cardiac muscle mechanics Flashcards Preview

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Flashcards in cardiac muscle mechanics Deck (17)
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1
Q

co=

A

HR*SV

2
Q

SV=

A

EDV-ESV

3
Q

ESV

A

amount remaining in heart after systole

4
Q

EDV

A

amount filled

5
Q

what affects EDV

A

preload

6
Q

what affects ESV

A

after load and inotropy

7
Q

preload

A

initial stretch prior to contraction, ventricular wall, max stretch = EDV/EDP

8
Q

starling law

A

more enters, more ejected (heterometric… related to sarcomere length)

9
Q

what regulation is related to sarcomere length

A

heterometric

10
Q

starling Mech.

A

myofilament overlap, length dep. activation

11
Q

compliance is related to

A

preload, less at higher volume…

12
Q

after load

A

mainly aortic pressure, load against heart ejection

13
Q

what increases afterload

A

pressure and hypertrophy

14
Q

isotropy is dependent or intependent?

A

independent!!

15
Q

what slope is inotropy related to

A

ESVPR

16
Q

what affects isotropy?

A

sympa/para… affect contraction

17
Q

MOA of inotropy

A

increased Ca++ delivery, increased binding, increase crossbrige activity