Cardiology Flashcards

(41 cards)

1
Q

Which main coronary supplies the following:
1) SA node
2) AV node

A

1) Proximal RCA (65%) or LCx (25%), both (10%)
2) RCA (80%), LCX (10%), both (10%)

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2
Q

Average HR drop during sleep in [1] young healthy adults and [2] elderly?

A

24 bpm
14 bpm

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3
Q

Symptoms of Bradycardia?

A

Asymptomatic
Fatigue
Weakness
Light-headedness
Syncope

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4
Q

Physical findings of bradycardia?

A

Slow pulse rate
Hypotension
Cool extremities
Cannon A waves (in setting of AV dissociation)

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5
Q

What is a junctional escape rhythm?

A
  • Rhythm 40-60bpm
  • No visible P waves before QRS
  • QRS typically <120ms
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6
Q

Causes of sinus bradycardia? (intrinsic vs extrinsic to SA node)

A

1) Intrinsic to SA node
- idiopathic degeneration (aging)
- ischemia (esp. inferior)
- infiltrative (e.g., amyloidosis)
- collagen vascular disease (e.g., SLE)
- infectious (e.g., Chagas, myocarditis, Lyme)
- myotonic dystrophy
- surgical trauma (e.g., valve replacement)

2) Extrinsic to SA node
- meds (e.g., bb, ccb, digoxin, clonidine, amio, opioids)
- lytes (e.g., low/high K+)
- neurally-mediated reflexes (e.g., carotid sinus hypersensitivity)
- hypothyroidism
- hypothermia
- brainstem herniation

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7
Q

Common meds associated with sinus bradycardia?

A
  • bb
  • ccb
  • digoxin
  • clonidine
  • antiarrhythmic agents (e.g., amiodarone, lidocaine)
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8
Q

Typically, infections leads to increase in temperature with corresponding increase in heart rate. Which infections are associated with relative bradycardia?

A
  • Legionella
  • Pscittacosis
  • Q fever
  • Typhoid fever
  • Typhus
  • Babesiosis
  • Malaria
  • Leptosporiasis
  • Yellow fever
  • Dengue fever
  • Viral hemorrhagic fevers
  • Rock Mountain spotted fever
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9
Q

How often is Mobitz II AV block associated with a wide QRS?

A

Wide: 80%
Narrow: 20%

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10
Q

ECG diagnosis of STEMI?

A
  • > 0.1 STE in 2 contiguous leads
  • EXCEPT in V2-3 - must be >0.2 (men) and >0.25 (women)
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11
Q

What is the typical evolution of ECG changes associated with ischemia?

A
  • Hyperacute: tall T waves
  • Acute: STE
  • Hours: STE + reduced R wave + Q wave
  • Day 1-2: TWI, Q-wave deeper
  • Days: ST normalizes, TWI
  • Weeks: ST/TW normal, Q wave persists
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12
Q

Which conditions make ECG interpretation of ischemia unreliable?

A
  • early repolarization
  • LVH
  • LBBB
  • ventricular paced rhythm
  • preexcitation
  • J-point elevation syndromes (e.g., Brugada)
  • pericarditis/myocarditis
  • SAH
  • hyperK+
  • stress CM
  • cholecystitis
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13
Q

Risks associated with acute aortic dissection?

A
  • male
  • age: >60
  • HTN
  • prior cardiac sx (esp AV repair)
  • bicuspid AV
  • connective tissue (eg., marfan)
  • aortitis (eg., GCA, syphilis)
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14
Q

Why do MVP patients who undergo repair can oftenhave persistent episodes of chest pain + palpitations after repair?

A

Autonomic dysfunction that persists after repair

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15
Q

Definitive diagnostic study for pulmonary hypertension?

A
  • Gold: right heart cath
  • Other: TTE, ECG, PFT
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16
Q

S3 vs S4?

A

1) S3
- early diastolic
- r/t rapid ventricualr filling
- DDx: ADHF, DCM, thyrotoxicosis, AR

2) S4
- late diastolic
- r/t late atrial kick against stiff ventricle
- DDx: HTN, AS, cor pulm, ischemic CM, acute MI

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17
Q

Heart failure symptoms: R vs L?

A

1) Right
- tachycardia
- low bp
- high JVP
- RV heave
- right-sided gallop
- ascites
- LE edema

2) Left
- weakness
- crackles, orthopnea, PND
- tachycardia
- low bp
- narrow PP
- left-sided gallop
- laterally displaced apical pulse
- pulsus alternans (end stage)
- cool extremities

18
Q

What is the definition of ischemic CM?

