Cancer Chemo Drug Subclasses

Question 1

What is the subclass of cyclophosphamide?

Answer 1

Alkylating agent

Question 2

What is the subclass of methotrexate?

Answer 2

Antimetabolite

Question 3

What is the subclass of vincristine?

Answer 3

Vinca alkaloids

Question 4

What is the subclass of etoposide?

Answer 4

Podophyllotoxins

Question 5

What is the subclass of 6-mercaptopurine?

Answer 5

Antimetabolite

Question 6

What is the subclass of Topotecan?

Answer 6

Camptothecins

Question 7

What is the subclass of Doxorubicin?

Answer 7

Anthracyclines

Question 8

What is the subclass of 5-Fluorouracil?

Answer 8

Antimetabolite

Question 9

What is the subclass of Paclitaxel?

Answer 9

Taxanes

Question 10

What is the subclass of imatinib?

Answer 10

Tyrosine kinase inhibitors

Question 11

What is the subclass of trastuzumab?

Answer 11

Growth factor receptor inhibitors

Question 12

What is the subclass of Bevacizumab?

Answer 12

Vascular endothelial growth factor (VEGF) inhibitor

Question 13

What is the subclass of bortezomib?

Answer 13

Proteasome inhibitor

Question 14

What is the MOA of cyclophosphamide?

Answer 14

Inhibits DNA synthesis and function by forming DNA cross-links. Alkylating agent.

Question 15

What are the clinical applications of cyclophosphamide?

Answer 15

Breast cancer, ovarian cancer, non-hodgkins lymphoma, chronic lymphocytic leukemia, and neuroblastoma

Question 16

What are the acute toxicities of cyclophosphamide?

Answer 16

Nausea and vomiting

Question 17

What are the chronic toxicities of cyclophosphamide?

Answer 17

Myelosuppression, alopecia, hemorrhagic cystitis

Question 18

What are some major alkylating agents?

Answer 18

mechlorethamine, procarbazine, carmustine, lomustine, dacarbazine, and cyclophosphamide

Question 19

What are the three platinum analogs?

Answer 19

ciplatin
carboplatin
oxaliplatin

Question 20

Which platinum analog causes gastrointestinal distress and mild hematotoxicity and is neurotoxic and nephrotoxic?

Answer 20

Ciplatin

Neurotoxicity is in the form of peripheral neuropathy and acoustic nerve damage.

Can reduce nephrotoxicity with mannitol and forced hydration.

Question 21

Which platinum analog is less nephrotoxic and neurotoxic, but is more likely to cause myelosuppression?

Answer 21

Carboplatin

Question 22

Which platinum analog has dose-limiting neurotoxicity?

Answer 22

Oxaliplatin

Question 23

MOA: which drug inhibits DHFR?

Answer 23

Methotrexate.

inhibits DHFR, which inhibits synthesis of thymidylate, purine nucleotides, serine, and methionine

Question 24

Which drug inhibits thymidylate synthase?

Answer 24

5-Fluorouracil

Question 25

Which drug inhibits de novo purine synthesis?

Answer 25

6-mercaptopurine

Question 26

Which drug's metabolites are incorporated into the RNA and DNA to inhibit DNA synthesis and RNA processing?

Answer 26

5-Fluorouracil

Question 27

What antimetabolite is used for acute myelogenous leukemia?

Answer 27

6-mercaptopurine

Question 28

Which antimetabolite is used for Gi cancers, breast cancer, neck and head cancer, and hepatocellular cancer?

Answer 28

5-fluorouracil

Question 29

Which antimetabolite is used for breast cancer, head and neck cancer, primary CNS lymphoma, non-Hodgkins lymphoma, bladder cancer and choriocarcinoma?

Answer 29

Methotrexate

Question 30

What drug has acute toxicities of mucositis and diarrhea, and chronic toxicities of myelosuppression?

Answer 30

Methotrexate

Question 31

What drug has acute toxicities of nausea and vomiting, and chronic toxicities of myelosuppression, immunosuppression, and hepatotoxicity?

Answer 31

6-mercaptopurine

Question 32

What drug has acute toxicities of nausea, mucositis, and diarrhea and chronic toxicities of myelosuppression and neurotoxicity?

