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FPP MSS > Cancer Drugs > Flashcards

Cancer Drugs Flashcards

1
Q

What does hydroxyurea treat?

A

granulocytic leukemia

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1
Q

side effects of cisplatin?

A

nephrotoxicity

ototoxicity

peripheral neuropathy

electrolyte disturbances

nausea, vomiting

myelosuppression

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2
Q

What does mercaptopurine treat?

A

acute leukemias

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2
Q

side effects of trastuzumab?

A

cardiomyopathy

hypersensitivity

infusion reactions

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3
Q

Risk of secondary malginancies?

Vincristine, vinblastine

A

Low risk

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3
Q

What does carmustine treat?

A

brain tumors, multiple myeloma, melanoma

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4
Q

Risk of secondary malginancies?

Methotrexate

A

Low risk

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4
Q

choriocarcinoma, acute lymphocytic leukemia

A
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4
Q

What does paclitaxel treat?

A

combination with cisplatin has become standard therapy for ovarian cancer

refractory ovarian cancer, breast cancer

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5
Q

side effects of bleomycin?

A

pulmonary toxicity (unique, cumulative & potentially fatal)

minimal myelosuppression

skin vesiculation, hyperpigmentation

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6
Q

What does vinblastine treat?

A

lymphomas

breast cancer

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6
Q

side effects of leuprolide?

A

hot flashes

impotence

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8
Q

Risk of secondary malginancies?

cytarabine

A

Low risk

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8
Q

Risk of secondary malginancies?

paclitaxel

A

Unknown

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9
Q

what does bleomycin treat?

A

germ cell tumors of testes and ovaries (probably the best for these)

head, neck, lung, lymphomas

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9
Q

side effects of tamoxifen?

A

nausea, fatigue, bone & other musculoskeletal pain

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10
Q

Risk of secondary malginancies?

mechlorethamine

A

High risk

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12
Q

Risk of secondary malginancies?

etoposide

A

High risk

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12
Q

side effects of doxorubicin?

A

cardiomyopathy

dexrazoxane can lessen cardiomyopathy by chelating Fe and preventing free radical damage

bone marrow depression

alopecia

GI problems

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13
Q

what does prednisone treat?

A

lympholytic for lymphoma

lymphocytic for leukemia

breast cancer

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14
Q

which drug is activated by CYP2D6?

A

tamoxifen

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14
Q

which drugs lack significant bone marrow toxicity?

A

vincristine, prednisone, belomycin

15
Q

what does trastuzumab treat?

A

25-30% of metastatic breast cancers that overexpress HER2

1st line Tx with paclitaxel

16
Q

what does tamoxifen treat?

A

advanced post-menopausal breast cancer

pre-menopausal metastatic breast cancer

break cancer prophylaxis for women at high risk

17
Q

what does cisplatin treat?

A

testicular cancer

cisplatin + paclitaxel = standard regimen for advanced ovarian cancer

(wide spectrum) head, neck, bladder, small cell lung, colon, esophagus

18
Q

which drug is not active without chelated Fe?

A

bleomycin

19
Q

Risk of secondary malginancies?

doxorubicin

A

Moderate risk

20
Q

side effects of flutamide?

A

gynecomastia

diarrhea

hepatotoxicity (uncommon)

21
Q

What is the major side effect difference between vinblastine and vincristine?

A

Vinblastine is strongly myelosuppressive

23
Q

which drug promotes progenitors of neutrophils?

A

filgrastim

24
Q

What does fluorouracil treat?

A
26
Q

What does cytarabine treat?

A

acute leukemias

very effective against acute myelocytic leukemia

27
Q

palliative effects of prednisone?

A

anti-emetic, stimulates appetite, anti-inflammatory

29
Q

what does procarbazine treat?

A

Hodgkin’s lymphoma

32
Q

Risk of secondary malginancies?

bleomycin

A

Unknown

34
Q

What does doxorubicin treat?

A

Wide spectrum, the most widely prescribed agent of this class

lymphomas, breast, ovary, small cell lung

anti-angiogenic properties

35
Q

What does methotrexate treat?

A
37
Q

Risk of secondary malginancies?

procarbazine

A

Moderate risk

38
Q

side effects of paclitaxel?

A

myalgia/arthralgia

dose-limiting leukopenia

peripheral neuropathy

39
Q

Risk of secondary malginancies?

cyclophosphamide

A

Moderate risk

40
Q

What does vincristine treat?

A

acute lymphocytic leukemia

lymphomas

Wilm’s tumor

neuroblastoma

41
Q

interesting side effects of mercaptopurine?

A

jaundice, anorexia

bone marrow depression, vomiting, nausea

42
Q

Risk of secondary malginancies?

cisplatin

A

Moderate risk

42
Q

what does letrozole treat?

A

1st-line treatment of post-menopausal locally advanced or metastatic breast cancer

43
Q

Risk of secondary malginancies?

carmustine

A

High risk

44
Q

What does cyclophosphamide treat?

A

a very broad spectrum of activity — used against a wide variety of cancers

46
Q

What does mechlorethamine treat?

A

combination therapy for Hodgkin’s and non-Hodgkin’s lymphoma

47
Q

Risk of secondary malginancies?

5-fluorouracil

A

Low risk

49
Q

what does leuprolide treat?

A

advanced hormonally responsive prostate cancer

50
Q

what does etoposide treat?

A

lymphomas, acute leukemia, small cell lung, testis

51
Q

broad spectrum of uses

stomach, colon, pancreas, ovary, head and neck, breast, bladder

basal cell carcinoma

A
52
Q

side effects of filgrastim?

A

bone pain

53
Q

what does flutamide treat?

A

metastatic prostate cancer

used in combination with GnRH agonist

FPP MSS (2 decks)

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