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1 - MSRA > Cancer > Flashcards

Cancer Flashcards

(35 cards)

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1
Q

Aflatoxin (produced by aspergillus) causes?

A

Hepatocellular carcinoma

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2
Q

Aniline dyes causes?

A

Bladder TCC

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3
Q

Asbestos causes?

A

Mesothelioma and bronchial carcinoma

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4
Q

Nitrosamines causes?

A

Oesophageal and gastric cancer

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5
Q

Vinyl chloride causes?

A

Hepatic angiosarcomae

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6
Q

SEs cyclophosphamide

A

Haemorrhagic cystitis
Myelosuppression
TCC

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7
Q

SEs bleomycin

A

Lung fibrosis

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8
Q

SEs anthracyclines, e.g. doxorubicin

A

Cardiomyopathy

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9
Q

SEs methotrexate

A

Myelosupression
Mucositis
Liver fibrosis
Lung fibrosis

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10
Q

SEs 5-FU

A

Myelosuppression
Mucositis
Dermatitis

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11
Q

SEs 6-mercaptopurine

A

Myelosuppression

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12
Q

SEs cytarabine

A

Myelosuppression
Ataxia

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13
Q

SEs vincristine

A

Peripheral neuropathy
Paralytic ileus

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14
Q

SEs vinblastine

A

Myelosuppression

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15
Q

SEs docetaxel

A

Neutropenia

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16
Q

SEs irinotecan

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A

Myelosuppresion

17
Q

SEs cisplatin

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A

Nephrotoxicity
Ototoxicity
Peripheral neuropathy
Hypomagnesaemia

18
Q

SEs hydroxyurea

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A

Myelosuppresion

19
Q

Inheritance Li-Fraumeni syndrome

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A

Autosomal dominant

20
Q

Problem in Li-Fraumeni syndrome

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A

Germline mutations to p53 tumour suppressor gene → high incidence of malignancies, particularly sarcomas and leukaemias

21
Q

BRCA associations

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A

Breast cancer
Ovarian cancer
Prostate cancer (BRCA2)

22
Q

Inheritance Lynch syndrome

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A

Autosomal dominant

23
Q

Cancers in Lynch syndrome

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A

Colon
Endometrial

24
Q

Amsterdam criteria (high risk of Lynch syndrome)

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A

3+ family mebers with colorectal cancer (one 1st degree)
2 successive affected generations
1 or more colon cancers diagnosed under 50
FAP excluded

25
Inheritance Gardners syndrome
Autosomal dominant
26
Features Gardners syndrome
Multiple colonic polyps Skull osteoma Thyroid cancer Epidermoid cyst
27
Investigation suspected MSCC
Whole spine MRI within 24 hours
28
Treatment MSCC
High dose oral dex Urgent onc assessment for consideration of radiotherapy or surgery
29
CA125 marker for
Ovarian cancer
30
CA 19-9 marker for
Pancreatic cancer
31
CA 15-3 marker for
Breast cancer
32
AFP marker for
Hepatocellular carcinoma Teratoma
33
CEA marker for
Colorectal cancer
34
S-100 marker for
Melanoma Schwannomas
35
Bombesin marker for
SCLC Gastric cancer Neuroblastoma

1 - MSRA (23 decks)

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