Cancer Diagnostics Flashcards

(39 cards)

1
Q

procedure that is performed to detect the presence of a specific disease in an asymptomatic person

A

screening (looks for the presence of cancer in population of healthy persons or asymptomatic)

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2
Q

process of identifying a disease based on its signs and symptoms, PE, and results of diagnostic/ancillary procedures

A

diagnosis, for the confirmation of a clinical suspicion of cancer

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3
Q

description of the extent of spread of the cancer

A

staging

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4
Q

monitoring the response to treatment/progress of disease/cancer recurrence

A

surveillance

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5
Q

t/f diagnostics isn’t important if patients choose to stop treatment or choose supportive care

A

false, still important to determine status of cancer

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6
Q

imaging modality that reduced mortality from breast cancer

A

mammography

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7
Q

most common requested radiographic imaging

A

cxr

- does not provide definitive diagnosis of lung ca at an early stage

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8
Q

t/f the presence of effusion can confirm cancer

A

false, both infection and cancer can cause effusion

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9
Q

purpose of ct scan

A
  • can be use to guide interventional procedures (biopsy, drainage, targeted rad)
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10
Q

screening test for lung cancer

A

low dose computed ct scan, reduction of 15-20% in lung ca mortality

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11
Q

indications for low dose computed ct scan

A
  • age 55-74
  • more/= 30 pack year smoking history
  • still smoking or have quit within the past 15 years
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12
Q

breast ca on mammogram can appear as __

A

masses, area of asymmetry, malignant calcifications, architectural distortions

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13
Q

birads category

A
0 incomplete
1 normal
2 benign
3 indeterminate
4 suspicious for malignancy
5 malignancy
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14
Q

mammogram screening recommendations

A

USPSTF: 40-49 yo individualized, 50-74 yo every 2 years
ACS: 40-44 yo annual, 45-54 annual
NCCN: more/= 40 yo annual

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15
Q

types of ultrasounds

A
  • breast
  • abdominal: liver, gb, spleen, pancreas, kidneys, urinary bladder, ascites
  • transvaginal/pelvic
  • endoscopic: esophageal, pancreatic, rectal
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16
Q

benign breast lesions on uts

A

simple cysts: circumscribed anechoic mass with thin imperceptible wall

complicated cysts: hypoechoic with no discernable doppler flow, internal echoes, indistinct margins

benign mass: oval or ellipsoid, wider than tall, circumscribed margins, smooth

17
Q

malignant breast lesions on uts

A

spiculatioins, angular margins, marked hypoechogenicity, post acoustic shadowing, microcalcificaitons, ductal ext, branching patterns, microlobulations

taller than wide and skin thickening

18
Q

principle of radionuclide imaging

A
  • application of radioactive substance taken internally -> external detectors capture and form images from the radiation emitted by the radiopharmaceuticals
19
Q

types of radionuclide imaging and pharmaceutical

A

bone: tc-99m with mdp
thyroid: i-131
ocreotide: iridium 111 pentetreotide
pet scan: flurodeoxyglucose

20
Q

t/f when a pet scan detects uptake of fdg tracer, it’s definite cancer

A

false, it might be cancer but not definite

21
Q

t/f in bone scan, more radioactive turnover = more radioactive material

22
Q

uses for fiberoptic bronchoscopy

A
  • evaluate centrally located tumors
  • assess the extent of airway obstruction
  • collect tissue sample for analysis
23
Q

uses for upper endoscopy (esophagogastroduodenoscopy)

A
  • investigate s/sx of gi
  • diagnose and biopsy
  • treatment for obstructions caused by tumors (stent for biliary tract or esophagus, clipping polyp)
  • screening test for high risk ugi neoplastic process
24
Q

uses of colonoscopy

A
  • screening test for crc in asymptomatic average risk individuals beginning age 50
  • endoscopic polypectomy: remove polyps via wire loop
25
uses for ercp
- pancreatobiliary disorders - both endoscopy and fluoroscopy of duodenum and ampulla of vater - therapeutic: stent insertion to relieve jaundice and pruritus
26
type of biopsy where tissue is obtained by application of suction through needle attached to syringe
aspiration biopsy
27
biopsy where inverted cone of tissue is excised as from the uterine cervix
cone biopsy
28
biopsy where removal of tissue through endoscope
endoscopic biopsy
29
tissue is removed by surgical cutting
excisional biopsy
30
circular blade is used and rotated through the epidermis and dermis and into subcutaneous fat
punch biopsy
31
biopsy of a skin lesion in which the sample is excised using a cut parallel to the surface of surrounding skin
shave biopsy
32
large hollow needle is used to extract a core of tissue
core needle biopsy (preferred when cancer is suspected because it removes more tissue than fnab and doesnt require surgery)
33
ihc stains and cancer equivalents
``` ttf1: lung cd-117: gi stromal tumor cytokeratin: epithelial origin lca (leukocyte common antigen): lymphoma estrogen receptor or progesterone receptor: breast ```
34
use of biomarkers or tumor markers
- treatment response | - not specific enough to permit a diagnosis of malignancy
35
targeted treatments for breast cancer
her2 neu: trstuzumab, pertuzumab, tdm-1, lapatinib | hormone: tamoxifen, aromatase inhibitors
36
targeted treatments for gastric ca
her2 neu: trastuzumab
37
targeted treatments for stage 4 colon ca
kras wild type: cetuximab and panitumumab
38
targeted treatments for gist
exon 9 and 11: imatinib and suntinib
39
targeted treatments for lung ca
egfr: tkis (geftitinib, erlotinib, afatinib, osimertinib) alk: crizotinib pdl1: immunotherapy (pembrolizumab, atezolizumab)