Answer 32

5-fluorouracil

Question 33

What are some examples of antimetabolites?

Answer 33

cytarabine, gemcitabine, 5-fluorouracil, 6-mercaptopurine, and methotrexate

Question 34

What drug interferes with microtubule assembly, resulting in impaired mitosis?

Answer 34

Vincristine

Question 35

What drug inhibits topoisomerase II, resulting in DNA damage?

Answer 35

Etoposide

Question 36

Which drug inhibits topoisomerase I, resulting in DNA damage?

Answer 36

Topotecan

Question 37

Which drug is used for acute lymphocytic leukemia, Hodgkin's lymphoma, Non-hodgkin's lymphoma, Wilms' tumor, and neuroblastoma?

Answer 37

Vincristine

Question 38

Which drug is used for lung cancer, non-Hodgkin's lymphoma, and gastric cancer?

Answer 38

Etoposide

Question 39

What are the acute and chronic toxicities of vincristine?

Answer 39

No acute, but chronic include neurotoxicity with peripheral neuropathy, paralytic ileum, myelosuppression, alopecia, and inappropriate ADH secretion.

Question 40

What are the acute and long-term effects of etoposide?

Answer 40

Acute are nausea and vomiting, while alopecia and myelosuppression are longterm effects

Question 41

What are the acute and chronic toxicities of topotecan?

Answer 41

Acute are nausea, vomiting, and diarrhea, while myelosuppression is longterm.

Question 42

What drug interferes with the microtubule disassembly to impair mitosis?

Answer 42

Paclitaxel

Question 43

What drug's MOA includes oxygen free radicals binding to DNA to cause strand breakage, topoisomerase II inhibition, and is intercalated into DNA?

Answer 43

Doxorubicin

Question 44

Which drug inhibits the binding of EGF to the HER-2/neu growth receptor?

Answer 44

Trastuzumab

Question 45

Which drug inhibits the binding of VEGF to its receptor to inhibit the tumor vascularization?

Answer 45

Bevacizumab

Question 46

Which drug reversibly inhibits chymotrypsin-like activity of the 26S proteasome?

Answer 46

Bortezomib

Question 47

What are the clinical applications of Paclitaxel?

Answer 47

Breast, lung, ovarian, gastroesophageal, prostate, bladder, and head and neck cancer

Question 48

What are the clinical applications of Doxorubicin?

Answer 48

Lymphomas, myelomas, sarcomas, and breast, lung, ovarian and thyroid cancers

Question 49

What are the clinical applications of Imatinib?

Answer 49

Chronic myelogenous leukemia, GI stromal tumor

Question 50

What are the clinical applications of Trastuzumab?

Answer 50

HER-2/neu receptor-positive breast cancer

Question 51

What are the clinical applications of Bevacizumab?

Answer 51

Colorectal, breast, non-small cell lung and renal cancer

Question 52

What are the clinical applications of Bortezomib?

Answer 52

Multiple myeloma

Question 53

Which drug inhibits bar-abl tyrosine kinase and other receptor tyrosine kinases?

Answer 53

Imatinib

Question 54

What are the acute and longterm toxicities of Paclitaxel?

Answer 54

Acute toxicities include nausea, vomiting, hypotension, arrhythmias, and hypersensitivity, while longterm effects are myelosuppression and peripheral sensory neuropathy.

Question 55

What are the acute and longterm toxicities of Doxorubicin?

Answer 55

Nausea and arrhythmias are acute, while alopecia, myelosuppression, and cardiomyopathy are longterm.

Question 56

What are the acute and longterm toxicities of Trastuzumab?

Answer 56

Nausea, vomiting, chills, fever, and headache are acute, while cardiac dysfunction is longterm.

Question 57

What are the acute and longterm toxicities of Bevacizumab?

Answer 57

Hypertension and infusion reactions are acute, while arterial thromboembolic events, gastrointestinal perforation, wound healing complications, and proteinuria are longterm.

Question 58

What are the acute and longterm toxicities of Bortezomib?

Answer 58

Hypotension, edema, and GI upset are acute, while peripheral neuropathy and cardiac dysfunction are longterm.