Cancer Drugs Flashcards by Payton Sterba

What does hydroxyurea treat?

granulocytic leukemia

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side effects of cisplatin?

nephrotoxicity

ototoxicity

peripheral neuropathy

electrolyte disturbances

nausea, vomiting

myelosuppression

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What does mercaptopurine treat?

acute leukemias

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side effects of trastuzumab?

cardiomyopathy

hypersensitivity

infusion reactions

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Risk of secondary malginancies?

Vincristine, vinblastine

Low risk

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What does carmustine treat?

brain tumors, multiple myeloma, melanoma

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Risk of secondary malginancies?

Methotrexate

Low risk

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choriocarcinoma, acute lymphocytic leukemia

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What does paclitaxel treat?

combination with cisplatin has become standard therapy for ovarian cancer

refractory ovarian cancer, breast cancer

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side effects of bleomycin?

pulmonary toxicity (unique, cumulative & potentially fatal)

minimal myelosuppression

skin vesiculation, hyperpigmentation

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What does vinblastine treat?

lymphomas

breast cancer

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side effects of leuprolide?

hot flashes

impotence

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Risk of secondary malginancies?

cytarabine

Low risk

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Risk of secondary malginancies?

paclitaxel

Unknown

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what does bleomycin treat?

germ cell tumors of testes and ovaries (probably the best for these)

head, neck, lung, lymphomas

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side effects of tamoxifen?

nausea, fatigue, bone & other musculoskeletal pain

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Risk of secondary malginancies?

mechlorethamine

High risk

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Risk of secondary malginancies?

etoposide

High risk

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side effects of doxorubicin?

cardiomyopathy

dexrazoxane can lessen cardiomyopathy by chelating Fe and preventing free radical damage

bone marrow depression

alopecia

GI problems

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what does prednisone treat?

lympholytic for lymphoma

lymphocytic for leukemia

breast cancer

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which drug is activated by CYP2D6?

tamoxifen

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which drugs lack significant bone marrow toxicity?

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vincristine, prednisone, belomycin

what does trastuzumab treat?

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25-30% of metastatic breast cancers that overexpress HER2

1st line Tx with paclitaxel

what does tamoxifen treat?

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advanced post-menopausal breast cancer

pre-menopausal metastatic breast cancer

break cancer prophylaxis for women at high risk

what does cisplatin treat?

testicular cancer cisplatin + paclitaxel = standard regimen for advanced ovarian cancer (wide spectrum) head, neck, bladder, small cell lung, colon, esophagus

which drug is not active without chelated Fe?

bleomycin

Risk of secondary malginancies? doxorubicin

Moderate risk

side effects of flutamide?

gynecomastia diarrhea hepatotoxicity (uncommon)

What is the major side effect difference between vinblastine and vincristine?

Vinblastine is strongly myelosuppressive

which drug promotes progenitors of neutrophils?

filgrastim

What does fluorouracil treat?

What does cytarabine treat?

acute leukemias very effective against acute myelocytic leukemia

palliative effects of prednisone?

anti-emetic, stimulates appetite, anti-inflammatory

what does procarbazine treat?

Hodgkin's lymphoma

Risk of secondary malginancies? bleomycin

Unknown

What does doxorubicin treat?

Wide spectrum, the most widely prescribed agent of this class _lymphomas, breast, ovary, small cell lung_ anti-angiogenic properties

What does methotrexate treat?

Risk of secondary malginancies? procarbazine

Moderate risk

side effects of paclitaxel?

myalgia/arthralgia dose-limiting leukopenia peripheral neuropathy

Risk of secondary malginancies? cyclophosphamide

Moderate risk

What does vincristine treat?

acute lymphocytic leukemia lymphomas Wilm's tumor neuroblastoma

interesting side effects of mercaptopurine?

jaundice, anorexia bone marrow depression, vomiting, nausea

Risk of secondary malginancies? cisplatin

Moderate risk

what does letrozole treat?

1st-line treatment of post-menopausal locally advanced or metastatic breast cancer

Risk of secondary malginancies? carmustine

High risk

What does cyclophosphamide treat?

a very broad spectrum of activity --- used against a wide variety of cancers

What does mechlorethamine treat?

combination therapy for Hodgkin's and non-Hodgkin's lymphoma

Risk of secondary malginancies? 5-fluorouracil

Low risk

what does leuprolide treat?

advanced hormonally responsive prostate cancer

what does etoposide treat?

lymphomas, acute leukemia, small cell lung, testis

broad spectrum of uses stomach, _colon_, pancreas, ovary, head and neck, _breast_, bladder basal cell carcinoma

side effects of filgrastim?

bone pain

what does flutamide treat?

metastatic prostate cancer used in combination with GnRH agonist

Cancer Drugs Flashcards

(53 cards)