A

LV dysfunction with at least 1 of the following:
- Hx prior MI or PCI
- >75% stenosis of LM or LAD
- 2 vessels or more with >75%

19
Q

What proportion of patients with acute myocarditis will go on to develop chronic heart failure?

20
Q

When does peripartum CM usually present?

A
  • 80% present <3 months of delivery
  • 10% during last month of pregnancy
  • 10% present 4-5 months postpartum
21
Q

What nutritional deficiencies are associated with HFrEF?

A

Thiamine, carnitine, selenium, zinc, copper

22
Q

Which extra heart sound commonly associated with HFpEF?

A

S4 (concentric - stiff ventricle)
S3 (overload - typically HFrEF)

23
Q

Toxic causes of heart failure?

A
  • Alcohol
  • Cocaine
  • Amphetamines
  • Anthracycline (chemo; Doxorubicin)
  • Thyrotoxicosis
24
Q

What threshold of alcohol consumption is associated with the development of cardiomyopathy?

A

Risk increases if consume >90g of EtOH (7-8 drinks) per day for >5 years

25
Which are the main categories that cause HFrEF?
1. Cardiovascular 2. Toxic 3. Infectious 4. Other
26
Sepsis-associated cardiomyopathy typically resolves within? Management specifics?
- 7-10 days - Same as sepsis w/o CM, with careful attention to volume status
27
What TTE finding is characteristic of Takotsubo?
- Apical ballooning - Basilar hypokinesis
28
How common is idiopathic dilated cardiomyopathy?
~1/2 of all dilated CM cases remain idiopathic
29
Quick Answers: 1. "Silent killer" 2. Right-sided heart failure 2/2 lungs 3. Associated with hypertrophic CM 4. Brachial-femoral pulse delay + rib notching on CXR
1. HTN 2. Cor pulmonale 3. HOCM 4. Coarctation of aorta
30
What is the final common pathway of all processes that lead to cor pulmonale?
Pulmonary HTN
31
Valvular lesions: which is typically associated with concentric hypertrophy in HFpEF vs. eccentric hypertrophy and HFrEF? Bonus: right-sided valvular lesions, both stenotic/regurgitant, are generally HFpEF or HFrEF?
- Stenotic - Regurgitant - HFpEF
32
Describe murmurs: 1. AS 2. MS 3. TR 4. PS 5. TS 6. PR
1. Late-peaking crescendo-decrescendo SEM at RUSB radiating into carotids - musical quality at apex "Gallavardin phenonmenon" 2. Low-pitched rumbling DEM with presystolic accentuation 3. Holosystolic murmur at LLSB, increases with inspiration (Carvallo's sign) 4. Similar to AS, but (+) Carvallo's 5. Late DEM with (+) Carvallo's 6. Decrescendo DEM with (+) Carvallo's
33
TTE criteria for severe AS?
- aortic jet velocity >4.0m/s, or - Ao >40mmHg - AVA usually <1cm2 (not required)
34
Why is mitral stenosis often associated with embolic events? (eg., stoke, renal infarct)
- Often associated with afib (>50% cases) - Risk of embolic events in valvular afib is higher than afib alone
35
Which characteristic finding of IJ waveform associated with severe TR?
- Lancisi's sign: severe TR causes C wave to fuse with V forming a prominent wave - Carvallo's sign also present (worsen with inspiration)
36
Bullet Q's - Infiltrative causes of HFpEF: 1. Middle-aged man with macroglossia + large shoulders? 2. Granulomatous disease 3. Infiltration of metallic element 4. Generalized lymphadenopathy + high LDH 5. Infiltration of "acid-loving" cells
1. Amyloidosis 2. Sarcoidosis 3. Iron overload 4. Lymphoma 5. Eosinophilia
37
How does lymphoma cause heart failure symptoms?
Pericardial infiltration + effusion
38
What is Löffler endocarditis?
**Eosinophilic myocarditis**: - Endocardial fibrosis in association with hypereosinophilic syndrome (HES) [defined as persistent hyperE with eosinophil count >1,500/microL for >6mo with evidence of organ damage
39
What is Fabry's disease?
Genetic cause of HFpEF - X-linked lysosomal storage disorder releated to deficiency of enzyme a-galactosidase A
40
2 signs that are seen in constrictive pericarditis?
1. Kussmaul's: paradoxical increase in JVP with inspiration 2. Friedreich: sharp + deep Y descent
41
How does scleroderma affect the heart and lead to heart failure?
- cor pulmonale from pHTN - acute constrictive pericarditis - pericardial effusion - premature CAD - myocarditis - nonbacterial thrombotic (marantic) endocarditis - conduction system abnormalities