Cardiology RACP MCQs Flashcards
(107 cards)
RACP 2022a Q28.
Which of the following drugs has cardiovascular mortality benefit in heart
failure with preserved fraction?
a. ACE inhibitior and neprolysin inhibitor
b. Angiotensin receptor blocker
c. Beta blocker
d. Sodium glucose transport 2 inhibitors
Answer D: SGLT2i
RACP 2022a 37.75M presents in heart failure. Previous unilateral carpal tunnel release. He has a mild normocytic anaemia eGFR 56 No abnormality on electrophoresis
Elevated kappa and lamda chains but kappa lamda ratio not elevated.
Pyrophosphate bone scan shows elevated uptake in the heart muscle relative
to vertebrae What is the most likely cause
a. Beta microglobulin
b. AL
c. AA
d. ATTR
Answer D ATTR
RACP 2022a Q 7
Patients with Noonan’s syndrome typically have wide spaced eyes, webbed neck and widely spaced nipples. What is the most common cardiac issue associated with Noonan’s Syndrome?
a. AS
b. MR
c. PS
d. TR
Answer C: PS
RACP 2022a Q38.
29F presents with several weeks of dizziness upon standing. Supine BP
122, standing 124. Heart rate is 90 supine, 128 standing. ECG shows sinus tachycardia What is the most likely cause?
a. Addison disease
b. Panic disorder
c. POTS
d. Hereditary sensory and autonomic neuropathy
Answer C POTS
RACP 2022a 40. Asymptomatic young-ish man with bicuspid aortic valve and aortic root dilatation. No other risk factors. What is the threshold of aortic root dilatation before surgery is needed?
a. >45mm
b. >50mm
c. >55mm
d. >60mm
Answer C > 55 mm
If bicuspid valve with RF then 50 mm
Indications for surgery:
- Ascending aorta diameter > 55 mm
- in Marfan’s / Loeys Dietz > 45 mm
- in bicuspid valve with RF > 50 mm
RACP 2022a Q87.EMQ: Which of the following causative organisms of infective endocarditis is
associated with bowel cancer?
a. Coxiella burnetti
b. Strep gallolyticus
c. Haemophilus influenza
d. Acetinobacter Baumanii
e. Staph aureus
f. Aspergillus
Answer B: Strep gallolyticus
RACP 2022a Q88.EMQ: Which of the following causative organisms of infective endocarditis is
culture negative?
a. Coxiella burnetti
b. Strep gallolyticus
c. Haemophilus influenza
d. Acetinobacter Baumanii
e. Staph aureus
f. Aspergillus
Answer A: Coxeilla burnetti
RACP 2022b Q14.
Where does the right bundle traverse after interventricular septum?
A. Perimembranous septum
B. Chordae tendinae
C. Papillary muscle
D. Moderator band
Answer D: Moderator band
RACP 2022b 30. Neonatal heart block is associated with antibodies anti-Ro/SSA and anti-La/SSB.
What period of gestation does neonatal heart block develop?
A. 12-18 weeks
B. 18-24 weeks
C. 24-30 weeks
D. 30-36 weeks
Answer B: 18-24 weeks
RACP 2022b 35.
Which sign is suggestive of aortic root abscess in endocarditis?
A. J point depression
B. PR prolongation
C. ST elevation
D. T wave inversion
Answer B: PR prolongation
RACP 2022b Q54.
What serum marker is increased with commencing of angiotensin receptor-
neprilysin inhibitors (ARNI)?
A. BNP
B. NT-proBNP
C. ADH
Answer A: BNP
The precursor proBNP is not directly affected by angiotensin receptor-neprilysin inhibitors (ARNI) such as sacubitril/valsartan because ARNI primarily inhibit neprilysin, an enzyme that degrades several vasoactive peptides, including B-type natriuretic peptide (BNP) but not its precursor proBNP or its cleavage product NT-proBNP.
Here’s why proBNP (and NT-proBNP) remains normal while BNP rises with ARNI use:
1. BNP and NT-proBNP are generated from the same precursor, proBNP: * The heart secretes proBNP, which is then cleaved into two products: the active hormone BNP and the biologically inactive fragment NT-proBNP. * ARNI inhibits neprilysin, leading to reduced degradation of BNP, thereby increasing circulating BNP levels. 2. Neprilysin doesn’t degrade proBNP or NT-proBNP: * Neprilysin is responsible for breaking down active BNP, not proBNP or NT-proBNP. Therefore, ARNI does not affect the levels of proBNP or NT-proBNP, as they are not neprilysin substrates. * This is why proBNP synthesis and cleavage continue as usual, and proBNP (and NT-proBNP) levels remain normal in patients on ARNI therapy. 3. Clinical relevance: * NT-proBNP levels are often preferred over BNP for monitoring heart failure in patients on ARNI, as NT-proBNP is unaffected by neprilysin inhibition, giving a clearer picture of heart failure severity or response to treatment.
