Cancer Syndrome Criteria Flashcards Preview

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Flashcards in Cancer Syndrome Criteria Deck (80):
1

- Spotty skin pigmentation on lips, conjunctiva and inner or outer canthi, and/or vaginal or penila mucosa

Carney Complex criteria

2

- Large cell calcifying Sertoli cell tumor or characterstic calcification on testicular U/S

Carney Complex criteria

3

- Myxoma (cutaneous and mucosal)

Carney Complex criteria

4

- Cardiac myxoma

Carney Complex criteria

5

- Breast myxomatosis or fat-suppressed MRI findings suggestive of this dx

Carney Complex criteria

6

- Acromegaly due to growth hormone-producing adenoma

Carney Complex criteria

7

- Primary pigmented nodular adrenocortical dysplasia

Carney Complex criteria

8

Thyroid carcinoma (nonmedullary) or multiple hypoechoic nodules on thyroid U/S in a young patient

Carney Complex criteria

9

Psammomatous melanotic schwannoma

Carney Complex criteria

10

Blue nevus, epithelioid blue nevus (multiple)

Carney Complex criteria

11

Breast ductal adenoma (multiple)

Carney Complex criteria

12

Osteochondromyxoma

Carney Complex criteria

13

Breast cancer is a major criteria piece for _________

Cowden Syndrome Major Criteria

14

Endometrial cancer (epithelial)

Cowden Syndrome Major Criteria

15

Follicular Thyroid Cancer

Cowden Syndrome Major Criteria

16

GI hamartomas (including ganglioneuromas but excluding hyperplastic polyps; 3 or more)

Cowden Syndrome Major Criteria

17

Lhermitte-Duclos disease (adult)

Cowden Syndrome Major Criteria

18

Macrocephaly (58 cm for women, 60 cm for men; 97th+ percentile)

Cowden Syndrome Major Criteria

19

Macular pigmentation of the glans penis

Cowden Syndrome Major Criteria

20

Multiple mucocutaneous lesions (any of the following): - multiple trichilemmomas (3+, at least 1 proven by biopsy) - Acral keratoses (3+ palmoplantar keratotic pits and/or acral hyperkeratotic papules) - Mucocutaneous neuromas (3+) - Oral papillomas (particularly on tongue and gingival), multiple (3+) OR biopsy proven OR dermatologist diagnosed

Cowden Syndrome Major Criteria

21

Autism spectrum disorder

Cowden Syndrome Minor Criteria

22

Colon cancer

Cowden Syndrome Minor Criteria

23

Esophageal glycogenic acanthosis (3+)

Cowden Syndrome Minor Criteria

24

Lipomas (3+)

Cowden Syndrome Minor Criteria

25

Intellectual disability (ie. IQ

Cowden Syndrome Minor Criteria

26

Renal cell carcinoma

Cowden Syndrome Minor Criteria

27

Testicular lipomatosis

Cowden Syndrome Minor Criteria

28

Thyroid cancer (papillary or follicular variant of papillary)

Cowden Syndrome Minor Criteria

29

Thyroid structural lesions (e.g. adenoma, multinodular goiter)

Cowden Syndrome Minor Criteria

30

Vascular anomalies (including multiple intracranial developmental

Cowden Syndrome Minor Criteria

31

Soft-tissue sarcoma

Li-Fraumeni Syndrome associated tumor

32

Osteosarcoma

Li-Fraumeni Syndrome associated tumor

33

Brain tumor

Li-Fraumeni Syndrome associated tumor

34

Breast cancer (often before 35)

Li-Fraumeni Syndrome associated tumor

35

Adrenocortical tumor

Li-Fraumeni Syndrome associated tumor

36

Leukemia

Li-Fraumeni Syndrome associated tumor

37

Bronchoalveolar cancer (type of lung cancer)

Li-Fraumeni Syndrome associated tumor

38

Colorectal cancer

Li-Fraumeni Syndrome associated tumor

39

Colorectal adenocarcinoma

Lynch Syndrome associated tumor

40

Endometrial adenocarcinoma

Lynch Syndrome associated tumor

41

Urothelial carcinoma (ureter and renal collecting ducts)

