Cancer IV Flashcards Preview

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Flashcards in Cancer IV Deck (18)
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1
Q

What are ScFv antibodies?

A

Displayed on bacteriophage and are usually derived from DNA libraries that people have produced

2
Q

What is Rituximab used for?

A

Non-lymph Hodgkin lymphoma

3
Q

What is Bevacizumab used for?

A

Colon cancer alongside chemotherapy + given with 5-FU, IV

4
Q

What is cetuximab used for?

A

Colon cancer and head and neck cancer

5
Q

What is herceptin used for?

A

Breast cancer - binds to extracellular domain of Her-2

6
Q

How is perception administered?

A

IV

7
Q

What are the adverse side effects of herceptin?

A

Heart failure

8
Q

How does bevacizumab work?

A

Stops new blood vessels from forming by binding to vascular endothelial growth factor

9
Q

What does Rituximab bind to?

A

CD20, in B cells (only expressed in B-cell non-hodgkin lymphoma)

10
Q

What does Cetuximab target?

A

EGF receptor - may interfere with cancer cell growth by preventing EGF binding

11
Q

What is cetuximb given with and how?

A

IV with irinotecan

12
Q

What does L-asaparaginase target?

A

Features of leukaemia cells - starve them of metabolic components. Cancer cells cannot make asparagine from aspartate and so relies on the uptake from the blood

13
Q

What do interferons do?

A

Anti cancer effects and stimulate the immune system to reject the cancer - not well tolerate at high doses

14
Q

What are the two major types of interferons?

A

Type I (alpha and beta) and type II (gamma)

15
Q

Where are type I produced from?

A

Fibroblast cells

16
Q

Where are type II produced from?

A

T cells and particular immune cells

17
Q

What do interferons do?

A

Promote apoptosis

18
Q

What is interleukin 2?

A

T-lymphocyte growth factor