Cardio Flashcards

(47 cards)

1
Q

echo findings of ie

A

oscillating mass on valve or adjacent structures, myocardial abscess, dehiscence of valves

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2
Q

risk of stent thrombosis duration of anticoagulation - bare metal stent/ des

A

bare metal stent - 1 month; drug eluting stent 1yr

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3
Q

prolonged qt definition and computation

A

bazzett’s formula - qt/sqrt of rr interval; male >0.45 sec female >0.46sec

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4
Q

Heparin dosing for mi vs vte

A

Mi - 60/12
Bolus: 60mg/kg then 12mg/kg/hr
Ptt 1.5-2 times of control

Vte - 80/18
Bolus: 80mg/kg then 18mg/kg/hr
Ptt 2-3 times control

Vte prophylaxis
5000units bid

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5
Q

2 most common autosomal dominant genetic mutations if vte

A
  1. Factor V leiden - activated protein c resistance

2. Prothrombin gene mutations

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6
Q

Most common cause of acquired thrombophilia

A

Antiphospholipid antibody syndrome

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7
Q

Each 2hr per day increment in watching tv increases risk of fatal pe by

A

40%

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8
Q

Most common gas exchange abnormalities in pe

A
  1. Hypoxemia

2. Increased a-a gradient

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9
Q

Causes of rise in pulmo artery pressure in pe

A
  1. Obstruction

2. Release of neurohormonal mediators - serotonin

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10
Q

Classification of pe

A

Massive pe (5-10%) - cardiogenic shock
*involves at least half of pulmo vasculature
Submassive pe (20-25%) - rv dysfunction but normal bp
Low risk pe (65-75%) - excellent prognosis

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11
Q

Most common symptom of pe

A

breathlessness

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12
Q

Most common symptom of dvt

A

Cramps

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13
Q

Diagnostic test for Low likelihood of vte

A

D dimer

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14
Q

High likelihood of vte diagnostic to request

A

Imaging (ctpa)

For wells score >4

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15
Q

Syndrome - Compression of the left proximal iliac by the right proximal iliac

A

May thurner syndrome

- presents with recurrent left thigh edema

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16
Q

Sensitivity of d dimer for pe and dvt

A

Dvt 80%
Pe 95%
D dimer less sensitive than pe because dvt thrombus size is smaller

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17
Q

Ecg abnormality pe

A

Sinus tachy - most common
S1q3t3 - specific
Rv strain and ischemia - most common abnormality t wave in version v1-v4

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18
Q

Cxr findings in pe

A

Hamptons hump - peripheral wedged shaped density
Westermarks sign - focal oligemia
Pallas sign - enlarged right descending pulmo artery

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19
Q

Ct scan finding associated with increased mortality in pe

A

Rv enlargement

*ct scan with iv contrast principal imaging test in pe

20
Q

Triple rule out ct

A

Ecg synchronized acquisition

Rules out 3 major cause of chest pain: pe, mi, acute aortic syndrome

21
Q

Lung scanning component andndiagnostic criteria

A
  • ventilation scan: xenon or krypton labeled gas
  • perfusion scan: particulate aggregates of albumin labeled with a gamma emitting radionuclide
    High probability scan for pe: 2 or more segmental perfusion defects in the presence of normal ventilation
22
Q

Pe sign in 2d echo

A

McConnells sign: hypokinetic rv free with hyperkinetic rv apex

23
Q

Pulmonary angiogram pe finding

A

Intraluminal filling defect in more than 1 projection

24
Q

Study which evaluates efficacy of anticoagulation vs catheter directed thrombolysis in preventing post thrombotic syndrome

25
graduated stocking appropriate pressure and duration of use for dvt
30-40mmhg | 3 months - replace because garter loosens
26
Risk strat of pe and treatment
Normotension with normal rv: anticoag, ivc filter Normotension with rv hypokinesia: individualized Hypotension: anticoag + thrombolysis, embolectomy
27
Treatment for heparin induced thrombocytopenia
Direct thrombin inhibitors: argatroban and bivalirudin
28
Enoxaparin dose for mi and pe
Same for both 1mg/kg bid
29
Warfarin moa
Inhibits vitamin k epoxide reductase and prevents carboxylation activation of vit k dependent factors (2, 7, 9,10)
30
Warfarin pharmacogenomics associated genetics
Cyp2c9 impair hydroxylation and metab of s-warfarin and lpwers requirments Gene: vkorc1 (vitamin k epoxide reductase complex 1)
31
Warfarin dosing
Requires 5 days overlap with either ufh, lmwh, fondaparinux or iv direct thrombin inhibitors even if already on target inr (2-3) May d/c overlap once 2 consecutive inr witjin target Usual starting dose 5mg
32
Fondaparinux moa
Anti-Xa pentasaccharide | Synthesized and not derived from animal products - does not cause heparin induced thrombocytopenia
33
Noacs dose for treatment of vte
No bridge with parenteral - rivaroxaban 15mg bid x 3 wks then 20mg od - apixaban 10mg bid x 1 wk then 5mg bid
34
Reversal agents in treatment of vte Ufh/lmwh Dabigatran Universal reversal agent for anti xa agents
Ufh/lmwh - protamine sulfate Dabigatran - idarucizumab Universal reversal agent for anti xa agents - andexanet
35
Duration of therapy and target inr pe
Target inr = 2-3 Upper extremity dvt or provoked lower extremity (calf) dvt - 3 months Proximal leg dvt - 3-6 months Cancer and vte - indefinitely or until on remission Unprovoked - indefinite duration **note: vte during long air haul travelnis considered unprovoked Apas - indefinite
36
Study which showed provoked vte derived greater risk reduction with extended anticoagulation
EINSTEIN CHOICE
37
2 principal indications for ivc
1. Active bleeding which precludes anticoagulation | 2. Recurrent venous thrombosis despite anticoagulation
38
Common complication of ivc filter
Recurrent dvt or caval thrombosis
39
Volume to infuse for massive pe with hypotension, and first line pressors to use if nonresponsive
500cc nss | Dopamine and dobutamine
40
Fibrinolysis indications in pe and dose
Massive pe only | Tpa 100mg iv over 2hrs
41
Types of respiratory failure
Type 1: hypoxemic Type 2: hypercarbic Type 3: perioperative Type 4: hypoperfusion of respi muscles in shock
42
Ards treatment: Tidal volume Shown to improve survival Decrease days on mv
Tidal volume - 6cc/kg Shown to improve survival - 1. Prone positioning 2. Neuromuscular blockade Decrease days on mv - fluid conservative over fluid liberal strategy
43
Screening test for spontaneous breathing trials in mv patients
- pao2/fio2 >200 and peep <5 - off sedatives - off pressors
44
Spontaneous breathing trial method
Cpap 5 cmh20 and open t piece x 30-120min
45
Failed sbt
- rr >35 x >5min - hr >140 or >20% increase from baseline - sbp <90 or >180 - o2 sat <90 - diaphoresis or anxiety
46
Rsbi (rapid shallow breathing index)
Rsbi = Rr/tv in ml | <105 : higher likelihood of successful extubation
47
Normal ef Normal end diastolic volume Normal end systolic volume
Normal ef 67 +/-8% Normal end diastolic volume 75 +/- 20cc Normal end systolic volume 25 +/- 7