Cardiac Flashcards

(46 cards)

1
Q

Pharmacologic Management for CAD pts? Anesthesia implications of normal pharmacologic mgmt?

A

Get good H&P- confirm current med management

  • Beta blockers
    • reduce contractility and HR
    • Make sure they’re still taking
  • CCB
    • dilate coronary arteries
    • reduce contractiliy
    • reduce afterload
  • ACE inhibitors
    • imporve contractility by afterload reduction
    • 1st line for HTN and DM
    • Can cause intraop HoTN- d/c 24 hours before
  • Nitrates-
    • dilate coronary arteries and collateral blood vessels
    • decrease peripheral vascular resistance (decreases afterload)
    • vendodilation (decreases preload)
  • Antiplt drug
    • reduce potential for thrombosis
    • consider INR and ability to perform regional
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2
Q

Periop MI risk?

A
  • Risk of periop death d/t cardiac cause is <1% ingeneral population
  • Most periop MIs occurs in frst 24-48 hours after surgery
    • d/t pain, stress, no anesthesia
    • don’t set them up for failure- use appropriate adjuncts
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3
Q

What time shoudl you wait for elective surgery after angioplasty without stent, BMS placement, CABG, Drug-eleuting stent placement?

A
  • Angioplasty without stenting- 2-4 weeks wait
  • Bare metal stent placement- wait at least 30 days; 12 weeks preferred!
    • 3 months ideal
  • CABG- wait 6 weeks; 12 weeks preferred
    • frequently CABG done before elective sx
  • Drug eluting stent placement - at least 12 months
    • drug eluting stnet has antineoplastic/abx coverage that dissolves in few weeks–> month, prevent rethrombose/PLT aggregation
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4
Q

What causes decreased O2 supply?

A
  • Tachycardia (decrase diastolic time)
    • treat underlying cause to treat tachycardia! (pain, hypovolemic, anemic, etc)
  • hypotension- decrease perfusion pressure to heart
  • vasoconstriciton- avoid phenylephrine
  • O2 carrying capacity
    • acid/base
    • anemia- replace blood with blood!
    • hypoxia FIO2 >70%
  • Viscosity- dry, more resistance in vessel, decrease supply
  • Arterial patency- can’t control, underlying condition
  • coronary spasm- avoid by reducing stress by preemptic analgesia
    • esp in areas with atherosclerosis. avoid drugs that cause coronary spasm and use drugs like CCB to help increase supply by reducing vasospasm
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5
Q

What are factors that increase O2 demand to heart?

A
  • Tachycardia (this one is also on decreased supply list)
  • Increase Contractiilty- b blockers
  • increased preload- normal volemic patient
  • increased afterlaod
  • shivering- increase metabolic demand
    • keep pt warm
  • hyperglycemia- tight control
    • manage SNS to prevent hyperglycemia
  • HTN- d/t pain
    • treat pain! manage BP!
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6
Q

Goal of managing O2 supply and demand to heart?

A

Prevent tachycardia and treat immediately because it’s the only one that affects both supply and demand negatively

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7
Q

What is first step to decide if CAD pt can proceed to sx?

A
  • Determine if emergent or urgent:
    • optimiize medical management/proceed to surgery
  • If Elective:
    • unstable CAD (major clinical risk factors and/or change in cardiac condition
      • cardiology consultation
    • Stable - next slide
      • determine exercise tolerance, see next slide for further info
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8
Q

Pt with stable CAD is having elective sx, what are steps to determine if further testing necessary?

A
  • Determine exercise tolerance
  • High or intermed risk sx and moderate to minor clinical risk factors
  • if prior revascularization
    • cabg
      • < 5 yr, no change in medical condition
        • no need for stress test, proceed to sx
    • PCI
      • BMS > 6 wk- minimal antiplatleet therapy; no change
        • no need stress test, proceed to sx
    • DES <12 MO AND dual antiplt therapy
      • consult cardiology to blaance risk of thrombosis and/or bleeding
  • If no prior revascularization
    • statify risk further (see next slide)
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9
Q

How do you determine If stable CAD with no prior revascularization can proceed to sx?

A
  • If high or intermediate risk sx or moderate clinical risk factors with no prior revascularization
    • stable CAD (medically optimized or good exercise tolerance)
      • no need to stress test
      • proceed to sx
    • unable to assess CAD or decreased exercside tolerance
      • noninvasive testin (stress test)
        • if positive–> cardiac cath
        • if negative–> proceed to sx
  • If cath shows left mian or equivalent disease–> multidisciplinary approach
    • consider risk of noncardiac sx vs coronary revascularization
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10
Q

Anesthetic mgmt for pt with CAD?

