Cardiology Flashcards
What is the dose of adrenaline for children and adults in CARDIAC ARREST?
Child
10micrograms every 3-5mins
1:10,000
Adult
1mg every 3-5
1:10,000
How do you treat an overdose of apixaban or rivaroxaban (DOACs)?
Andexanet alfa
What are the vitamin K clotting factors?
2, 7, 9 and 10
What is the Bainbridge reflex?
Pee more and tachycardia to push fluid out
What time during the day should you give statins?
in the evening as they make you tired
What drug can you not give to patients who have mechanical heart valves? What do you use instead?
DOACs as could cause stroke + bleeding
USE WARFARIN
What is the major haemorrhage protocol?
2222
get blood pack:
X4 Blood, X4 FFP
take U+E, FBC, Crossmatch, PT, APTT, Fibrinogen, ABG, Calcium, Lactate
1:1
blood : FFP
1g Tranexamic Acid over 10 minutes, then 1g over 8 hours
give vitK for warfarinised patients
prevent hypothermia: bear hugger blankets
How would you diagnose a carotid bruit and what could it indicate?
using a doppler ultrasoundcould lead to a clot in the carotid artery –> stroke
What is the antidote for heparin?
Protamine sulfate
How do you treat hypertension?
any ACE inhib e.g. ramipril or ARB e.g. losartan (with or without diabetes)
but if 55 or over, OR!!! Black African/African-Caribbean, NOT WITH DIABETES, first line is a calcium-channel blocker e.g. verapamil or amlodipine
if Black and T2 diabetes = losartan
-if already on ACE and calcium channel blocker ADD a thiazide LIKE (NOT BENZTHIAZIDE)
-if still not working and potassium is more than 4.5 then add an alpha or beta blocker and if it’s lower than 4.5 give spironolactone
Remember that calcium channel blockers cannot be used in heart failure apart from amlodipine
What CHADS-VASc score indicates use of oral anticoagulants?
2 or more
(Age or stroke gives a score of 2, everything else scores 1)
congestive heart failure, hypertension, age (more than or equal to 75 would give a score of 2), diabetes, stroke, vascular disease, age normal (65-74), sex (women score 1)
When would you give a blood transfusion?
if Hb is 70g/L or below
How do statins work and when do you need to stop them?
Inhibiting cholesterol synthesis.
STOP them when macrolide abx have started e.g. clarithromycin
How do you treat acute atrial fibrillation?
IN THIS ORDER:
rhythm control = DC cardioversion (first line only if symptoms less than 48 hrs or on anticoags)
Stroke control = DOAC’s !!! e.g. apixaban if CHADVASC score 2 for 4 weeks or for a minimum of 3 weeks before the cardioversion or transoesophageal echo instead of the 3 weeks anti-coag
rate control = beta blocker OR calcium channel blocker e.g. diltiazem, digoxin
if already on a beta blocker and need another rate control:
-Amiodarone (especially if they have heart disease)
-Flecainide
How do you reverse warfarin?
Reversal in 1 hr: give PCC (prothrombin complex concentrates)
-only use fresh frozen plasma if PCC is not available
-give IV vitamin K with the PCC/FFP as well
reversal in 4-24 hours: IV or oral Vit K
What is endocarditis/criteria to diagnose?
DUKE’s CRITERIA
infection of the inner lining of the heart (the endocardium)–> flu/infection like symptoms, chest pain when breathing
fever and a new murmur
janeway lesions
THREE sets of blood cultures
treatment:
normal valve—> amox +/- gent
prosthetic —> vanc + rifampicin + gent
What might suggest an:
aortic stenosis
aortic regurgitation
mitral regurgitation
mitral stenosis?
-Reduced or absent S2/ejection systolic murmur
-Early diastolic murmur
-pan-systolic murmur
-Mid-late diastolic murmur: LOUD S1: rheumatic fever
start end
MR AS systolic
AR MS diastolic
What drug is used to treat 3rd degree heart block/overdose of beta-blockers?
Atropine
How do you treat acute and chronic heart failure?
ACUTE:
1) IV furosemide
2) oxygen
3) nitrates (with caution)
4) CPAP for patients with respiratory failure
5) inotropes if have hypotension e.g. dobutamine
CHRONIC:
1) ACE-inhib
2) beta blocker
3) spironolactone
4) SGLT-2 inhibs e.g. dapagliflozin
5) ivabradine if sinus rhythm
6) valsartan
7) digoxin if in AF
8) annual influenza and one off pneumococcal
What is the DeBakey classification and the different treatments for them?
Types of aortic dissection
Type I = ascending aorta, aortic arch, descending aorta
type II = ascending aorta = IV labetalol + surgery
type III = descending aorta = IV labetalol
What drug must you stop giving if the patient has a blood clot?
naproxen or any NSAIDs as they can cause bleeding
What is an aortic dissection?
aortic aneurysm (abdominal or mediastinal) is painless until it dissects
-weak carotid, brachial and femoral pulses
-variation in arm BP
-pulsating feeling in your stomach
-persistent back pain
-persistent abdominal pain
-clammy, tachy, SOB, dizzy, TLOC
-In men, the pain can also radiate down into the scrotum
diagnose with ultrasound or if a dissection use a CT angiography
May see mediastinal widening on chest x-ray
-if tear is bigger than or 5.5cm then surgery and see specialist in 2 weeks if clinically well otherwise
-if not then regular scans to keep an eye on it-surgery if it is rapidly enlarging
-rescan in 3months if enlarging slowly
-rescan once a year if 3-4.4cm
-medications to reduce BP and cholesterol level
Acute management:
-ABCDE assessment
-Call senior
-2222- call
-2 large bore cannulas- Fluid/blood resus
-high flow oxygen
-labetalol
-analgesia
-anti-emetic
-take bloods: FBC, CRP, CK, troponin, U+Es (renal failure), glucose, Lactate- end organ damage, blood gas, group and save
What monitoring does heparin need?
