Cancer Pharmacology (Kruse)

Question 1

How is mercaptopurine activated

Answer 1

Inactive in parent form

Metabolized by HGPRT

Question 2

What antibodies did we cover in lectures

Answer 2

Bevacizumab & Ziv-aflibercept

Question 3

What antimetabolite purine analog did we discuss in class

Answer 3

Mercaptopurine (6-MP)

Question 4

What antitumor antibiotic causes single and double stranded DNA breaks

Answer 4

Bleomycin

Question 5

What antitumor antibiotic inhibits topoisomerase 2 and intercalates DNA

Answer 5

Doxorubicin

Question 6

What are the common M Phase cell cycle inhibitors we discuses in class and what are their drug classes

Answer 6

Natural Antineoplastic Agents

Bleomycin - Antitumor antibiotic

Paclitaxel & Docetaxel - Taxane

Vinblastine & Vincristine - Vinca Alkaloids

Question 7

What are the side effects of Bleomycin

Answer 7

Pulmonary toxicities

Question 8

What are the side effects of Vinblastine

Answer 8

Alopecia

Bone marrow supression

Myelosuppression to a great extent than vincristine

Question 9

What are the side effects of Vincristine

Answer 9

Alopecia

Bone marrow supression

Cumulative neurologic toxicities to a greater extent than vinblastine

Question 10

What drug binds to beta tubulin and inhibits microtubule assembly (depolarization)

Answer 10

Vinblastine & Vincristine

Question 11

What drug category is carmustine

Answer 11

Nitrosourea - Alkylating agent

Question 12

What drug class are Vinblastine & Vincristine

Answer 12

Vinca Alkaloids

Question 13

What drug class in Ziv-aflibercept

Answer 13

Tyrosine Kinase growth factor receptor inhibitor

Question 14

What drug class is Doxorubicin

Answer 14

Anthracycline

Question 15

What drug inhibits the BCR-ABL fusion protein & what is it’s MOA

Answer 15

Imatnib

Inhibits the ABL tyrosine kinase

Question 16

What drug is a calcium channel blocker that inhibits P-glycoprotein transporters

Answer 16

Verapamil

Question 17

What drug is used as an implantable wafer in the brain to treat malignant glioma as an adjunct to surgery and radiation

Answer 17

Carmustine

Question 18

What drug reduces the toxic side effects of methotrexate

Answer 18

Leucovorin

Question 19

What drugs are associated withe the p-glycoprotein resistance mechanism & what are their MOA

Answer 19

Vinca alkaloids

Etoposide & anthracyclines - Inhibit topoisomerase 2

Paclitaxel

Dactinomycin - intercalates DNA

Question 20

What drugs bind to beta tubulin and stabilize microtubule formation

Answer 20

Paclitaxel, Docetaxel & Cabazitaxel

Question 21

What enzyme metabolizes mercaptopurine to the inactive metabolite

Answer 21

Xanthine oxidase (first pass)

Question 22

What is the adverse side effect of Doxorubicin

Answer 22

Cardiovascular toxicity from production of free radicals

Question 23

What is the drug class of Paclitxael, Docetaxel & Cabazitaxel

Answer 23

Taxanes

Question 24

What is the MOA of Bevacizumab

Answer 24

Monoclonal antibody that binds to VEGF-A preventing ligands from binding to it

Question 25

What is the MOA of ziv-aflibercept

Answer 25

Binds VEGF-A, VEGF-B and prevents them from binding to VEGF receptor Also binds PIGF

Question 26

What is the side effect of Docetaxel

Answer 26

Hypersensitivity, neutropenia and hair loss

Question 27

What is the side effect of Paclitaxel

Answer 27

Hypersensitivity reactions in hands and toes Change in taste

Question 28

What taxane avoids the mechanism of resistance of P-glycoprotein

Answer 28

Cabazitaxel

Question 29

Which taxane has a greater cellular uptake and is retained intracellularly longer, leading to smaller dose and less side effects

Answer 29

Docetaxel