In summary, since neprilysin does not degrade proBNP or NT-proBNP, their levels remain stable, while BNP increases due to reduced degradation.
RACP 2021 Q3.
A 54 year old man has severe aortic regurgitation on echocardiogram. He has no cardiac symptoms. What feature in echocardiogram would be the strongest indication for AV replacement?
A. Anterior mitral valve leaflet fluttering
B. Holodiastolic reversal of flow
C. LVEF <50%
D. LVEDD <65
Answer C : Heart failure LVEF < 50%
Indications for AR surgery:
- LVEF < 50%
- LVESD > 50 mm
- concomitant CABG
- severe symptomatic AR
Q30. What causes a capture beat on an ECG showing VT?
A. Sinus and ventricular activity fuse to form a hybrid complex
B. The distance from QRS to nadir S wave >100s
C. Sinus node firing causes ventricle to produce a normal QRS
D. A rabbit ear RSR shape where left ear larger than right ear
Answer C: Capture beat shown here - normal ventricular beat after sinus node firing
RACP 2021 Q74.
A 72 year old man has a history of AF and is known to be a fast CYP2D6 metaboliser with a history of previous codeine toxicity. Which rate control agent will be expected to have an expected increased dose, given the pharmacogenetics?
A. Amiodarone
B. Metoprolol
C. Digoxin
D. Verapamil
Answer B: Metoprolol
RACP 2021 Q77.
A 76 year old male presents with 24 hour history of chest pain. His ECG shows an evolving anterior MI. The
next day he has a new diastolic murmur. An urgent TTE demonstrates a VSD. He is hemodynamically stable. What is the best option for management of his VSD?
A. Medical management
B. Balloon pump
C. PCI
D. Surgical repair of VSD
Answer D: Surgical repair
RACP 2021 Q146.
What drives the process of carditis in acute rheumatic fever?
A. Bacterial infection
B. Endotoxin release
C. Exotoxin release
D. Molecular mimicry
Answer D: Molecular mimicry
RACP 2021 Q150.
What is the most common manifestation of cardiac sarcoidosis?
A. Heart failure
B. Heart block
C. Pericarditis
D. Valvular dysfunction
Answer B: CHB
RACP 2021 Oct Q2.
ECG showing electrical alternans. What condition would you see this in?
a. Pleural effusion
b. STEMI
c. Pericardial effusion
d. Atrial fibrillation
Answer C: Pericardial effusion
RACP 2021 Q17.
When can you drive after pacemaker insertion?
A. 1 day
B. 3 days
C. 7 days
D. 2 weeks
E. 1 month
F. 2 months
G. 3 months
H. 6 months
Answer D - 2 weeks
RACP 2021 Oct Q18. When can you drive after cardiac arrest?
A. 1 day
B. 3 days
C. 7 days
D. 2 weeks
E. 1 month
F. 2 months
G. 3 months
H. 6 months
H - 6 months
RACP 2021 Oct Q25.
What is the most common side effect of ticagrelor that leads to it needing to be ceased?
a. Diarrhoea
b. Nausea
c. Dyspnoea
d. Dizziness
Ans C Dyspnoea
RACP 2021 Oct 29. What is the main anatomical finding on complex transposition of the great
arteries?
a. Overriding aorta
b. left superior vena cava
c. Ventricular aortic discordance
d. Pulmonary communicating artery
Answer C Ventricular aortic discordance
RACP 2021 Oct 41. Dabigatran affects testing of which lupus antibody procoagulant
a. lupus anticoagulant
b. beta 2 microglobulin
c. anti cardiolipin
d. anti thrombin
Answer A
RACP 2021 Oct Q47. Hypertrophic cardiomyopathy, rash, nephrotic syndrome
a. Fabrys Disease
b. Sarcidosis
c. Lyme disease
d. Lupus
Ans A Fabry’s disease
Fabry’s Disease is a rare genetic disorder caused by a deficiency of the enzyme alpha-galactosidase A, leading to the buildup of globotriaosylceramide (Gb3) in various tissues. This accumulation can affect multiple organs, leading to a range of symptoms, including:
Hypertrophic cardiomyopathy (HCM): The most common cardiac manifestation in Fabry’s Disease is hypertrophic cardiomyopathy, which results from the deposition of Gb3 in the heart muscle.
Rash: Patients often develop a characteristic angiokeratoma, which is a rash consisting of small, dark red to blue spots commonly found on the skin, especially in the lower abdomen, buttocks, and thighs.
Nephrotic syndrome: Kidney involvement in Fabry’s Disease can lead to nephrotic syndrome, which manifests as proteinuria, edema, and low albumin levels.