Carcinogens/Oncogenic microbes Flashcards
(23 cards)
Front will have the Carcinogen/microbe and back will have the impact/assoc. cancer
FA pg 231
EBV
Burkitt Lymphoma, Hodgkin Lymphoma, Nasopharyngeal carcinoma, primary CNS lymphoma (in IC pts)
HBV, HCV
Hepatocellular carcinoma (HCC), lymphoma
HHV-8
Kaposi Sarcoma
HPV
Cervical, penile/anal carcinoma (types 16, 18), head/neck ca., SCC of vulva, vagina
(SCC and adenocarcinoma of cervix)
H pylori
Gastric adenocarcinoma and MALT lymphoma
HTLV-1
Adult T-cell leukemia/lymphoma
Liver fluke
Clonorchis sinensis
Cholangiocarcinoma
Schistosoma haematobium
bladder ca. (squamous cell)
Aflatoxins (derived from Aspergillus, which can contaminate stored rice/grains)
Hepatocellular carcinoma
Alkylating agents
Leukemia/Lymphoma
side effect of chemo
Aromatic amines (ie Benzidine, 2-naphthylamine)
Transitional cell carcinoma
Arsenic
Angiosarcoma of liver,
Lung ca.,
Squamous cell carcinoma (SCC) of skin
(arsenic is present in cig smoke)
Asbestos
Bronchogenic carcinoma of lung, mesothelioma
Carbon tetrachloride
Liver: centrilobar necrosis, fatty change
Cig smoke
MC carcinogen worldwide, polycyclic hydrocarbons particularly carcinogenic
Bladder: Transitional cell carcinoma, Cervical carcinoma, Esophagus: SCC, adenocarcinoma, Kidney: Renal cell carcinoma, Larynx: SCC Lung: Squamous cell and small cell carcinoma, Pancreatic adenocarcinoma
Ethanol
Esophagus: SCC
Liver: Hepatocellular carcinoma
Ionizing Radiation
Papillary Thyroid carcinoma, AML, CML
due to generation of hydroxyl free radicals
Nitrosamines (smoked foods)
Gastric ca.
responsible for high rate of stomach carcinoma in Japan
Vinyl Chloride
Liver: Angiosarcoma
occupational exposure; used to make PVC for use in pipes
Naphthylamine
Urothelial carcinoma of bladder
dervied from cig smoke
Nickel, chromium, berryllium, or silica
Lung carcinoma
occupational exposures
Nonionizing radiation
BCC, SCC, and melanoma of skin
UVB sunlight is MC source
