Cancer markers and autoantibodies

Question 1

CA 125

Answer 1

Ovarian cancer

Question 2

CA 19-9

Answer 2

Pancreatic cancer

Question 3

CA 15-3

Answer 3

Breast cancer

Question 4

PSA

Answer 4

Prostatic carcinoma

Question 5

Alpha-feto protein (AFP)

Answer 5

Hepatocellular carcinoma, teratoma

Question 6

S-100

Answer 6

Melanoma and schwannomas

Question 7

Bombesin

Answer 7

Small cell lung carcinoma, gastric cancer, neuroblastoma

Question 8

Ovarian cancer

Answer 8

CA 125

Question 9

Pancreatic cancer

Answer 9

CA 19-9

Question 10

Breast cancer

Answer 10

CA 15-3

Question 11

Prostatic carcinoma

Answer 11

PSA

Question 12

Hepatocellular carcinoma, teratoma

Answer 12

Alpha-feto protein (AFP)

Question 13

Melanoma and schwannomas

Answer 13

S-100

Question 14

Small cell lung carcinoma, gastric cancer, neuroblastoma

Answer 14

Bombesin

Question 15

Carcinoembryonic antigen (CEA)

Answer 15

Colorectal cancer

Question 16

Colorectal cancer

Answer 16

Carcinoembryonic antigen (CEA)

Question 17

ACL

Answer 17

Antiphospholipid syndrome

Question 18

Ferritin

Answer 18

Adult onset still’s disease

Question 19

pANCA

Answer 19

Churg-straus angitis, microscopic polyangitis

Question 20

cANCA

Answer 20

Wegener’s granulomatosis

Question 21

Topoimerase/Scl-70

Answer 21

Diffuse sceleroderma (especially lung disease)

Question 22

Centromere

Answer 22

Limited cutaneous scleroderma

Question 23

RNP (ribonuclear protein)

Answer 23

Mixed connective tissue disease

Question 24

Antiphospholipid syndrome

Answer 24

ACL

Question 25

Adult onset still's disease

Answer 25

Ferritin

Question 26

Churg-straus angitis, microscopic polyangitis

Answer 26

pANCA

Question 27

Wegener's granulomatosis

Answer 27

cANCA

Question 28

Diffuse sceleroderma (especially lung disease)

Answer 28

Topoimerase/Scl-70

Question 29

Limited cutaneous scleroderma

Answer 29

Centromere

Question 30

Mixed connective tissue disease

Answer 30

RNP (ribonuclear protein)

Question 31

Smith (Sm)

Answer 31

SLE (low sensitivity highly specific)

Question 32

La

Answer 32

SLE, Sjogrens

Question 33

Ro

Answer 33

SLE, Sjogrens (causes neonatal heart block)

Question 34

Ds DNA

Answer 34

80% SLE

Question 35

Antinuclear antibody

Answer 35

99.9% SLE

Question 36

Rheumatoid factor/ACPA

Answer 36

RA (RF present in Sjogrens)

Question 37

SLE (low sensitivity highly specific)

Answer 37

Smith (Sm)

Question 38

SLE, Sjogrens

Answer 38

La

Question 39

SLE, Sjogrens (causes neonatal heart block)

Answer 39

Ro

Question 40

80% SLE

Answer 40

Ds DNA

Question 41

99.9% SLE

Answer 41

Antinuclear antibody

Question 42

RA (RF present in Sjogrens)

Answer 42

Rheumatoid factor/ACPA

Question 43

anti-mitochondrial antibodies (AMA) M2 subtype smooth muscle antibodies (in 30%) and raised serum IgM

Answer 43

Primary biliary cholangitis (previously primary biliary sclerosis)

Question 44

Previous history of UC, ANCA

Answer 44

Primary sclerosing cholangitis

Question 45

Lactate dehydrogenase (LDH)

Answer 45

Testicular cancer

Question 46

Primary sclerosing cholangitis

Answer 46

ANA and ANCA

Question 47

Anti-GBM

Answer 47

Goodpastures

Question 48

Polymyositis and Dermatomyositis

Answer 48

Jo 1, Mi 2 and ANA

Question 49

Primary biliary cholangitis (previously primary biliary sclerosis)

Answer 49

anti-mitochondrial antibodies (AMA) M2 subtype smooth muscle antibodies (in 30%) and raised serum IgM

Question 50

Primary sclerosing cholangitis

Answer 50

Previous history of UC, ANCA

Question 51

Testicular cancer

Answer 51

Lactate dehydrogenase (LDH)

Question 52

ANA and ANCA

Answer 52

Primary sclerosing cholangitis

Question 53

Goodpastures

Answer 53

Anti-GBM

Question 54

Jo 1, Mi 2 and ANA

Answer 54

Polymyositis and Dermatomyositis