CARD 44- Pharm: Anticoagulant, Platelet Inhibitor and Thrombolytics

Question 1

• What is the MOA of Low molecular weight heparin (LMW)?
• What drug is an example of it
• What effect does it have on factor Xa? Thrombin?
• What are its drawbacks? advantages?

Answer 1

Question 2

Describe the MOA and PK for Fondaparinux

Answer 2

Question 3

What are the GP IIb/IIIa Receptor Antagonists?

Answer 3

ATE GP

Question 4

What are the steps of Hemostasis?

Answer 4

Question 5

What inhibitor platelet aggregation drug does this describe?

Blocks ADP receptors on platelets

Answer 5

Question 6

What is the MOA of Heparin?

Answer 6

Question 7

What are the Pharmacogenomic Considerations: for Warfarin

Answer 7

Question 8

What is the MOA for Warfarin?

Answer 8

Question 9

What are the ADP Receptor Antagonists?

Answer 9

Clones Prepared to be ADePt

Tony the Tiger reversed

Ticagrelor is reversible

Question 10

What inhibitor platelet aggregation drug does this describe?

Blocks formation of TxA2

Answer 10

Aspirin

Question 11

What are the DDIs and ADRs for aspirin?

Answer 11

Question 12

Describe the PKs and ADRs for GP IIb/IIIa Receptor Antagonists

Answer 12

Question 13

How does aspirin affect Cox-1 vs Cox-2?

Answer 13

Question 14

What are the ADRS for Warfarin?

Describe Warfarin reversal

Answer 14

Question 15

What are the “substances”?

Answer 15

Question 16

Where is heparin found?

What are the types of Heparin?

Answer 16

Question 17

What are the PKs for Warfarin?

What do you need to monitor?

What is it used for?

Answer 17

Question 18

What are the DDIs and ADRs for ADP Receptor Antagonists?

Answer 18

Question 19

What are the ADRs of Direct thrombin inhibitors?

Answer 19

Question 20

What are the uses and PKs for Fibrinolytics/Thrombolytics?

Answer 20

Question 21

What is the MOA for GP IIb/IIIa Receptor Antagonists?

Answer 21

Question 22

Describe the MOA, PK, and ADRs for Rivaroxaban

Answer 22

Question 23

What are the 2 substances responsible for stimulating platelet aggregation?

Answer 23

Question 24

What is aspirin used for?

What are its PKs?

Answer 24

Question 25

What are the DDIs for Warfarin?

Answer 25

Question 26

What are PKs for ADP Receptor Antagonists?

Question 27

What is the MOA for Fibrinolytics/Thrombolytics?

Answer 27

Question 28

What are the Factor Xa Inhibitors? What DDI do they all share?

Answer 28

Fondaparinux Rivaroxaban Fond of Rivers

Question 29

What inhibitor platelet aggregation drug does this describe? Blocks the receptor used for platelet aggregation

Answer 29

Question 30

What is Ticagrelor?

Answer 30

A reversible ADP receptor antagonist

Question 31

What are these examples of?

Answer 31

Warfarin

Question 32

What are the Direct thrombin inhibitors and their PKs?

Answer 32

Dab Again

Question 33

What molecules do Antiplatelet agents inhibit?

Question 34

What are the DDIs and ADRs for Low molecular weight heparin (LMW)?

Answer 34

Question 35

What is the MOA of Unfractionated heparin (HMW)? What effect does it have on factor Xa? What are its drawbacks?

Answer 35

Question 36

What receptor do platelets use to attach to one another?

Answer 36

Question 37

What are the uses of Direct thrombin inhibitors? What use is specific for Dabigatran?

Answer 37

Question 38

What are the Fibrinolytics/Thrombolytics?

Answer 38

ART PLASE

Question 39

What are the types of Anticoagulants and what are they used for?

Answer 39

Question 40

What are the Hemostatics? What are they used for and what their MOAs?

Answer 40

Question 41

What is Streptokinase? Describe its PKs and ADRs

Answer 41

Question 42

What do you use GP IIb/IIIa Receptor Antagonists for?

Answer 42

Patients with recent MI or stroke or PCI

Question 43

What is the MOA for ADP Receptor Antagonists?

Answer 43

Irreversibly inhibit ADP receptor on surface of platelets (necessary for platelet aggregation)

Question 44

What is the MOA for Aspirin?

Answer 44

Question 45

What are ADP Receptor Antagonists used for?

Answer 45