APTT
How does warfarin work?
What kind of monitoring does warfarin need, side effects and drugs that might interfere?
Inhibits epoxide reductive preventing the reduction of vitamin K (blocks vitamin k from making clotting factors)
INR monitoring
warfarin—> increases prothrombin time
If INR>4.5 can’t give warfarin
Side effects:
Haemorrhage, teratogenic (CAN be used in breastfeeding), purple toes, skin necrosis
Drugs interfere:
P450 enzyme inhibitors e.g. ciprofloxacin, omeprazole, SSRIs
Cranberry juice
NSAIDs
What is Commotio Cordis?
blunt, non-penetrating trauma to the chest at the upstroke of the T wave in the cardiac cycle causing cardiac arrest and sudden death –> defibrillate
young, males
What is Buerger’s disease (thromboangiitis obliterans) and what is the difference between this and Peripheral arterial disease (PAD)?
Vessel vasculitis strongly associated with smoking
It causes Raynaud’s phenomenon (discolouration of extremities with cold exposure) and pain in legs which occurs during exercise and is relieved by rest
Peripheral arterial disease (PAD) may cause leg pain with strenuous exercise, but is not commonly associated with Raynaud’s phenomenon. PAD increases progressively with age, mostly beginning after age 40.
How do you treat a STEMI? acute and long term?
MONA
-oxygen if less than 94%
-don’t give GTA if hypotensive
1) always give 300mg aspirin
2) PCI (or fibrinolysis if PCI not possible in 2hrs)
3) give prasugrel with aspirin if not already taking oral anticoagulants or clopidogrel with aspirin if taking an oral anticoag
4) Give unfractionated heparin with bailout GPI for radial access
5) if did fibrinolytic give anti-thrombin at same time and then give ticagrelor and repeat ECG 60-90mins later
6) if no PCI then give ticagrelor
Long term:
Aspirin
ACE-inhibitor
Beta-blocker
Statin
When should a statin be perscribed?
when there is a QRisk score of >10%
How do you treat stable angina?
episodes of angina attacks = GTN spray or isosorbide mononitrate (IM)
- use asymmetric dosing interval for IM
treating stable angina = beta blocker (CANNOT USE THIS IF PATIENT HAS ASTHMA) or a calcium channel blocker and combine the two if monotherapy doesn’t work
CC monotherapy: verapamil
CC combination: amlodipine, nifedipine
prevention of stable angina (LONG TERM)= aspirin and statin OR aspirin + statin with an ACE-inhib if also have diabetes
if drugs do not work = CABG or PCI
What drug can cause angioedema (swelling, usually around the eyes, lips, tongue)?
ACE inhibitors e.g. Ramipril
What are the usual warfarin ranges?
1.1 or less = normal
2-3 = on warfarin
What does hypothermia look like on an ECG?
ST-elevation
J waves or Osborn waves
torsades de pointes
What is superficial thrombophlebitis?
inflammation associated with thrombosis of one of the superficial veins, usually the long saphenous vein of the legtreat with NSAIDs
How does metronidazole affect anticoagulants (e.g. warfarin) if taken together?
increases the anticoagulant effect
What can be seen on an ECG that would suggest a pulmonary embolism?
‘S1Q3T3’ - large S wave in lead I, a large Q wave in lead III and an inverted T wave in lead III
right bundle branch block and right axis deviation
sinus tachycardia
When should warfarin, heparin and DOACs be stopped before surgery and started again?
warfarin - 5 days before and resumed on the evening of/morning next day (if emergency then give vit K)
heparin - stopped 24hrs before and not restarted until 48hrs after
DOACs - 24hrs before for low risk procedure and 48-72hrs for high risk
What is used to treat torsades de pointes?
IV magnesium sulphate
How do you treat SVT (supraventricular tachycardia), acute and chronic?
acute management:
-vasovagal maneouvre but if systolic BP<90 then shock first
-IV 6mg adenosine (can cause chest pain)–> 12mg –> 18 mg UNLESS have asthma then use verapamil
Prevention of episodes:
beta-blockers
radio-frequency ablation
What is a normal PR interval?
0.12-0.2 seconds
How do you calculate heart rate on an ECG?
300/ (number of large boxes between two R waves)
Can you have sex after a heart attack?
Yes, when you feel ready to usually around 2-4 weeks after
When does tripe A screening happen?
SINGLE abdominal ultrasound for MALES aged 65
What is the treatment for high INR?
INR 5-8 no bleeding = withhold 1 or 2 doses of warfarin
INR 5-8 bleeding = stop warfarin, give IV vit K 1-3mg, restart when INR < 5
INR > 8 no bleeding = stop warfarin, give oral vit K 1-5mg, restart when INR < 5
INR > 8 minor bleeding = stop warfarin, give IV vit K 1-3mg, restart when INR < 5
Major bleed e.g. head injury, surgery = stop warfarin, give IV vit K 5mg, PCC
How do you remember the classes of antiarrhythmic drugs?
Some Block Potassium Channels
What specific protein can be looked at to try and diagnose heart failure?
B-type natriuretic peptide
What side effect can taking statins have and what would you do?
Muscle aches and RHABDOMYOLYSIS –> check creatinine
What are varicose veins?
dilated superficial veins usually in the legs
risk factors: old age, pregnancy, females, obesity
ultrasound will show retrograde venous flow
-leg elevation, weight loss, exercise and compression stockings
-refer to secondary care if pain, eczema or ulcer
-ablation, foam sclerotherapy, surgery (ligation)