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Micro > Campylobacter And Listeria > Flashcards

Campylobacter And Listeria Flashcards

1
Q

Reservoir for campylobacter jejuni/coli

A 
Poultry
Cattle
Pigs
Horses
Rabbits
Birds
Other animals
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2
Q

How much O2 and CO2 are required for campylobacter growth ?

A

Small amount of O2 (3-6%)
10% Co2

Campylobacter is microaerophilic

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3
Q

Chronic sequence that are caused by campylobacter

A

Reactive arthritis

Guillain Barre syndrome (acute flaccid paralysis )

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4
Q

Most commonly reported bacterial cause of foodborne illness in the US

A

Campylobacter

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5
Q

What are the reservoirs for Campylobacter jejuni

A 
Rabbits 
Rodents 
Birds 
Sheep
Horses 
Cows 
Pigs 
Poultry ***
Many animals
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6
Q

Outbreaks in the cause of Campylobacter jejuni is

A

Rare and most cases are sporadic

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7
Q

70% of cases of Campylobacter jejuni disease is

A

Consumption of contaminated or improperly cooked poultry

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8
Q

Minimum temp for growth of C.jejuni

A

30 C

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9
Q

C.jejuni is able to grow at

A

42 C

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10
Q

C.jejuni survival outside of the gut is

A

Poor

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11
Q

Campylobacteriosis incubation time

A

2-5 days

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12
Q

Campylobacteriosis duration

A

7-10 days ( relapses 25%)

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13
Q

Campylobacteriosis infectious dose

A

100-500 cells

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14
Q

Campylobacteriosis mortality rate

A

Rare <0.03%

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15
Q

Campylobacteriosis symptoms

A

Diarrhea
Fever
Abdominal cramping
Sometimes : bloody diarrhea, nausea, vomiting

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16
Q

Campylobacteriosis less frequently symptoms

A

Bacteremia( mostly in immuno compromised)
Septic arthritis
Extra intestinal symptoms

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17
Q

Pathogenicity of Campylobacteriosis

A

Can result in eterotoxigenic like illness with watery diarrhea

Can result in inflammatory colitis with fever and fecal blood and occasionally bacteremia that suggests an invasive mechanism

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18
Q

Virulence factor for C. Jejuni

A 
Health of host 
Age of host 
Flagella aid in attachment followed by
Host cell invasion
Toxin production 
Epithelial cell disruption and leakage
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19
Q

Complications of C.Jejuni

A 
Arthritis 
Carditis, endocarditis 
Meningitis 
Septicemia 
GBS
20
Q

What is GBS

A

Acute demyelination polyneuropathy Rapid onset of numbness,pain, and progressive weakness or paralysis

21
Q

How many percent of GBS patients had C.Jejuni

A

20-40%

22
Q

GBS attributes to autoimmune response to

A

Bacterial N-acetyl glucosamine antigens

23
Q

GBS has core oligosacharides structure that mimics

A

Ganglioside structures of the motor neurons

24
Q

Listeria monocytogenes is gram

A

+

25
Q

Listeria monocytogenes is psychotropic that means

A

They can grow in cold environment

26
Q

Listeria monocytogenes is a zero tolerance in

A

Ready to eat foods

27
Q

How many serotypes does Listeria monocytogenes have

A

13

28
Q

The most common LM serotypes that causes human disease

A

4b

29
Q

Symptoms of listeriosis

A

Flu like symptoms

30
Q

Complications for listeriosis

A 
Meningitis 
Miscarriage 
Stillbirth
Septicemia 
Mild gastroenteritis
31
Q

Why is listeriosis atypical foodborne disease ? Why is it different than other foodborne diseases

A 
Severity and non-enteric nature 
High fatality rate ( 20-30%)
Long incubation time (4d to weeks )
High risk of individuals who have underlying problems that affect T cell mediated immunity 
Manifestations are host dependent
32
Q

Mortality rate of listeriosis in immunocompromised and elderly

A

20-40%

33
Q

Clinical symptoms of listeriosis in healthy adults

A

GI symptoms

34
Q

Clinical symptoms of listeriosis in pregnant women

A 
Fever 
Muscle aches 
Diarrhea 
Premature delivery 
Still birth
35
Q

Clinical symptoms of listeriosis in newborns

A

Meningitis
Pneumonia
Fever

36
Q

Clinical symptoms of listeriosis in immunocompromised adults

A

Meningitis, blood infection

37
Q

Virulent listeria species

A

Listeria monocytogenes and

Listeria ivanovii

38
Q

This species of listeria is a foodborne concern

A

Listeria myocytogenes

39
Q

What conditions can predispose adults to complications of listeriosis

A 
Neoplasm
Aids
Alcoholism 
Pregnancy 
Diabetes 
CVD
Renal transplant 
Corticosteroid therapy
40
Q

LM bacteria can attach to host cells by

A

Internalins

Proteins that bind specifically to host cell

41
Q

What does LM produce in order to scape endosome and enter the cytoplasm ?

A

Listerolysin O (LLO)

42
Q

LM uses —–to move about the cell and into adjoins cells

A

Actin

43
Q

C. Jejuni is capnophilic which means

A

Thrive in high concentration of CO2

2-10%

44
Q

Symptoms of Listeriosis in pregnant women

A 
Flu like symptoms 
Abortion 
Fetal death 
Still birth
Severe neonatal septicemia 
Meningitis
45
Q

LM bacteria adhesion by

A

Internalins

Proteins that bind specifically to host cells

46
Q

Tetracycline resistant L monocytogenes from animal product may have obtained the tet gene from

A

Other gram positive bacteria in animal GI tract

Micro (9 decks)

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