Carbonic Anhydrase Inhibitor Flashcards Preview

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Flashcards in Carbonic Anhydrase Inhibitor Deck (6):
1

Where do they exert their effx?

Proximal tubule

2

Carbonic anhydrase inhibitor prototype?

Acetazolamide; developed from sulfanilamide after it was noticed to cause metabolic acidosis and alkaline urine

3

MOA?

- H+ and bicarb in the tubular fluid can form carbonic acid --> carbonic anhydrase can convert to CO2 and H2O, which can cross the membrane, where CA can break down to H+ & bicarb

- Bicarbonate ions remains in early proximal tubule

- H+ cycling is lost, inhibiting NA+/H+ exchange

4

Pharmacologic effect?

- Sodium bicarbonate diuresis (alkaline urine)

- Hyperchloremic acidosis

5

Therapeutic uses?

- Very limited

- urinary alkinization

- metabolic alkalosis

glaucoma --> acetazolamide, dorzalamide

- Acute mountain sickness

6

Adverse effects of CAI's?

- Hyperchloremic metabolic acidosis

- Nephrolithiasis

- Potassium wasting