Cancer Drug study sheet Flashcards
(109 cards)
1
Q
5-FU class
A
pyrimidine analog
2
Q
Cytarabine class
A
cytosine analog
3
Q
6-MP class
A
purine analog
4
Q
methotrexate class
A
antifolate
5
Q
enzalutamide class
A
androgen receptor antagonist
6
Q
abiraterone class
A
a-hydrolyase inhibitor
7
Q
tamoxifen class
A
SERM
8
Q
fulvestrant class
A
ER antagonist
9
Q
letrozole class
A
non-steroidal aromatase inhibitor
10
Q
exemestane class
A
steroidal aromatase inhibitor
11
Q
leuprolide class
A
GnRH analogs
12
Q
A
13
Q
imatinib class
A
Type II kinase inhibitor of Abl-TK
14
Q
ponatinib class
A
Bcr-Abl inhibitor
15
Q
Midostaurin class
A
1st gen broad kinase inhibitor
16
Q
Quizartinib class
A
FLT3 kinsase inhibitor
17
Q
Crenolanib class
A
2nd gen specific kinase inhibitor of FLT3
18
Q
sirolimus class
A
rapalog
19
Q
dabrafenib class
A
BRAF v600 inhibitor
20
Q
Trametinib class
A
inhibits MEK1 and MEK2 for BRAF
21
Q
Acalabrutinib class
A
BTK inhibitor
22
Q
Gefitinib class
A
type 1 TKI
23
Q
Lapatinib class
A
TKI blocking HER2 and EGFR
24
Q
Afatinib class
A
covalent inhibitor of ErbB
25
Tucatinib class
TKI blocking HER2
26
Osimertinib class
covalent kinase inhibitor
27
chlorambucil class
alkylator
28
cyclophosphamide class
alkylator
29
mitomycin c class
alkylator
30
cisplatin class
platinum
31
irenotecan class
topo i inhibitor
32
doxorubicin class
topo ii inhibitor
intercalator
free radical damage
33
etoposide class
topo ii inhibitor (religation)
34
bleomycin class
intercolates and free radical damage
35
vincristine class
microtubule destabilizer
36
erubulin class
microtubule destabilizer
36
paclitaxel class
microtubule stabilizer
36
ixabepilone class
microtubule stabilizer
37
pembrolizumab class
human mab to PD-1 and block PD-L1
38
atezolizumab class
human mab to PD-L1 and block PD-1
39
ipilimumab class
human mab to CTLA-4
40
trastuzmab pertuzimab class
humanized mab
41
cetuximab class
chimeric mab
42
bevacizumab class
humanized mab
43
rituximab class
CD20 antibody
44
daratumumab class
CD38 antibody
45
olaparib class
PARP inhibitor
46
palbociclib class
CDK4/6 inhibitor
47
bortemzomib class
proteasome inhibitor
48
venetoclax class
BCL-2 inhibitor
49
pomalidomide class
degrades IKZF-TFs
50
TDM1 class
ADC
51
trastuzumab-deruxtecan class
ACD
52
blinatumomab class
Bite to CD3
53
mosunetuzumab class
bite to CD3 and CD20
54
teclistamab class
bite to CD3 on T cells
55
taquetamab class
bite to CD3 on t cells
56
when are antimetabolites/antifolates cell cycle specific
S phase during DNA replication
57
what is a dose limiting side effect of antimetabolites/antifolates
myelosuppression
58
how does leucovorate work with 5-FU
will increase efficacy of drug by increasing FH4 and therefore increase amount of complex to bind to thymidine synthase
59
what is the rescue drug for 5-FU
Thymidine
60
what is the resistant mechanism to 5-FU
down regulation of activating enzymes
upreg of thymidine synthase
deficiency of enzyme that breaks down 5-FU
61
how does tetrahydrouridine affect cytarabine
its a CDA inhibitor and will increase efficacy and decrease resistance of drug
62
resistance for cytarabine
down reg of activators
upreg of detoxers
down reg of transport into cells
63
what drug increases toxicity with 6-mp
allopurinol will increase toxicity
64
what should you test before 6-mp starts
loss of TMPT
65
what is the rescue drug for methotrexate
leucovorin
66
resistance to MTX
amplification of DHFR gene or mutation
decreased polyglutamation will pump out more of drug
67
resistance mechanism to enzalutamide
mutation in Androgen receptor
68
what is enzalutamide used for
prostate cancer
69
what is a negative effect of abiraterone
increased cholesterol
70
what is abiraterone used for
prostate cancer
71
tamoxifen genetic testing
ER+/PR+
72
who can use tamoxifen
pre and post menopausal breast cancer
73
fulvestrant genetics
ER+ breast cancer
74
who can use fulvestrant
post menopause
75
who can use letrozole
post menopause
76
who can use exemestane
ER+ breast cancer in post menopause
77
what is leuprolide used for
pre menopause BC and prostate cancer
78
what drugs require a gene test for Abl
imatinib and ponatinib
79
what drug targets the FTL3 gene
midostaurin
crenolanib
80
what drug targets ALK wild type
alectinib
81
what drug targets the ITD mutation
quizartinib
82
what KI drug targets BRAF mutations
dabrafenib
trametinib
83
what drug targets EGFR mutation
gefitinib
afatinib
osimertinib
84
what drug has resistance to T790M
gefitinib
85
what drug do you use with T790M mutation
osimertinib
86
what drug targets EGFR + HER2
Lapatinib
87
what KI is selective for HER2 mutation
tucatinib
88
what dose limitations do alkylators have
myelosuppression
89
what is a dose limiter for cisplatin
nephrotoxicity
90
what phase does cisplatin target
G1 more than S
91
how does glutathione affect cisplatin
decreases activity
92
what drug has to be given with cyclophosphamide
mesna (bladder toxicity)
93
what cell cycle does irenotecan target
s phase
94
what cell cycle does doxorubicin target
non cell cyclewhat
95
what cell cycle does etoposide target
G2 cell block
96
what does cell cycle does bleomycin target
G2 and M phase
97
what cell cycle does vincristine target
G2 and m phase
98
what cell cycle does paclitaxel target
M phase
99
what cell cycle does erubulin target
G2 and M phase
100
what cell cycle does ixabepilone target
M phase
101
dose limiting doxorubicin
cardiotoxicity and tissue damage
102
dose limiting bleomycin
pulmonary toxicity
103
dose limiting vincristine
neurotoxicity
104
dose limiting paclitaxel
myelosuppression
105
dose limiting erubuline
lower neurotoxicity
106
what is a resistant mechanism for all topo/microtubule drugs
PGP overexpression
107
what gene to test irenotecan
UGT1A1
