cancer points to learn Flashcards

1
Q

what is the highest grade of squamous dysplasia?

A

carcinoma in situ - benign

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2
Q

spiculation

A

a lump of tissue with spikes or points on the surface

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3
Q

tripclar mitosis

A

malignant

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4
Q

lintis plastica

A

when the stomach has thickened walls due to diffuse infiltration by cancer cells

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5
Q

what cancer does salt cause

A

gastric

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6
Q

what do calcium supplemnets do

A

increase chance of prostate cancer and decrease chance of colorectal cancer

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7
Q

who shoudl take folic acid

A

pregnant women

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8
Q

when is red wine protective

A

post menopausal - 1 a day

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9
Q

what cancers does coffee reduce the risk of

A

liver and endometrial

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10
Q

what is neureoectodermal cancer

A

cancer of malenocytes and glial cells of the CNS

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11
Q

where does lung cancer met to

A

bone, brain, adrenal and liver

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12
Q

where do sarcomas invade

A

locally - rather than via blood eg carcinoma

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13
Q

what happens to your FBC in haematological malignancies?

A

increase as malignant cells replace everyhting

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14
Q

what does a lymphoma look like

A

solid white mass - cells look like their origin as oppose to their met

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15
Q

does primary brain cancer met

A

no because of the BBB

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16
Q

what does PSA mark

A

prostate cancer - used for diagnosis and monitoring

17
Q

what is the normal reference range for PSA

18
Q

what is used to monitor therapy in testicular cancer

19
Q

what causes new bone formation

A

osteoblasts - they prododuce new ALP (Also found in biliary tree of liver)

20
Q

how do you investigate bone mets

A

isotope bone scan

21
Q

what is an adjuvant

A

after surgery - reduces risk of recurrance

22
Q

what is a neo-adjuvant

A

before surgery to shrink tumour

23
Q

what is tranzutumab

A

monoclonal antibody of HER2 and EGFR family

24
Q

what is the definitoin of cancer

A

somatic mosaicism largely caused by post-zygomatic mutations

25
which genes reair DNA strand breaks
BRACA1, BRACA2, RAD51
26
what is xeroderma pigmentation
single stranded DNA repair malfunction
27
what cancer is HNPCC lynch syndrome realted to
colorectal + endometrial
28
driver mutation
mutations that drive carcinongenesis
29
passenger mutations
incidental mutation that happens because the tumour is unstable
30
what is BRAF associated with
melanoma
31
what is MLH1 associated with
bowel cancer
32
what is the inheritance pattern of breast cancer
autosomal dominant
33
what is the hormonal manipulation drug used for breast cancer
tamoxifen