Cancers Flashcards
(38 cards)
Myelofibrosis
Increased megakaryocytes
JAK2 mutation
Tear-drop RBC
Polycythemia Vera
increased RBCs
JAK2 mutation
Decreased EPO
Ruddy face
Aquagenic pruritus
CML
t(9,22) BCR-ABL
Philadelphia chromosome
Imatinib treatment
Waldenstrom-Macroglobuinemia
M spike (IgM)
Bleeding
Neurologic defects (sluggish blood)
Seen in LPL
LPL
B cells that matured into plasma cells incorrectly
Cause Waldenstrom
Diffuse large B-cell
very aggressive
B cells in sheets
Maybe EBV or HHV8
Burkitt
EBV
Starry Sky
t(8,14) c-MYC
t(2,8)
t(8,22)
Marginal Zone
H pylori infection
t(11,18)
Follicular Lymphoma
t(14,18) BCL2
Richter transformation
Mantle Cell
t(11,14)
Cyclin D1 overexpressed
Small cells
Poor prognosis
CD5+
Mycosis Fungoides
Rash, plaques, nodules
Sezary Syndrome in blood
CD4+
Adult T-cell
HTLV-1
Endemic to Japan and Caribbean
Hairy Cell
CLL subtype
BRAF mutation
TRAP +
CLL
Most common overall
CD5+, CD20+
Smudge cells
Hypogammaglobulinemia (infection cause of death)
Richter transformation to diffuse large B-cell lymphoma
APL
AML subtype
t(15,17) blocks maturation by disrupting RAR
Increased DIC risk
Treat with ATRA
AML
TdT-
Myeloperoxidase +
Auer rods
T-ALL
CD2-,10-,8+
B-ALL
t(12,21) favorable
t(9,22) poor
CD2+,10+,19+,20+
ALL
TdT+
Myeloperoxidase -
Common in Kids
Down Syndrome Risk Factor
Increased megakaryocytes
JAK2 mutation
Tear-drop RBC
Myelofibrosis
increased RBCs
JAK2 mutation
Decreased EPO
Ruddy face
Aquagenic pruritus
Polycythemia Vera
t(9,22) BCR-ABL
Philadelphia chromosome
Imatinib treatment
CML
M spike (IgM)
Bleeding
Neurologic defects (sluggish blood)
Seen in LPL
Waldenstrom-Macroglobuinemia
B cells that matured into plasma cells incorrectly
Cause Waldenstrom
LPL
