Campylobacter And Listeria Flashcards Preview

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Flashcards in Campylobacter And Listeria Deck (46):
1

Reservoir for campylobacter jejuni/coli

Poultry
Cattle
Pigs
Horses
Rabbits
Birds
Other animals

2

How much O2 and CO2 are required for campylobacter growth ?

Small amount of O2 (3-6%)
10% Co2

Campylobacter is microaerophilic

3

Chronic sequence that are caused by campylobacter

Reactive arthritis
Guillain Barre syndrome (acute flaccid paralysis )

4

Most commonly reported bacterial cause of foodborne illness in the US

Campylobacter

5

What are the reservoirs for Campylobacter jejuni

Rabbits
Rodents
Birds
Sheep
Horses
Cows
Pigs
Poultry ***
Many animals

6

Outbreaks in the cause of Campylobacter jejuni is

Rare and most cases are sporadic

7

70% of cases of Campylobacter jejuni disease is

Consumption of contaminated or improperly cooked poultry

8

Minimum temp for growth of C.jejuni

30 C

9

C.jejuni is able to grow at

42 C

10

C.jejuni survival outside of the gut is

Poor

11

Campylobacteriosis incubation time

2-5 days

12

Campylobacteriosis duration

7-10 days ( relapses 25%)

13

Campylobacteriosis infectious dose

100-500 cells

14

Campylobacteriosis mortality rate

Rare <0.03%

15

Campylobacteriosis symptoms

Diarrhea
Fever
Abdominal cramping
Sometimes : bloody diarrhea, nausea, vomiting

16

Campylobacteriosis less frequently symptoms

Bacteremia( mostly in immuno compromised)
Septic arthritis
Extra intestinal symptoms

17

Pathogenicity of Campylobacteriosis

Can result in eterotoxigenic like illness with watery diarrhea

Can result in inflammatory colitis with fever and fecal blood and occasionally bacteremia that suggests an invasive mechanism

18

Virulence factor for C. Jejuni

Health of host
Age of host
Flagella aid in attachment followed by
Host cell invasion
Toxin production
Epithelial cell disruption and leakage

19

Complications of C.Jejuni

Arthritis
Carditis, endocarditis
Meningitis
Septicemia
GBS

20

What is GBS

Acute demyelination polyneuropathy Rapid onset of numbness,pain, and progressive weakness or paralysis

21

How many percent of GBS patients had C.Jejuni

20-40%

22

GBS attributes to autoimmune response to

Bacterial N-acetyl glucosamine antigens

23

GBS has core oligosacharides structure that mimics

Ganglioside structures of the motor neurons

24

Listeria monocytogenes is gram

+

25

Listeria monocytogenes is psychotropic that means

They can grow in cold environment

26

Listeria monocytogenes is a zero tolerance in

Ready to eat foods

27

How many serotypes does Listeria monocytogenes have

13

28

The most common LM serotypes that causes human disease

4b

29

Symptoms of listeriosis

Flu like symptoms

30

Complications for listeriosis

Meningitis
Miscarriage
Stillbirth
Septicemia
Mild gastroenteritis

31

Why is listeriosis atypical foodborne disease ? Why is it different than other foodborne diseases

Severity and non-enteric nature
High fatality rate ( 20-30%)
Long incubation time (4d to weeks )
High risk of individuals who have underlying problems that affect T cell mediated immunity
Manifestations are host dependent

32

Mortality rate of listeriosis in immunocompromised and elderly

20-40%

33

Clinical symptoms of listeriosis in healthy adults

GI symptoms

34

Clinical symptoms of listeriosis in pregnant women

Fever
Muscle aches
Diarrhea
Premature delivery
Still birth

35

Clinical symptoms of listeriosis in newborns

Meningitis
Pneumonia
Fever

36

Clinical symptoms of listeriosis in immunocompromised adults

Meningitis, blood infection

37

Virulent listeria species

Listeria monocytogenes and
Listeria ivanovii

38

This species of listeria is a foodborne concern

Listeria myocytogenes

39

What conditions can predispose adults to complications of listeriosis

Neoplasm
Aids
Alcoholism
Pregnancy
Diabetes
CVD
Renal transplant
Corticosteroid therapy

40

LM bacteria can attach to host cells by

Internalins

Proteins that bind specifically to host cell

41

What does LM produce in order to scape endosome and enter the cytoplasm ?

Listerolysin O (LLO)

42

LM uses -----to move about the cell and into adjoins cells

Actin

43

C. Jejuni is capnophilic which means

Thrive in high concentration of CO2
2-10%

44

Symptoms of Listeriosis in pregnant women

Flu like symptoms
Abortion
Fetal death
Still birth
Severe neonatal septicemia
Meningitis

45

LM bacteria adhesion by

Internalins

Proteins that bind specifically to host cells

46

Tetracycline resistant L monocytogenes from animal product may have obtained the tet gene from

Other gram positive bacteria in animal GI tract