Cancer genes Flashcards
(27 cards)
BCR-ABL
oncogene/tyrosine kinase
CML
ALL
BCL-2
oncogene/anti-apoptotic
follicular lymphoma
undifferentiated lymphoma
BRAF
oncogene/serine-threonine kinase
melanoma
non-Hodgkin lymphoma
c-kit
oncomgene/cytokine receptor
gastrointestinal stromal tumour
GIST
c-myc
oncogene/transcription factor
burkitt lymphoma
Her2/neu
c-erbB2
oncogene/tyrosine kinase
breast
ovarian
gastric carcinomas
L-myc
oncogene/transcription factor
lung tumour
N-myc
oncogene/transcription factor
neuroblastoma
RAS
oncogene/GTPase
colon cancer
lung cancer
pancreatic cancer
RET
oncogene/tyrosine kinase
MEN2A
MEN2B
medullary thyroid cancer
oncogene
gain of function mutation increases risk of cancer
only need ONE allele to cause cancer
tumour suppressor gene
loss of function mutation increases risk of cancer
need TWO alleles to cause cancer
‘‘two hit hypo’’ when Dr Sobering visited Newcastle MEMO CUE
APC
tumour suppressor
colorectal cancer - FAP
BRCA1/BRCA2
tumour suppressor/DNA repair protein
DCC
tumour suppressor
colon cancer
deleted in colon cancer
DPC4/SMAD4
tumour suppressor
pancreatic cancer
deleted in pancreatic cancer
MEN1
tumour suppressor/menin
Men1
NF1
tumour suppressor/Ras GTPase (like colon cancer, lung cancer and pancreatic cancer when an oncogene)
neurofibromatous 1
NF2
tumour suppressor/merlin - schwannomin protein
p16
tumour suppressor/cyclin-depedent kinase inhibitor 2A
melanoma
p53
tumour suppressor/transcription factor for p21; blocks g1-s
Li fraumeni
most human cancers
PTEN
tumour suppressor/
breast cancer
prostate cancer
endometrial cancer
Rb
tumour suppressor/inhibits E2F; blocks G1-S phase
TSC1
tumour suppressor/hamartin protein
Tuberous sclerosis
