Cancer Drugs Flashcards
(94 cards)
1
Q
[Antimetabolite]
What is the MOA of 5-FU
A
inhibit thymidylate synthase
2
Q
Drug that cause hemorrhagic cystitis
A
Cyclophosphamide
3
Q
Drug the cause cardiomyopathy
A
Doxorubicin
4
Q
Chemo drugs that inhibit S-phase
A
CHEM 66 FU
Cytarabine Hydroxyurea Etoposide Methotrexate 6-mercaptopurine 6-thioguanine 5-FU
5
Q
Microtubule inhibitors
A
Vinblastine
Vincristine
Paclitaxel
6
Q
Regimen for HL
A
ABVD
7
Q
Regimen for NHL
A
CHOP
8
Q
FOLFIRI, FOLFOX regimen is used for
A
Colorectal CA
9
Q
Rescue agent for cisplatin
A
Amifostine
10
Q
Rescue agent for cisplatin
A
Amifostine
11
Q
[Cancer pain]
First line pain medication
A
Non-opioids
Aspirin, Paracetamol
12
Q
[Cancer pain]
pain persisting or increasing despite non-opioid use
A
- Opioid - Codeine
13
Q
[Cancer pain]
Pain persisting despite codeine
A
Add strong opioids such as morphine until the patient is free of pain
14
Q
[Cancer pain]
for children, how many steps in the ladder is recommended
A
2 steps only
15
Q
Drug that inhibits didydroorotate dehydrogenase in pyrimidine synthesis
A
Leflunomide
16
Q
Drug that inhibits thymidylate synthase
A
5-FU
17
Q
Drug that inhibits de novo purine synthesis
A
6MP
18
Q
Drugs that inhibit inosine monophosphate dehydrogenase
A
Mycophenolate and rivabirin
19
Q
Drug that inhibits ribonucleotide reductase
A
Hydroxyurea
20
Q
Drug that inhibit dihydrofolate reductase in humans
A
Methotrexate
21
Q
Drug that inhibit dihydrofolate reductase in bacteria
A
trimethoprim
22
Q
Drug that inhibit dihydrofolate reductase in protozoa
A
Pyrimethamine
23
Q
Drug that inhibits topoisomerase I
A
- Irinotecan
2. Topotecan
24
Q
Drug that inhibits topoisomerase II
A
- Etoposide
2. Teniposide
25
[Cancer Treatment modalities]
drug therapy is administered as the primary treatment
Primary Induction Therapy
26
[Cancer Treatment modalities]
use of chemotherapy in patients with localized cancer before performing local therapy
Neoadjuvant therapy
27
[Cancer Treatment modalities]
chemotherapy done after local treatment procedures to reduce the risk of local and systemic recurrence
Adjuvant chemotherapy
28
[Cancer Regimen]
ABVD
Hodgkin
29
[Cancer Regimen]
CHOP
Non-Hodgkin lymphoma
30
[Cancer Regimen]
GnRH agonist used for prostate CA
Leuprolide
31
[Cancer Regimen]
GnRH antagonist used to treat prostate CA
Abarelix
32
[Rescue Therapy]
Methotrexate
Leucovorin
33
[Rescue Therapy]
Cyclophosphamide
MESNA
34
[Rescue Therapy]
Doxorubicin
Dexrazoxane
35
[Rescue Therapy]
Cisplatin
Amifostine
36
[Alkylating agent]
Used for advanced colon and pancreatic cancer
Oxaliplatin
37
[Alkylating agent]
What are the side effects of cisplatin
1. Acoustic nerve damage
2. Peripheral neuritis
3. Nephrotoxicity
38
[Alkylating agent]
That has the highest carcinogenic potential
Procarbazine
39
Can cause pulmonary fibrosis
```
Bleomycin
Busulfan
Bromocriptine
Amiodarone
Nitrofurantoin
Methotrexate
```
40
[Alkylating agent]
Specific to CFU-GM line used as myelosuppressive agent prior to bone marrow transplant
Busulfan
41
What enzyme activates 6-mercaptopurine
HGPRT
42
What enzyme is inhibited by Fludrabine?
Ribonucleotide reductase
43
What enzyme is inhibited by Cladribine
Ribonucleotide reductase
44
[Antimetabolite]
used to treat mesothelioma; causes Hand-foot syndrome
Pemetrexed
45
[Antimetabolite]
What is the prodrug of 5FU?
Tegatur
46
[Antimetabolite]
Used for actinic keratoris and basal call CA?
