yrs: 800 IU
Ergocalciferol
D2
Less efficient than D3
Calcifediol-25(OH)D3
Doesn’t require liver hydroxylation, so useful in liver disease
Calcifediol-25(OH)2 D3
best for patients with decreased synthesis of calcitriol (i.e. Vit D Dependent Ricket’s Type 1, chronic renal failure)
Alendronate
Bisphosphonates
1x/wk
Risedronate
Bisphosphonates
1x/wk
Zoledronate
Bisphosphonates
1x/yr
Bisphosphonates
Pyrophosphate analogs incorp in bone
Promote osteoclast apoptosis and inhibit fxn
First line in osteoporosis & hyperCa of malignancy
Bisphosphonates SE
GI, esophagitis, osteonecrosis of jaw
Raloxifine
SERM
SERMs
Selective Estrogen Receptor Modulators
Decreases osteoclast activity (induce OC apoptosis) & up OPG
2nd line osteoporosis. If can’t take bisphosphonates or invasive breast cancer.
SERM SE
hot flashes, leg cramps, risk of thromboembolic disorders
Teriparatide
PTH Analog - up osteoblastic act
$$$
SE: nausea, HA, dizziness, muscle pain
Miacalcin
Nasal calcitonin
Inhibit osteoclast bone resorption
Tx for osteoporosis
SE: Rhinitis and epistaxis
Denosumab
RANK-L Ab - prevent from activating OC
Pts at high risk for fractures or
unresponsive to bisphosphonates
Hydrochlorothiazide
Thiazide - decrease Ca excretion
For hypercalciuria
GC for Ca
Decrease Ca absorb, up Ca excretion.
For Chronic hypercalcemia