A
  • Regional
    • tx hypotension with phenylephrine- okay for short periods
    • if bradycardic- use ephedrine
  • General
    • maintain blanace b/w supply and demand
    • do not allow for long periods of hypotention
    • Wake up warm, don’t overload with fluids, don’t admin too much phenyl and cause increase afterload
  • IMPORTANT TO MAINTAIN BP WITHIN 20% OF PT BASELINE!
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11
Q

How do you appropraitely monitor for ischemia in sx?

A
  • EKG 5- lead at least for angina
  • See table for leads, coronary artery responsible and area of myocardium involved. probably wise to memorzie for test ;-)
  • Dr. E mentioned II. III, V5 being most ideal to monitor for ischemia; these are the areas with increased likelihood for ischemia
    • ​II, V5 give idea of inferior and anterolateral aspect of heart
      • that side is more muscular, in diastole, doesn’t fill as proficiently
  • If specific area has hx ichemia, then minotr that area (ie, circumflex, monitoring I, avL)
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12
Q

Induction of patient with CAD?

A
  • minimal hemodynamic effect (no wide swings in BP!)
    • keep duraiton of laryngoscopy short!
    • minimize response
      • opioids upfront
      • LTA, IV lidocaine, before DL
      • Be efficient, no significant changes to your technique
      • deep, smooth induction
  • Severe cardiac dysfunction
    • etomidate
    • high opioid technique
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13
Q

Anesthesia maintenance of pt with CAD?

A
  • AVOID TACHYCARDIAS!
  • Preload- normal
  • afterload- normal
  • contractility- decrease if LVF is normal- if LVF is reduced, don’t mess with it
    • continue BB unless LVF decrease
  • HR- avoid increases
  • Rhythm- NSR is best,<– rely on atiral kick
  • MVO2- controlling demand is easier than supply, attenuate sympathetic outflow
    • focus on controlling (decreasing) DEMAND in CAD pt
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14
Q

Intraoperative considerations for CAD pt?

A

All patients undergoing sx will have normal inflammatory response and neuroendocrine stress response. Focus on managing effects of these responses:

  • Inflammatory response
    • hypercoaguable state, plaque rutpures–> thrombus /embolus
      • decreased HCT, hypoxia, vasoconstriciton, decreased BP all contribute to decreased O2 delivery
  • Neuroendocrine response
    • Increase HR increase BP, metabolic changes
    • postop shivering
    • all cause increase O2 demand
  • Decreased O2 delivery and increased O2 demand–> perioperative myocardial injury/infarction which can show up 1-2 days postop!!

To minimzie response intraop:

  • Smooth anesthetic
    • No big fluctuates in HR/BP
    • Admin
      • Opioids
      • intraop tylenol
      • toradol
      • steroids
  • Wake up pain free
  • keep pt warm
  • address blood loss
  • keep well oxygenated!
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15
Q

What is definition of hypertensive crisis? Treatment?

A

Definition: sudden increase in diastolic BP above 130 mmHg

  • due to: activation of RAAS system<– usually what sets off crisis

TREATMENT:

  • Prompt, but controlled reduction in BP with NTP (SNP) 0.5-10 ug/kg/min
  • Monitoring UOP (foley) and insertion of intraarterial BP
  • Decrease DBP carefully to 100-110 mmHg over several min to hours<– don’t want to drop too quick!
    • Meds:
      • SNP 0.5-10 ug/kg/min
        • DOC, short DOA
      • NTG 5-200 mcg/min
      • Labetalol 40-80 mg q 10 min
        • careful, don’t want to BB heart!! use with arterial dilator like SNP!!
      • Esmolol 50-300 MCG/KG/MIN
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16
Q

Quesitons to consider for anesthetic managmenet of HTN patient?

A
  • Controlle vs uncontrolled HTN?
  • Emergent vs elective sx?
  • Evidence of end-organ damage?
    • angina
    • CHF- problematic d/t increased M/M r/t recent CHF exacerbation
    • CVA- how long ago? what weakness, mentla status?
    • Renal insufficiency- HTN often has renal insuff. Do you expect big fluid volume shifts intraop? may want foley/aline
    • PVD
  • Drug regmien?
    • BB? ACE? ARB? CCB? Did they take them?
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17
Q

Management of anesthesia for HTN pt?

