Cancer Biologics Flashcards Preview

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Flashcards in Cancer Biologics Deck (11)
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1
Q

ATRA

A
  • for PML helps to differentiate cells

Tox: leukocytosis (N), capillary leak syndrome (pulmonary edema, respiratory failure, renal failure)

2
Q

Lenolidomide

A

unclear anti-inflammatory for MM

3
Q

Imatinib

A

tyrosine kinase inhibitor, binds cleft of ABL for CML tx; also for cKit inhibition in GIST
Tox: edema, rash, pancytopenia, GI
Resistance: cleft can mutate to escape

4
Q

Erlotinib

A

TKI in EGFR mutant NSCLC (women, non-smoker, with broncheoalveolar histology)
Tox: RASH, GI, Pulm

5
Q

Crizotinib

A
  • inhibits activin receptor-like kinase (ALK), ROS1 for NSCLC with EML4-ALK1 with kinase activity always, younger, non-smoker
6
Q

Vemurafenib

A

RAF Inhibitor, targets V600E BRAF

Tox: Skin cancers (cutaneous squamous cell and keratocanthomas)

7
Q

Bortezomib

A

Proteosome inhibitor for MM

Tox: neuropathy, myelosupression

8
Q

Rituximab

A

anti B-cell CD20 for B cell NHLs

Tox: HA, flushing, chills, fever, GI

9
Q

Cetuximab

A

MAB to EGFR, radiation sensitizer, K-RAS and BRAF WON’T RESPOND)

10
Q

Bevsacizumab

A

VEGF inhibitor
Tox: pulmonary hemorrhage in pt with squamous cell ca.
Tox: HTN, pulm hemorrhage, proteinuria

11
Q

Trastuzumab

A

blocks HER2 signalling, and cell mediated immunity

Tox: cardiac