Cardiology

Question 1

What is entresto? What are its indications?

Answer 1

Sacubitril/Valsartan (neprilysin inhibitor/ARB).
HFrEF (<40%): mortality benefit when replaced ACE-i. Also replaced ARB. Can start entresto instead of either when initiating therapy.

Question 2

Common indications for ppm placement

Answer 2

symptomatic bradycardia without reversible cause
permanent atrial fibrillation with symptomatic bradycardia
alternating bundle branch block
complete heart block, high-degree atrioventricular (AV) block, or Mobitz type 2 second-degree AV block, irrespective of symptoms.

Question 3

What is cilastazol? In which patient is it contraindicated?

Answer 3

Phosphodiesterase inhibitor, antiplatelet and vasodilatory properties
Contraindicated with heart failure

Question 4

Treatment regimen for peripheral artery disease and intermittent claudication

Answer 4

Smoking cessation
Supervised exercise regimen
Statin
Antiplatelet monotherapy (ASA or clopidogrel)
Cilastazol (contraindicated with heart failure)

Question 5

Adenosine-based vasodilatory agents for stress testing is contraindicated with which disease?

Answer 5

Asthma / reactive airways disease

Question 6

Holosystolic murmer, left sternal border, obliterates S2

Answer 6

Ventral septal defect