Cancer Flashcards
(21 cards)
the cells have a translocation of the c-MYC oncogene from the long arm of chromosome 8 on to heavy (H) chain immunoglobulin locus on chromosome 14.
MYC oncogene is translocated to regions of chromosome 2 ⇆22.
Burkitt lymphoma
ERBB2 also known as
HER 2
Mutations in p53 gene
Li Fraumeni syndrome
Mutations in p53 gene
Li Fraumeni syndrome
sarcomas, breast cancers,
tumors of the central nervous system,
leukemias at an increased frequency
decreased age compared with normal individuals.
Li fraumeni syndrome
Highly malignant childhood cancer of the developing retinal cells of the eye, usually occurring before 5 years of age.
Retinoblastoma
Retinoblastoma
The RB1 gene encodes a nuclear protein called p110RB, which associates with DNA and is involved in the regulation of the cell cycle.
The RB1 gene encodes a nuclear protein called p110RB, which associates with DNA and is involved in the regulation of the cell cycle.
Retinoblastoma
Non-hereditary cases usually involve only one eye,
whereas hereditary cases can be unilateral but are more commonly bilateral or multifocal in one eye.
Mutation APC gene
Familial adenomatous polyposis
Mutation VHL gene
Von hippel lindau syndrome
Mutation RET gene
Multiple endocrine neoplasia type 2
mutation in BRCA1
Breast ovarian cancer
Mutation in BRCA2
Breast cancer
Mutation in CDH1
Gastric cancer
Mutation in WT1
Wilms tumour
Mutation in NF1
Neurofibromatosis 1
Multiple adenomatous colon polyps
MYH GENE MYH POLYPOSIS
Juvenile polyposis syndrome
AD
SMAD4
BMPR1A
AD
STK11 gene mutation
Peutz Jegher syndrome
Cowden disease
Multiple hamartoma syndrome
PTEN