Lynch Syndrome associated tumor

42

Gastric cancer

Lynch Syndrome associated tumor

43

Ovarian

Lynch Syndrome associated tumor

44

Small bowel cancer

Lynch Syndrome associated tumor

45

Glioblastoma

Lynch Syndrome associated tumor

46

Sebaceous Adenocarcnioma

Lynch Syndrome associated tumor

47

Biliary tract cancer

Lynch Syndrome associated tumor

48

Pancreatic cancer

Lynch Syndrome associated tumor

49

Lamellar calcification of the falx in an individual younger than age 20

Nevoid basal cell carcinoma syndrome (Gorlin Syndrome) major criteria

50

Jaw keratocyst

Nevoid basal cell carcinoma syndrome (Gorlin Syndrome) major criteria

51

Palmar or Plantar pits

Nevoid basal cell carcinoma syndrome (Gorlin Syndrome) major criteria

52

Multiple basal cell carinomas (>5 in a lifetime) or a basal cell carcinoma dx before age 30 (excluding BCC that develop after radiotherapy)

Nevoid basal cell carcinoma syndrome (Gorlin Syndrome) major criteria

53

Childhood medulloblastoma (primitive neuroectodermal tumor)

Nevoid basal cell carcinoma syndrome (Gorlin Syndrome) minor criteria

54

Lymphomesenteric or pleural cysts

Nevoid basal cell carcinoma syndrome (Gorlin Syndrome) minor criteria

55

Macrocephaly (occipital frontal circumference >97th percentile)

Nevoid basal cell carcinoma syndrome (Gorlin Syndrome) minor criteria

56

Cleft lip or cleft palate

Nevoid basal cell carcinoma syndrome (Gorlin Syndrome) minor criteria

57

Vertebral or rib anomalies observed on X-ray

Nevoid basal cell carcinoma syndrome (Gorlin Syndrome) minor criteria

58

Preaxial or post axial polydactyly

Nevoid basal cell carcinoma syndrome (Gorlin Syndrome) minor criteria

59

Ovarian or cardiac fibromas

Nevoid basal cell carcinoma syndrome (Gorlin Syndrome) minor criteria

60

Ocular anomalies (cataract, developmental defects, and pigmentary changes of the retinal epithelium)

Nevoid basal cell carcinoma syndrome (Gorlin Syndrome) minor criteria

61

Facial angiofibromas or forehead plaque

Tuberous sclerosis complex major criteria

62

Nontraumatic ungual or periungual fibroma

Tuberous sclerosis complex major criteria

63

Hypomelanotic macules (3+)

Tuberous sclerosis complex major criteria

64

Shagreen patch (connective tissue nevus)

Tuberous sclerosis complex major criteria

65

Cortical tuber in the brain

Tuberous sclerosis complex major criteria

66

Subependymal glial nodule

Tuberous sclerosis complex major criteria

67

Subependymal giant cell astrocytoma

Tuberous sclerosis complex major criteria

68

Multiple retinal nodular hamartomas

Tuberous sclerosis complex major criteria

69

Cardiac rhabdomyomas, single or multiple

Tuberous sclerosis complex major criteria

70

Lymphangiomyomatosis

Tuberous sclerosis complex major criteria

71

Renal angiomyolipoma

Tuberous sclerosis complex major criteria

72

Multiple, randomly distributed pits in dental enamel

Tuberous sclerosis complex minor criteria

73

Hamartomatous rectal polyps

Tuberous sclerosis complex minor criteria

74

Bone cysts

Tuberous sclerosis complex minor criteria

75

"Confetti" skin lesions

Tuberous sclerosis complex minor criteria

76

Multiple renal cysts

Tuberous sclerosis complex minor criteria

77

Nonrenal hamartoma

Tuberous sclerosis complex minor criteria

78

Cerebral white matter radial migration lines

Tuberous sclerosis complex minor criteria

79

Retinal achromic patch

Tuberous sclerosis complex minor criteria

80

Gingival fibromas

Tuberous sclerosis complex minor criteria