cancer drugs Flashcards by Robert Perry

Q

methotrexate

A

folic acid derivative antimetabolite

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Q

leucovorin

A

folic acid derivative antimetabolite

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Q

pemetrexed

A

folic acid derivative antimetabolite

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Q

pralatraxate

A

folic acid derivative antimetabolite

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Q

5-Fluorouracil

A

pyrimidine analog antimetabolite

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Q

fluorodeoxyuridine

A

pyrimidine analog antimetabolite

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Q

cytarabine

A

pyrimidine analog antimetabolite

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Q

gemcitabine

A

pyrimidine analog antimetabolite

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Q

doxorubicin (adriamycin)

A

anthracycline ( DNA intercalators, antitumor antibiotics)

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Q

danunomycin (danuorubacin)

A

anthracycline ( DNA intercalators, antitumor antibiotics)

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Q

idamycin

A

anthracycline ( DNA intercalators, antitumor antibiotics)

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Q

mitoxantrone

A

anthracycline ( DNA intercalators, antitumor antibiotics)

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Q

dactinomycin

A

anthracycline ( DNA intercalators, antitumor antibiotics)

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Q

epirubicin

A

anthracycline ( DNA intercalators, antitumor antibiotics)

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Q

valrubicin

A

anthracycline ( DNA intercalators, antitumor antibiotics)

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Q

dexrazoxane

A

cytoprotective agent for doxorubicin SE: (enhances myelosupression of doxorubicin)

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Q

camptothecan

A

topoisomerase I inhibitor

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Q

topotecan

A

topoisomerase I inhibitor

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Q

irinotecan

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A

topoisomerase I inhibitor

Q

etoposide

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A

topoisomerase II inhibitor

Q

teniposide

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A

topoisomerase II inhibitor

Q

paclitaxel

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A

inhibits depolarization (anti-mitotic)

Q

docetaxel (taxotere)

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A

inhibits depolarization (anti-mitotic)

Q

ixabepilone (ixempra)

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A

inhibits depolarization (anti-mitotic)

vincristine (oncovin)

inhibits polymerization (anti-mitotic)

vinblastine (velban)

inhibits polymerization (anti-mitotic)

vinorelbine

inhibits polymerization (anti-mitotic)

vindesine

inhibits polymerization (anti-mitotic)

eribulin mesylate (halaven)

``` inhibits polymerization (anti-mitotic) metastatic breast cancer ```

maytansine

inhibits polymerization (anti-mitotic)

rhizoxin

inhibits polymerization (anti-mitotic)

Cabzitaxel (jevtana)

``` inhibits depolymerization (anti-mitotic) prostate cancer ```

imatinib (gleevec)

inhibitors of receptor tyrosine kinase | chronic myeloginos leukemia

ibrutinib (imbruvica)

inhibitor of burton's tyrosine kinase (B cell malignancies) Mantle cell lymphoma chronic lymphocytic leukemia

afatinib (gilotrif)

inhibits EGFR and HER2 tyrosine kinases | metastatic non-small cell lung cancer (NSCLC) with EGFR mutations

ceritinib ( zykadia)

inhibits ALK, IGF-1R, InsR (insulin receptor), and ROS1 tyrosine kinases alk + metastatic non-small cell lung cancer (NSCLC)

temsirolimus

inhibits mTOR a protein serine/threonine kinase and G1 growth arrest advanced renal cell carcinoma

everolimus

inhibits mTOR a protein serine/threonine kinase and G1 growth arrest advanced renal cell carcinoma

vemurafenib (zelboraf)

inhibits mutant B-Raf in malignant melanomas | mutant B-Raf + metastatic melanoma

trametinib (mekinist) (+) dabrafenib (tafinlar)

trametinib inhibits MEK, while dabrafenib inhibits B-Raf (V600E/K mutants) mutant B-Raf + metastatic melanoma

bortezomib (velcade)

inhibits 26s proteasome | multiple myeloma

carfilzomib (kyprolis)

inhibits 20s proteasome | multiple myeloma

vorinostat (zolinza) oral

histone deacetylase inhibitor | non-hodgkins t-cell lymphomas

romidepsin (istodax) IV

histone deacetylase inhibitor | non-hodgkins t-cell lymphomas

panobinostat (farydak) | combination with bortezomib and dexamethasone

histone deacetylase inhibitor | multiple myeloma

belinostat (beleodaq)

histone deacetylase inhibitor | relapsed and refractory peripheral t-cell lymphoma (PTCL)

IFL

irinotecan, 5-FU, and leucovorin | colorectal cancer