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Oncology (small) > Canine lymphoma (Yr4) > Flashcards

Canine lymphoma (Yr4) Flashcards

1
Q

what cells does canine lymphoma arise from?

A

T or B cells

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2
Q

what age is canine lymphoma seen?

A

middle age to older dogs

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3
Q

what population of dogs is lymphoma less commonly seen in?

A

entire females (oestrogen protective?)

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4
Q

what is the most common presentation of lymphoma?

A

multicentric

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5
Q

what are the possible presentations of lymphoma?

A

multicentric, craniomediastinal, gastrointestinal, cutaneous, extra-nodal

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6
Q

what is the main clinical sign of multicentric lymphoma?

A

generalised lymphadenopathy (other signs relate to the body systems affected)

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7
Q

what are the main clinical signs craniomediastinal lymphoma?

A

dyspnoea
signs of hypercalcaemia (PUPD, vomiting, tremors…)

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8
Q

what cells form cutaneous epitheliotrophic lymphoma?

A

T cells

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9
Q

what is the distribution of cutaneous epitheliotrophic lymphoma?

A

solitary lesions

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10
Q

what cells form cutaneous non-epitheliotrophic lymphoma?

A

B cells

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11
Q

what is the distribution of cutaneous non-epitheliotrophic lymphoma?

A

generalised lesions

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12
Q

what paraneoplastic syndromes can be seen with lymphoma?

A

hypercalcaemia (mediastinal/alimentary)
immune mediated disease (IMHA, IMTP, pemphigus)
neuropathy
cachexia

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13
Q

how are lymphoma diagnosed?

A

cytology and histopathology

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14
Q

what is the staging system for lymphoma?

A
  1. single lymph node or lymphoid organ
  2. regional lymph node involvement
  3. generalised lymph node involvement
  4. hepatic/splenic involvement
  5. blood, bone marrow or other systems involved
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15
Q

what drugs are used in a high dose COP?

A

cyclophosphamide, vincristine, prednisolone

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16
Q

what are some treatment options for lymphoma?

A

high dose COP
discontinuous CHOP/CEOP

17
Q

what drugs are used in CHOP?

A

cyclophosphamide, doxorubicin. vincristine, prednisolone

18
Q

what drugs are used in CEOP?

A

cyclophosphamide, epirubicin, vincristine, prednisolone

19
Q

what should be examined before treating lymphoma with COP or CHOP/CEOP?

A

bloods
urine (cyclophosphamide)

20
Q

what toxicity does cyclophosphamide cause?

A

sterile haemorrhagic cystitis

21
Q

what toxicity does doxorubicin and epirubicin cause?

A

cardiotoxicity

22
Q

what toxicity does lomustine cause?

A

hepatotoxicity

23
Q
A

Oncology (small) (8 decks)

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