Cancer chemotherapy Flashcards Preview

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Flashcards in Cancer chemotherapy Deck (11):
1

What are advantages to chemotherapy?

Eliminates micro-mestasteses

2

What are disadvantages of chemotherapy?

Lacks selective toxicity. It's cytotoxic to normal cells.

3

What is alopecia?

Hair falling out

4

Anti-cancer drugs kill cells according to what?

first order kinetics.

5

Reasons why giving chemo has lesser cell kill than theoretical?

- Toxicity: bone marrow suppression so treatment may have to be delayed for blood count to recover.

- Drug resistance: nearly always develps.

- Tumour growth characteristics: As tumor grows, cells are dormant and hard to kill.

6

What are CCS agents?

Cell cycle specific agents.
They act during a certain phase in the cycle. G0 seems to be unaffected

7

Examples of CCS agents?

Antimetabolites - methotrexate (Stop DNA synthesis)
Antimicrotubules - vinca alkaloids (induce metaphase arrest)
Podophyllin alkaloids - etopside (inhibit topoisomerase causing damage)

8

What are CCNS agents?

cell cycle non specific agents. Kill both dividing and G0 cells.

9

Examples of CCNS agents?

Alkylating agents
Anthracycline antibiotics
Platinum drugs
Hormonal agents

10

What are the 4 mechanisms of resistance?

1. Enhanced expression/alteration of target
2. Incr. production of glutathione (GSH) - inactivates drug and aids in elimination
3. Incr. repair capacity for DNA damage
4. Incr. expression of P-glycoprotein efflux pump (actively pumps out dru)

11

What is the best combination to over come resistance?

Use maximum tolerated does at the outset - initial aggressive therapy.