Cardiology Flashcards
(168 cards)
What causes atherosclerosis?
Chronic inflammation and activation of the immune system-> lipid deposition-> atheromatous plaques
What do atherosclerotic plaques cause?
- Stiffening of the artery wall (hypertension and heart strain)
- Stenosis + reduced blood flow (angina)
- Plaque rupture + thrombus (ischaemia)
Non-modifiable risk factors for atherosclerosis?
Older age, family history, male
Modifiable risk factors for atherosclerosis?
Smoking, alcohol, diet, low exercise, obesity, poor sleep, stress
Medical comorbidities that increase the risk of atherosclerosis?
Diabetes, HTN, CKD, inflammatory conditions (eg RA), atypical antipsychotics
Primary prevention of CVD?
- When never had CVD before
- QRISK 3 score
- Give atorvastatin 20mg when-> 10% risk or more, CKD, T1DM
When should statins be stopped (in terms of LFT results)?
When ALT/AST rise to more than 3x upper limit of normal
Secondary prevention of CVD?
4A’s-> Aspirin (+clopidogrel for 12 months after event), Atorvastatin 80mg, Atenolol (or bisoprolol), ACE inhibitor (eg ramipril)
Side effects of statins?
- Myopathy
- Type 2 DM
- Haemorrhagic strokes
- Deranged LFTs
- Rhabdomyolysis
What is stable angina?
- When a narrowing of the CAs reduces blood flow to myocardium causing symptoms
- Stable when symptoms relieved by rest or GTN spray
Gold standard investigation for stable angina?
CT coronary angiography
Baseline investigations in stable angina?
Examination, ECG, FBC, U+Es, LFTs, lipid profile, TFTs HbA1C, fasting glucose
General management for stable angina?
RAMP-> refer to cardio, advise about management, medical treatment, procedure/surgery
Medical management of stable angina?
- Immediate relief-> GTN spray, repeat after 5 mins, call 999 if still pain
- Long term-> beta-blocker or CCB, or long acting nitrate, ivabradine, nicorandil etc
- Secondary prevention-> aspirin, atorvastatin, ACE inhibitor
What does primary PCI entail?
- Percutaneous coronary intervention (PCI) with coronary angioplasty (dilate vessel with balloon and/or stent)
- Catheter via brachial or femoral artery
- Contrast injected
What is CABG?
- Coronary artery bypass graft
- Graft vein from leg (eg great saphenous vein) + sew onto CA to bypass stenosis
- Leaves midline sternotomy scar
What does the RCA supply?
RA, RV, inferior of LV, posterior septal area
What does the circumflex artery supply?
LA and posterior LV
What does the LAD artery supply?
Anterior LV + anterior septum
Diagnosis of STEMI?
ST elevation or new LBBB on ECG
Diagnosis of NSTEMI?
- ST depression, T wave inversion or pathological Q waves on ECG
- Raised troponin levels
Diagnosis of unstable angina?
Symptoms but no ECG changes or raised troponin
Symptoms of ACS?
- Central crushing chest pain, sweating, N+V, SOB, palpitations, pain radiating to jaw/arms
- Symptoms usually last 20+ minutes at rest
What is a silent MI?
ACS in a diabetic patient-> might not get typical chest pain