CancerBio 2 Flashcards
(22 cards)
Who understood carcinogenesis?
No one
Carcinogenesis
The process of normal cells being transformed into cancer cells - the initiation of cancer cell proliferation
Mutagenesis
The production of genetic mutations
Cell Transformation
the change in phenotype of a cell due to new genetic material
oncogenesis/ tumorigenesis
the process of healthy cells becoming cancer cells, neoplastic cell states
Fisher and lumpectomy
localized cancer, in god we trust all others must have data, the patients shifted to his theory, proved cutting more does not cure more we need to understand the disease better.
Viral Carcinogenesis Theory
transferring tumor samples into other chickens, break down tissue to cells and still it transferred, he presumed virus
7 cancer causing viruses
Epstein-Bar virus, papilloma, Hep b and Hep c, herpes, hiv, tcell leukemia v-1
Epstein-Barr Virus
Dr. Epstein and Dr. Barr were virologists that found HBV. They analyzed a tumor sample brought from Africa by Burkitt they found virus particles. —vaccines possible?
What propelled the National cancer institutes virus program
epstein barr virus, this did kind of halt progress on other topics
What’s a virus, is it alive?
submicroscopic infectious agent, nucleic acid surrounded by protein, not alive no metabolism no survival independently
Percivall Pott
london doctor who found scrotal cancers from men who all were chimney sweeps. he proposed environmental solution
Bradform and Hill
epidemiologists who interviewed lung cancer patients. –> smoking tabacco.
3 causes of cancer in 1960
virus, environment, hereditary
aneuploidy
total chromosomes doesn’t equal 46
Ames Assay
a test to see which chemicals can mutate genes, uses reverse mutations. mutated bacteria strand he had couldn’t produce histidine . if histidine was seen in mutated.
Who was awards the nobel price in 1989
michael bishop ad harold varmus studied rous-sarcoma virus and found the mechanism of the disease. it had an extra gene, SRC it was what was causing the cancer
Oncogene
a cancer causing gene from virus, came mutation.
ethidium bromide
a non radioactive marker to stain nucleic acid in gel electrophoresis. undone helix
Who discovered first human oncogene?
Robert Wienburn RAS splitting genes into culture from tumor cell to isolate faster.
Describe BCR/ABL
Janet rowley, Philadelphia chromosome. 9 and 22 swap pieces causing CML B cell receptor. Abl is a kinase
Gleevac
Treats cml decreases white blood cells. Competitive inhibitory. It binds and modifies the cell. Pairs with bcr/abl.