A
  • Preop eval
    • determine adequacy of systemic BP control
    • review pharmacology of drugs being admin to control systemic BP (orthostatic hypotension, bradyacrdia, sedation_
    • Evaluate for evidence End organ damage
      • angina
      • LVH
      • CHF
      • CVA
      • PVD
      • Renal insufficiency
  • Induction
    • anticipate exaggerated systemic BP
    • Limit duraiton DL to avoid HTN
  • Maintenance anesthesia
    • admin VA to blune HTn response
    • monitor for MI
  • Post op
    • anticipate periods of systemic HTN
    • maintain monitoring of end organ function
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18
Q

Induction goals for HTN patient?

A
  • Goal is to minimize SNS stimulationw ith laryngoscopy and intubation
  • attenuate laryngeal reflexes with additional narcotic, increase VA, and lidocine (topical or IV)
  • How?
    • choice of any induction agent is appropriate EXCEPT ketamine (Increase SNS resposne)
    • Lidocaine IV 1-1.5 mg/kg
    • Lidocaine Topical LTA 2-4%
    • opiates
    • VA
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19
Q

Maintenance goals in patient with HTN?

A
  • Goal is to adjust depth of anesthesia to minimize wide shifts in hemodyanmics
    • drop Bp right before DL because it will get dramatically high with DL
  • Be prepared for wide shifts- typical with HTN patients
  • How?
    • Choose IA that is easily adjusted (des, sev)
    • Balanced technique
    • have ephedrine, neosynephrine readily available
    • consider neo gtt if unable to get adequate depth of anesthesia
      • used to living at higher perfusion pressure, keep BP within 20%!!
20
Q

Postop consideration for pt with HTN?

A
  • Goal is to minimize SNS secondary to srugical pain and n/v
  • no shivering!!
21
Q

Intraop HTN treatment?

A
  • Usually d/t pain!
  • incidence is higher in pt with essential HTN
  • treatment:
    • narcotics- if pain is obvious cause
    • IA
    • BB
    • NTG
    • Nipride
22
Q

Treatment of intraop hypotension?

A
  • Decrease aneshtesia depth
  • fluids
  • sympathomimetics
  • check rhythm–> is it junctional? sometimes pt go into junctional rhythm under anesthesia, unsure exact mechanism
    • maintain normocapnia
    • avoid high concentration of IAs
23
Q

Monitoring of HTN pt?

A
  • 5 lead EKG
  • A line, CVP, PA cath if extensive sx and venricular dysfunction
  • TEE
24
Q

Emergence of pt with HTN?

