Flashcards in Carbonic Anhydrase Inhibitor Deck (6):
Where do they exert their effx?
Carbonic anhydrase inhibitor prototype?
Acetazolamide; developed from sulfanilamide after it was noticed to cause metabolic acidosis and alkaline urine
- H+ and bicarb in the tubular fluid can form carbonic acid --> carbonic anhydrase can convert to CO2 and H2O, which can cross the membrane, where CA can break down to H+ & bicarb
- Bicarbonate ions remains in early proximal tubule
- H+ cycling is lost, inhibiting NA+/H+ exchange
- Sodium bicarbonate diuresis (alkaline urine)
- Hyperchloremic acidosis
- Very limited
- urinary alkinization
- metabolic alkalosis
glaucoma --> acetazolamide, dorzalamide
- Acute mountain sickness