Canadian Reference Guide

Question 1

Total daily dose range (mg) of Citalopram (Celexa)

Answer 1

20 - 60

Question 2

Dosing of Citalopram (Celexa)

Answer 2

od or qhs

Question 3

P450 Systems substrate of Citalopram (Celexa)

Answer 3

2C19, 3A4, 2D6

Question 4

P450 Systems Inhibits or Induce of Citalopram (Celexa)

Answer 4

NOTHING ;)

Question 5

Special considerations (Avoid, Caution, risk of) of Citalopram (Celexa)

Answer 5

1) Avoid MAOI’s or Ergot compounds
2) Risk SIADH (elderly)
3) Sexual dysfunction common, may be unreported

Question 6

T1/2 (hours) Citalopram (Celexa)

Answer 6

30

Question 7

Total daily dose range (mg) of Paroxetine (Paxil)

Answer 7

20 - 60

Question 8

Special considerations (Avoid, Caution, risk of) of Paroxetine (Paxil)

Answer 8

1) Avoid MAOI’s or Ergot compounds
2) Risk SIADH (elderly)
3) Sexual dysfunction common, may be unreported

Question 9

T1/2 (hours) of Paroxetine (Paxil)

Answer 9

30 - 65

Question 10

Dosing of Paroxetine (Paxil)

Answer 10

od (or qhs)

Question 11

P450 Systems substrate of Paroxetine (Paxil)

Answer 11

2D6

Question 12

P450 Systems Inhibits or Induce Paroxetine (Paxil)

Answer 12

2D6 (Inhibit)

Question 13

Total daily dose range (mg) of Sertraline (Zoloft)

Answer 13

50 - 200

Question 14

Total daily dose range (mg) of Fluoxetine (Prozac)

Answer 14

20 - 80

Question 15

Total daily dose range (mg) of Fluvozamine (Luvox)

Answer 15

100 - 300

Question 16

Total daily dose range (mg) of Venlafaxine XR (Effexor XR)

Answer 16

75 - 225

Question 17

Total daily dose range (mg) of Brupropion SR (Wellbutrin SR)

Answer 17

150 - 300

Question 18

Total daily dose range (mg) of Moclobemide (Manerix)

Answer 18

450 - 900

Question 19

Total daily dose range (mg) of Mirtazapine (Remeron)

Answer 19

30 - 60

Question 20

Total daily dose range (mg) of Amitriptyline (Elavil)

Answer 20

100 - 300

Question 21

Total daily dose range (mg) of Imipramine (Tofranil)

Answer 21

100 - 300

Question 22

Total daily dose range (mg) of Clomipramine (Anafranil)

Answer 22

100 - 300

Question 23

Total daily dose range (mg) of Nortriptyline (Aventyl)

Answer 23

75 - 200

Question 24

Total daily dose range (mg) of Desipramine (Norpramin)

Answer 24

100 - 300

Question 25

Total daily dose range (mg) of Phenelzine (Nardil)

Answer 25

30 - 90

Question 26

Total daily dose range (mg) of Tranylcypromine (Parnate)

Answer 26

20 - 80

Question 27

What is the total daily dose range for Citalopram (Celexa)?

Answer 27

20-60 ## Footnote This range indicates the typical dosage prescribed for effective treatment.

Question 28

What is the dosing schedule for Citalopram (Celexa) ?

Answer 28

Od or qhs ## Footnote 'Od' refers to once daily, and 'qhs' refers to at bedtime.

Question 29

What is the half-life (T1/2) of Citalopram (Celexa) in hours?

Answer 29

30 ## Footnote This indicates how long it takes for the concentration of the drug in the bloodstream to reduce by half.

Question 30

Which P450 systems does Citalopram (Celexa) act as a substrate for?

Answer 30

2C19, 3A4, 2D6 ## Footnote These are specific cytochrome P450 enzymes involved in drug metabolism.

Question 31

Does Citalopram (Celexa) inhibit or induce any P450 systems?

Answer 31

Nothing ;) ## Footnote This indicates that Citalopram does not affect the activity of these enzymes.

Question 32

What should be avoided when prescribing Citalopram (Celexa)?

Answer 32

MAOI's or Ergot compounds ## Footnote Combining these can lead to serious drug interactions.

Question 33

What is a special risk associated with Citalopram (Celexa) in the elderly?

Answer 33

Risk SIADH ## Footnote SIADH stands for Syndrome of Inappropriate Antidiuretic Hormone secretion, which can lead to hyponatremia.

Question 34

What common side effect may occur with Citalopram (Celexa) that is often unreported?

Answer 34

Sexual dysfunction ## Footnote This side effect can significantly affect a patient's quality of life but may not always be disclosed.