Calculation Of Doses : General Considerations

Question 1

quantitative amount administered or taken by a patient for the intended medicinal effect.

Answer 1

Dose

Question 2

amount taken at one time.

Answer 2

Single Dose

Question 3

amount taken during the course of therapy.

Answer 3

Daily Dose/Total Dose

Question 4

schedule of dosing.

Answer 4

Dosage Regimen

Question 5

Example of Dosage Regimen

Answer 5

QID for 10 days

Question 6

amount that ordinarily produces the medicinal effect intended in the adult patient.

Answer 6

Usual Adult Dose

Question 7

amount that ordinarily produces the medicinal effect intended in infant or child patient.

Answer 7

Usual Pediatric Dose

Question 8

quantitative amounts of the drug that may be prescribed within the guidelines of usual medical practice.

Answer 8

Usual Dosage Range

Question 9

amount that produces the desired intensity of effect in 50% of the individuals tested.

Answer 9

Median Effective Dose

Question 10

amount that produces toxic effects in 50% of the individuals tested.

Answer 10

Median Toxic Dose

Question 11

Other term for Loading Dose

Answer 11

Priming Dose

Question 12

larger-than- usual initial dose may be required to achieve the desired blood drug level.

Answer 12

Loading Dose

Question 13

minimum concentration to produce the drug’s desired effects in a patient.

Answer 13

Median Effective Concentration (MEC)

Question 14

concentration that produces dose-related toxic effects.

Answer 14

Minimum Toxic Concentration (MTC)

Question 15

Primary Drug Treatment

Answer 15

Monotherapy

Question 16

Additional to or supportive of a different primary treatment.

Answer 16

Adjunctive Therapy

Question 17

Administered to protect the patient from contracting a specific disease.

Answer 17

Prophylactic Doses

Question 18

Example of Prophylactic Doses

Answer 18

Vaccines

Question 19

What does dosage forms contain?

Answer 19

Pharmaceutical ingredients

Question 20

What does pharmaceutical ingredients do?

Answer 20

• Provides physical features
• Stability Requirements
• Aesthetic Characteristics desiredfor optimal therapeutic dffects

Question 21

Enumerate Examples of Pharmaceutical Ingredients:

Answer 21

Solvents
Vehicles
Stabilizer
Solubilizers
Binders
Fillers
Disintegrants
Flavorants
Colorants

Question 22

What is the measuring device for that FDA stated that is not appropriate for giving medicines to children?

Answer 22

Kitchen teaspoon or Tablespoon

Question 23

Formula of number of doses?

Answer 23

Number of Doses = Total Quantity/Size of Dose

Question 24

Formula for Size of Dose

Answer 24

Size of Dose = Total Quantity/Number of Dozes

Question 25

Formula for total quantity

Answer 25

Total quantity = # of dose x size of dose

Question 26

If 1 tablespoon is prescribed as the dose, approximately how many doses will be contained in 1 pint of the medicine?

Answer 26

31.5 or 31 dose

Question 27

How many teaspoonfuls would be prescribed in each dose of an elixir if 180 mL contained 18 doses?

Answer 27

2 teaspoonfuls

Question 28

How many milliliters of a liquid medicine would provide a patient with 2 tablespoonfuls twice a day for 8 days?

Answer 28

480 mL

Question 29

The administration of doses that are much smaller than the usual dose of a drug.

Answer 29

LOW-DOSE THERAPY

Question 30

Examples of Low-Dose Therapy

Answer 30

- Aspirin 8 mg rather than 325 mg usual dose - Low-dose oral contraceptive use - Low-dose postmenopausal hormone therapy.

Question 31

administration of doses that are much larger than the usual dose of a drug.

Answer 31

HIGH-DOSE THERAPY

Question 32

Examples of High-Dose Therapy

Answer 32

- Chemotherapeutic treatment of cancer - High-Dose of Progestin for endometriosis - High-dose influenza vaccination for elderly

Question 33

If a patient is changed from a daily standard-dose postmenopausal product containing 0.625 mg of conjugated estrogens (CE) to a low-dose formulation containing 0.35 mg CE, how many milligrams less of CE would the patient take per week?

Answer 33

1.925 mg Conjugated Estrogens

Question 34

Products containing ____ or more ____________ ______ in Fixed Dose Combinations

Answer 34

Two, Therapeutic Agents

Question 35

Tell me if it is advantages or disadvantages of fixed-dosed combination. “Two or more needed drugs may be taken in a single dose”

Answer 35

Advantages

Question 36

Tell me if it is advantages or disadvantages of fixed-dosed combination. “Convenient, enhance compliance, less expensive”

Answer 36

Advantages

Question 37

Tell me if it is advantages or disadvantages of fixed-dosed combination. “Relative inflexibility in dosing compared with individual drug dosing”

Answer 37

Disadvantages

Question 38

A number of tablets are ________ , or _______, to allow breaking into approximately equal pieces (usually halves).

Answer 38

Scored or Grooved

Question 39

This allows **dosage flexibility**,particularly when a patient is started at a half dose and then is titrated up to a full dosage level.

Answer 39

Tablet Splitting and Crushing

Question 40

It also enables a patient to take a product at a strength that is not otherwise available.

Answer 40

Tablet Splitting and Crushing