Actinic keratorsis
47
[Antimetabolite]
used in CML in blast crisis
cytarabine
48
[Antimetabolite]
Most specific for the S phase of the cell cycle
Cytarabine
49
[Antimetabolite]
used for pancreatic CA
Gemtacibine
50
___ syndrome
a side effect of some chemotherapeutic drug characterized as redness, swelling, pain, blistering,
Hand-foot syndrome
51
[Vinca Alkaloid]
acts primarily in M phase of cell cycle
Vincristine
| Vinblastine
52
[Vinca Alkaloid]
causes peripheral neuritis
Vincristine
53
[Vinca Alkaloid]
Causes bone marrow suppression
VinBLASTine
54
Inhibits Topoisomerase II (DNA Gyrase)
Etoposide
| Teniposide
55
Inhibits topoisomerase I
Topotecan
| Irinotecan
56
[Campothecin]
used to treat metastatic colorectal CA
Irinotecan
57
What is the MOA of Taxanes (paclitaxel)
inhibits microtubule DISASSEMBLY
58
What is the MOA of vinca alkaloids?
Inhibits microtubule ASSEMBLY
59
What is the MOA of Doxorubicin?
1. Intercalates between base pairs
2. Inhibits topoisomerase II
3. generate free radicals
60
Type of cardiomyopathy due to Doxorubicin?
Dilated CMP
61
Antitumor antibiotics used in superficial bladder CA
Mitomycin
62
What antitumor antibiotic is most specific for the G2 phase of the cell cycle
Bleomycin
63
What is the oldest antitumor antibiotic?
Actinomycin/Dactinomycin
64
What oncogene that causes that CML acted upon by your tyrosine kinase inhibitors?
bcr-abl
65
What oncogene that causes GIST that is acted upon by your tyrosine kinase inhibitors?
c-kit
66
What Tyrosine Kinase is used for Idiopathic Pulmonary Fibrosis?
Nintedanib
67
MAB used for Her2/neu receptor positive breast CA
Trastuzumab
68
An antimetastatic breast CA drug that can cause congestive heart failure
trastuzumab
69
MAB that inhibits VEGF/VEGFR signaling
Bevacizumab
70
MAB that acts as multiple kinase inhibitor against VEGFR1 to 3 kinases used for thyroid CA
Lenvatinib
71
Monoclonal antibody used in low grade NHL; it induces complement-mediated lysis, direct cytotoxicity and induction of apoptosis
Rituximab
72
MAB that binds to EGFR and inhibits downstream EGFR signaling; enhances response to chemo and radiotherapy
Cetuximab
73
MAB used for colorectal CA
Cetuximab
74
An EGFR Tyrosine kinase inhibitor used for non-small cell lung CA and pancreatic cancer
Erlotinib
75
Interferon used for hairy cell leukemia, CML and T-cell lymphoma
Interferon alpha
76
Substrate-depleting enzyme used to treat acute lymphoblastic leukemia
Asparaginase
77
Allows DNA transcription and differentiation of immature leukemic promyelocytes into mature granulocytes
ATRA
Used in APML
78
What are the components of retinoic acid syndrome?
Dyspnea
Fever
Weight gain
peripheral edema
79
A selective estrogen receptor modulator used for hormone-sensitive breast CA; prevents osteoporosis and decreases risk of atherosclerosis
Tamoxifen
80
Androgen antagonist used for prostate C; competitive antagonist at androgen receptro
Flutamide
81
Androgen antagonist used for surgical castration
Nilutamine
82
What is administered with flutamide to prevent acute flare up of prostate cancer
Leuprolide
83
An estrogen synthesis inhibitor that inhibits aromatase
Anastrazole, Letrozole
84
Hormonal anticancer drug that is used in precocious puberty
Anastrazole
| Letrozole
85
Hormonal anticancer drug that is effective against breast cancers that have become resistant to tamoxifen
Anastrazole
| Letrozole
86
Alkylating agent used for brain tumors such as astrocytoma and glioblastoma multiforme
Temozolomide
87
Mitotic inhibitor used for metastatic breast Cancer
Eribulin
88
What is the MOA of hydroxyurea?
Inhibit ribonucleotide reductase
89
MAB that targets CD30 cells used for hodgkin lymphoma
Brentuximab
90
What anticancer drug is used as an immunosuppressant in organ transplantation and advanced kidney CA
Everolimus
Sirolimus
These are mTOR inhibitor
91
A humanized anti-CD20 MAB used for chronic CLL and follicular lymphoma
Obinutuzumab
92
IgG4 isotype antibody that blocks protective mechanism of CA cells allowing immune system to destroy CA cells
Pembrolizumab
93
An EGFR-TK inhibitor used for advances non small cell lung CA
Osimertinib
94
First therapeutic proteasome inhibitor used for multiple myeloma and mantle cell lymphoma
Bortezomib
