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Flashcards in Cancer Deck (5)
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1
Q

what 3 changes occur in tumourgenesis

A

immortalisation: cells can divide indefinitely but obey contact inhibition
transformation: cells can divide indefinity but dont obey contact inhibition
metastasis

2
Q

describe c-myc oncogene function

A

produces a transcription factor which activates genes associated with cell division

3
Q

why must c-myc be carefully regulated

A

because if uncontrolled, then there’ll be unregulated activation of cell division genes leading to uncontrolled cell div, potentially cancer

4
Q

describe burkitt’s lymphoma

A

chromosome 8 has C-myc
chromosome 14 has enhancer for heavy chain of antibody
translocation occurs, so c-myc goes under enhancer on chromosome 14

ehancer causes constant expression of C myc, hence constant/uncontrolled division of B cell, hence B cell lymphoma

5
Q

how can burkitt’s lymphoma be detected

A

PCR:
J-trans-coding
put primer on D and coding
then separate by electrophoresis