A
  • Controlle emergence
  • minimize sympathetic outflow- every HTN pt will wake up HTN
    • use of narcotics
    • use of lidocaine
    • use of labetalol, esmolol, NTG
    • Deep extubation- if possible
25
Post op HTN treatment?
* Pain adeuqately controllw? * if yes, then HTN treat with * hydralazine 2.5-10 mg IV q 10-20 min * labetalol 5-20 mg IV q 10 min * Nipride 0.5-10 mcg/kg/min
26
Peripheral revascularization for peripheral vascular disease (PVD)
* Preop: * *Assess HTN and CAD r/f for PAD* * *Exercise tolearance, pain, claudication with exercise? blood thinners?* * *Intraop:* * After donor and recipient arteries exposed, tunnel is created and graft is passed * graft may be saphenous vein or prothesis * *own vessel doesn't work that well because probably also atherosclerosed* * Heparin IV given * *typically give 3,000-5,000 units* * Anastomosis are constructed * arteriogram to confirm adequate flow- *doppler peripherally to confirm adequate flow* * *​*maintain good BP in these pts! * heparin is not likely to be reversed * Principle risk during reoncstructive sx is associated with **atherosclerosis**, especially **IHD** * **Pt with PVD has 3-5greater risk of MI, stroke and death!** * *need good exercise tolerance! cleared by cards, stress test, etc* * *have to manage both PVD and CAD!* * **CABG operations are usually performed before sx on peripheral vasculature pt who experience angina and claudication**
27
What is important in management of PVD pt?
skill and experience of anesthesia provider, including the ability to monitor hemodynamics and respond quickly, are far more important than a specific agent used
28
Preferred anesthesia technique for PAD pt?
* Regional anesthesia: some perceived advantages of regional anesthesia 1. increased graft blood flow * *sympathectectomy below level of regional* 2. less increase in SVR with cross clamping 3. Postop pain relief- *this also protects SNS outflow* 4. Less activation of coag system * *decrease plt activation* * *decrease resistance in blood flow* * *preferrable mechanism- consider anticoag/antiplt meds pt on!* * *Regional vs General* * assess for coag * if consideration regional, spinal may be best, to avoid hematoma * studies have shown no diff b/w RA and GA in terms of CARDIOPULMONARY complications * *no diff in MI, death, myocardial ischemia outcomes b/w regional and GA* * sig difference in complication rate in terms of GRAFT OCCLUSION * *pt c reigonal do better with graft and graft sx outcome* * *surgeons want regional*
29
Anesthetic management of PAD?
* Consider co morbiidties- biggest CAD * CVA, renal, etc? * medication hx- impact on anesthetic delivery * *anticoag--\> if increased INR, no regional* * end organ perfusion and oxygenation-- maintain * *kidney, brain* * blood gases- electolyte and pH changes * cross clamp- hep admin/record time/reversal? * give heparin (3-5000 max) * record time--\> heparin peaks 3-5 min after, let surgeon know and they'll cross clamp * typically no reversal needed unless higher doses given
30
Peripheral revascularization monitoring?
* Pt typically present with CAD, DM, HTN * *tight BG control* * Preop- make sure pt takes BB and/or other chronic meds * intraop a line- *useful if labile BP and bypassing large vessels, long case* * ability to monitor intravascular volume by either CVP and CO or urinary catheter * *esp is underlying cardiac issues* * *foley with longer cases esp.* * EBL- *keep eye on blood loss. if not clamping adequately, may get quite a bit of bleeding* * estimated third space * *wounds can be large OR sometimes small incisions* * *keep eye on third spacing*
31
Goal of managmenet of mitral stenosis pt?
**_Goals (slow tight full)_** 1. Avoid sinus tachycardia or rapid ventiruclar response rate during a fib * *Stoelting- treat afib c rvr with amiodarone, bb, ccb* 2. avoid marked increases in central blood bolume as associated with over transfusion or head-down position * *no rapid transfuion or head down* * *dont' want drop or sudden increase in prelaod!* 3. avoid drug induced decreases in SVR * *use etomidate- any decrease in SVR, hypotension is very difficult to manage, need to treat adequately with phenylephrine* 4. Avoid events such as arterial hypoxemia and/or hypoventilation that may exacerbate pulmonary HTN and evoke RV failure * *​will easily back up into pulmonary system!* * *100% o2 prudent on these pt* * *Stoelting- events that increae pulm HTN=* * *​Hypoxemia* * *hypercarbia* * *lung hyperinflation* * *increase lung water*
32
Induction of anesthesia in pt with Mitral stenosis?
* Most often accomplished with drugs admin intravenously that are unlikely to increase HR (avoid ketamine) or abruptly decrease SVR (*want to maintain tight system)* * *​ideal- etomidate, high narcotic technique*
33
Maintenance of anesthesia with mitral stenosis?
* Is intended to minimize the likelihood of marked and sustained changes in HR, SVR, PVR and myocardial contractility * useful drugs * beta blockers * ccb * phenylephrine * Use of invasive monitoring depends on complexity of the operative procedure and the magnitude of physiologic impairment produced by mitral stenosis * *aline useful----degree of invasive monitoring depends on procedure and sx impairment* * *if very severe MS and non-cardiac related procedure, is the procedure worth doing before valvular replacement?* * *If sx needs to be done and MS isn't so severe* * *​aline* * *CVP line useful* * *if bigger procedure--\> cardiac consult esp if mitral stenosis severe*
