Cancer - tumor suppressants Flashcards
1
Q
function of retinoblastoma Rb
A
is a cell gatekeeper
involved in checking cell division and death
2
Q
how does Rb perform its function
A
binds and inhibits E2F
3
Q
function of E2F
A
its a transcription factor leading to cell division
cyclins and kinases
4
Q
how is E2F released from Rb
A
in G1 phase, if there are lots of cyclin D bound to Cdk4/6, they phosphorylate Rb which releases E2F
5
Q
what is Rb classified as and why
A
canonical tumour suppressant gene
mutations are found in familial cancers
6
Q
function of p53
A
controls:
cell division
apoptosis
DNA fidelity
7
Q
A
