Calcium Channel Blockers

Question 1

Drug class
Common indications (What is it used for?)
Mechanism of action (How does it work?)
Important adverse drug reactions we discussed
Important drug-drug interactions we discussed

Question 2

What class of drugs if amlodipine?

Answer 2

Dihydropyridine calcium channel blocker

Question 3

What is amlodipine used for?

Answer 3

Hypertension
Especially in low renin hypertension

Question 4

What Is amlodipine mode of action?

Answer 4

Blocks L type calcium Channel blocker (CCBs)
Prevents calcium entering the cell
preventing/ reducing vasoconstriction
more selective for peripheral vasculature
Target calcium initiated smooth muscle contractions

Question 5

What are the adverse effects of amlodipine?

Answer 5

Ankle swelling
Flushing and headaches
Palpitations
SNS activation

Question 6

DTDI of amlodipine

Answer 6

Simvastatin

Question 7

How is amlodipine administered

Answer 7

Good oral absorption

Question 8

Where is amlodipine metabolised

Answer 8

Liver

Question 9

How is amlodipine carried in the blood

Answer 9

Protein bound