34
What intraop events do you need to avoid with MS?
* Sinus tachycardia or rapid ventricular response during atrial fib * *BP will instantly drop* * marked increase in central blood volume, as associated with overtransfusion or head down positon * drug-induced decrease in SVR * *If Bp drops, hard to get blood flow back* * hypoxemia and hypercarbia that may exacerbate pulmonary HTN and evoke RV failure
35
Aortic stenosis general management goals of anesthesia?
* Important goal-- avoid events that would further **decrease CO** Goals (*slow, tight, full like MS??)* 1. maintain NSR 2. AVOID bradycardia or tachycardia * hr 60-90 hr DEPENDENT on BP 3. avoid hypotension * *If lose BP, like MS, will get into trouble* 4. optimize intravascular fluid volume to maintain venous return and LV filling * *​need good venous return! help with SV and forward flow* * *don't overload either!*
36
Gen vs regional in aortic stenosis?
* General anesthesia is often selected in preference to epidural or spinla anesthesia * this minimies the likelihood of an undesirable decrease in SVR * *sympathemectomy with spinal causes lots of issues with AS!* * Use of a-line and PA catheter depends on magnitude of sx and the severeity of the aortic stenosis * *BIG procedure, severe AS and can't replace before urgent/emergent sx, make sure you have PA, a line and moniroting (TEE may also be useful)*
37
Goal of management of anesthesia with Mitral regurgitation?
* Important goal is to avoid events that may further decrease CO GOAL : **FAST FULL FORWARD** 1. Avoid sudden decrease in HR * HR 80/85 beneficial 2. Avoid sudden increase in SVR * *need good forward flow* * *if you decrease BP, hard time getting them back* * *also avoid sudden increases* 3. Monitor the size of the V wave as a reflection of regurgitant flow 4. minimize drug induced myocardial depression * *want balanced technique, with opioid, some VA, nsaids, tyneol etc.* * *no high VA*
38
Induction of anesthesia in mitral regurgitation?
Keep in mind the importance of avoiding excessive and abrupt changes in SVR or decrease in HR * *Keep those things in mind when choosing drugs* * *Etomidate is best bet- no change in BP/HR*
39
Maintenance of anesthesia with mitral regurg?
* Maintenance of aneshtesia- is influenced by degree of LV dysfunction * If LV dysfunction **_not_** severe: * N2O plus VA (isoflurance is attractive choice because of hemodynamic effect) * LV dysfunction severe: * use of opioid technique- minimizes likelihood of drug-induced myocardial depression, may be a consideration * Use of invasive monitorign- depends on: * compelxity of procedure * magnitude of physiologic impairment with MR
40
Anesthetic management of aortic regurgitation?
Goals: * avoid sudden decrease in HR (high normal) * avoid sudden increase in SVR - *blood will go back* * minimize drug induced myocardial depression
41
Induction of anesthesia with aortic regurg?
* Use drugs considered likely to maintain forward LV stroke volume * *etomidate- cardiac stable*
42
Maintenance of anesthesia with aortic regurg?
* If no severe LV dysfucntion * N2O plus VA (isoflurane attractive choice d/t minimla hemodynamic effects) * When myocardial function compromised * use of opioid alone may be considered
43
In a pt with aortic regurg, how aggressively should replace fluids? What physiologic state requires prompt treatment? What determines the monitoring needed in an aortic regurg patient?
* **_Prompt_** replacement of blood loss important to maintain forward LV stroke volume * *if losing blood, repalce blood!* * bradycardia may require prompt treatment with atropine (or glyco) * Monitoring is dictated by * complexity of sx * severeity of aortic regurg
44
Goal of anesthetic managmenet in patient with HF?
Goal is to prevent and avoid myocardial depression 1. HR- normal to elevated 2. Preload- normal to high! * *​if drop preload, then low SV* 3. Afterload- low * *​don't want open-wide system, if drop BP too much, hard time getting back* * *also want to decrease afterload to decrease workload on heart* 4. Contractility- increase
45
Anesthetic management HF?
* Maintain med therapy- esp BB * Hypotension treated with: * ephedrine * phenylephrine * vasopressin * GA doses may be decreased (VA, induction) * PPV beneficial in decreasing pulmonary congestion * regional anesthesia ok * *if regional and decrease in afterload, be careful because if BP dropped too much, hard time getting it back up* * Avoid fluid overload * +/- arterial line * *depends on severity of dx and procedure*
46
Anesthetic management in IHHS?
* VA good - *decrease contractility* * *​these hearts are too muscular and VA is helpful in decreasing contractility* * A-line **MUST HAVE** * Treat hypotension with alpha adrenergic agonists (phenylephrine) and VOLUME! * Beta adrenergic agonists are **contraindicated** * **​*I****f hypotensive, avoid beta agonists because if they are hypotensive, they're usually hypovolemic!!! Beta agonists will just make hypertrophy worse!!* * prompt replacement of blood and fluids * avoid vasodilators * maintain NSR