Cancer Drugs Basics (Drugs-Classes)

Question 1

What are the 7 classes of cancer drugs?

Answer 1

Alkylating agents
Antimetabolites
DNA intercalators
Microtubule inhibitors
Topoisomerase inhibitors
Hormones and their inhbitors
Misc.

Question 2

What are 4 subclasses of alkylating agents

Answer 2

Nitrogen Mustards
Nitrosureas
Triazenes
Platinum Analogues

Question 3

What are 3 subclasses of Antimetabolites

Answer 3

Folate analogs
Pyrimidine Analogs
Purine analogs

Question 4

What are 3 subclasses of DNA intercalators (2 are just straight up drugs the other is a subclass that includes a few)

Answer 4

Bleomycin
Dactinomycin
Anthracyclines

Question 5

What are 2 subclasses of Microtubule Inhibitors?

Answer 5

Vinca Alkyloids

Taxanes

Question 6

What are 2 subclasses of Topoisomerase inhbitors?

Answer 6

Epipodophyllotoxins

Camptothecin Analogs

Question 7

What are 6 subclasses of Hormones related drugs?

Answer 7

Gluccocorticoids
Non Steroidal Androgen Receptor inhibitors
GnRH analogs
SERMs
SERDs
Aromatase Inhibitors

Question 8

Name 3 Nitrogen Mustards

Answer 8

Mechlorethamine (Mustargen)
Cyclophosphamide (cytoxan)
Ifosfamide (Ifex)

Question 9

Name 2 nitrosureas

Answer 9

Carmustine (Gliadel)

Lomustine (Ceenu)

Question 10

Name 3 triazenes

Answer 10

Dacarbazine (DTIC)
Procarbazine (Matulane)
Temozolmide (Temodar)

Question 11

Name 3 platinum analogs

Answer 11

Cisplatin (platinol)
Carboplatin (Paraplatin)
Oxaliplatin (Eloxatin)

Question 12

Name 2 Folate Analogs

Answer 12

Methotrexate (trexall) DHFR inhbitor

Pemetrexed (alimta)

Question 13

Name 3 pyrimidine analog

Answer 13

5-Fuorouracil (5-FU, Carac)
Cytarabine (AraC, Depocyt)
Gemcitabine (dFdC, Gemzar)

Question 14

Name 1 purine Analogs

Answer 14

6-Mercaptopurine (purinethol)

Question 15

Name 4 anthracyclines

Answer 15

Daunorubicin (Cerubidine)
Idarubicin (Idamycin)
Doxorubicin (Adriamicin, doxil)
Epirubicin (ellence)

Question 16

Name 2 Vinca Alkaloids

Answer 16

Vinblastine (velban)

Vincristine (oncovin)

Question 17

Name 2 taxanes

Answer 17

Paclitaxel (taxol, abraxane)

Docetaxol (taxotere)

Question 18

Name 2 epipodophyllotoxins (topo II)

Answer 18

Etoposide (Etopophos)

Teniposide (Vumon)

Question 19

Name 2 Capthothecin Analogs

Topo I

Answer 19

Irinotecan (Camptosar)

Topotecan (Hycamtin)

Question 20

Name 2 glucocorticoids

Answer 20

Prednisone (Meticorten)

Dexamethasone (Decadron)

Question 21

Name a SERM

Answer 21

Tamoxifen (Soltamox)

Question 22

Name a SERD

Answer 22

Fluvestrant (Faslodex)

Question 23

Name 4 aromatase inhibitors

Answer 23

Aminoglutethamide (Cytadren)
Anastrozole (arimidex)
Letrozole (Femara)
Exemestane (Aromasin)

Question 24

Name 2 GnRH analogs

Answer 24

Leuprolide (Lupron)

Goserelin (Zoladex)

Question 25

Name 2 Non Steroidal Androgen Receptor Blockers

Answer 25

Flutamide (eulexin) | Bicalutamide (casodex)

Question 26

Verapamil

Answer 26

Ca2+ channel blocker inhibits pumps such as P-GP from excreting drug from cell

Question 27

Leucovorin

Answer 27

FH4 analog used to recue healthy cells after treatment with methotrexate.

Question 28

Dexrazoxane

Answer 28

Drug used to help reduce cardiotoxicity associated with anthracyclines

Question 29

Filgrastin and Nulasta

Answer 29

Granulocyte colony stimulating factor, helps fight neutropenia.