Carcinogens Flashcards

1
Q

Aflatoxin

A

Hepatocellular carcinoma

Derived from aspergillus molds

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2
Q

Alkylating agents

A

Leukemia/lymphoma

chemotherapeutic agents

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3
Q

Alcohol

A

Squamous cell carcinoma (oropharynx, upper esophagus)
Pancreatic cancer
Hepatocellular carcinoma

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4
Q

Arsenic (derived from cigarette smoke)

A

Squamous cell carcinoma of skin
Squamous cell carcinoma of lungs
Angiosarcoma of liver

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5
Q

Asbestos

A

Bronchogenic carcinoma > Mesothelioma

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6
Q

Cigarette smoke

A

Carcinoma of oropharynx, esophagus, lung, kidney, bladder

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7
Q

What component of cigarette smoke is particularly carcinogenic?

A

Polycyclic hydrocarbons

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8
Q

Nitrosamines

A

Stomach cancer

Smoked foods; high rate of stomach cancer in Japan

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9
Q

Naphthylamine (derived from cigarette smoke)

A

Urothelial carcinoma of the bladder

bonus: renal pelvis is also a site of urothelial carcinoma

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10
Q

Vinyl chloride

A

Angiosarcoma of the liver

Used to make PVC pipe

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11
Q

Nickel

A

Lung carcinoma

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12
Q

Chromium

A

Lung carcinoma

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13
Q

Beryllium

A

Lung carcinoma

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14
Q

Silica

A

Lung carcinoma

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15
Q

Ionizing radiation

A

Papillary thyroid carcinoma (orphan annie eye)
AML
CML

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16
Q

Carbon tetrachloride

A

Liver carcinoma

17
Q

EBV

A

Nasopharyngeal carcinoma
Burkitt Lymphoma
CNS lymphoma in AIDS

18
Q

HHV-8

A

Kaposi Sarcoma (AIDS)

19
Q

HBV and HCV

A

Hepatocellular carcinoma

20
Q

HTLV-1

A

Adult T cell leukemia/lymphoma

21
Q

HPV 16, 18, 31, 33

A

SCC of the vulva, vagina, anus, and cervix
Adenocarcinoma of the cervix

(Bonus: E6 inhibits p53; E7 inhibits Rb)

22
Q

Non-ionizing radiation

A

(non-ionizing = UBV from sunlight)
BCC, SCC, melanoma

(Bonus: forms pyrimidine dimers; xeroderma pigmentosum = defective nucleotide excision repair of pyrimidine dimers)