Cardiopharmacology Flashcards Preview

Pharmacology > Cardiopharmacology > Flashcards

Flashcards in Cardiopharmacology Deck (36)
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1
Q

Methyldopa

A

MOA: alpha 2 agonist
Use: HTN in Pregnancy
AE: Direct Coombs+ hemolysis, SLE-like syndrome
DDI: TCA decreases effects (Direct Opposition)

2
Q

B-Blockers and MI?

A

Decreases Mortality

3
Q

B-Blockers in SVT?

A

Metoprolol and esmolol

Class II anti-arrhythmic

4
Q

Which B-Blockers are Beta 1 selective?

A

A-M

5
Q

Which B-Blockers are Non-selective?

A

N-Z

6
Q

Acebutalol and pindolol

A

MOA: partial B agonist
No change in Blood lipid
Can Bronchodilate

7
Q

Propanolol

A

Use: 1. CNS=>Sedation 2. inhibits deiodination

8
Q

B-Blockers AE?

A
Cardiovascular depression (Heart Block)
Increased LDL and TGs
9
Q

Propanolol Use?

A

Use: 1. CNS=>Sedation 2. inhibits deiodination

10
Q

With B-Blockers, watch out in people with what diseases?

A

Asthma, Vasospastic disorders, DM (masks hypoglycemia)

11
Q

Hydralazine MOA?

A

MOA: dilates arteries (cGMP smooth muscle relaxation via NO)

12
Q

Hydralazine AE?

A

AE: SLE-Like Syndrome (high protein binding)

13
Q

Are Hydralazine and methyl dopa safe to use in pregnancy? What else should be added to these drugs?

A

Yes; Diuretics (HCTZ)

14
Q

What is DOC IV of Hypertensive emergency?

A

Nitroprusside

15
Q

Nitroprusside AE? What is the problem with the AE? What can you give together to stop this problem?

A

CN toxicity=>binds to complex 4 of ETC
Nitrites=>methemoglobinemia Hb (Fe3+)=>binds to CN and releases O2
Thiosulfate=>binds to CN

16
Q

Verapamil/Diltiazem

A

MOA: non dihyropyridine CCB blockers in Heart (verampil=ventricles)
AE: Hyperprolactinemia (verapamil) and AV Block, Constipation (verapamil)

17
Q

Nifedipine and other “dipines” MOA? AE?

A

MOA: Blocks L-type Ca2+ channels in peripheral vascular smooth muscle=>vasodilate
AE: Gingival hyperplasia, Raynaud Phenomenon

18
Q

What drugs can be used in HTN of pregnancy?

A

Hydralazine, Labetalol, methyldopa, nifedipine

19
Q

HTN with DM and HF, DOC?

A

ACE inhibitors and ARBs

20
Q

HTN with Angina and Post MI? DOC?

A

B-Blockers

21
Q

HTN with BPH?

A

Alpha blockers

22
Q

What are the Class IA antiarrhythmics?

A

Quinidine, Procainamide, Disopyramide

23
Q

Quinidine MOA? AE?

A

MOA: Blocks Fast Na+Channels, Increases AP duration and ERP
AE: Cinchonism=Headache and tinnitus; Torsades de pointes

24
Q

Procainamide MOA? AE?

A

MOA: Blocks Fast Na+Channels, Increases AP duration and ERP
AE: Reversible-SLE like syndrome; Torsades de pointes

25
Q

Disopyramide MOA? AE?

A

MOA: Blocks Fast Na+Channels, Increases AP duration and ERP
AE: Heart Failure; Torsades de pointes

26
Q

Class IA antiarrhythmics and digoxin?

A

Displaces digoxin

27
Q

Procainamide MOA? Use? Metabolism? AE?

A

MOA: Blocks Fast Na+Channels, Increases AP duration and ERP
Use: WPW
Metabolism: N-acetyltransferase
AE: Reversible-SLE like syndrome; Torsades de pointes

28
Q

Class IA antiarrhythmics and digoxin?

A

Displaces digoxin

29
Q

What are the Class IA antiarrhythmics?

A

Quinidine, Procainamide, Disopyramide

30
Q

Quinidine MOA? AE?

A

MOA: Blocks Fast Na+Channels, Increases AP duration and ERP
AE: *Cinchonism=Headache and tinnitus; Torsades de pointes

31
Q

Procainamide MOA? Use? Metabolism? AE?

A

MOA: Blocks Fast Na+Channels, Increases AP duration and ERP
Use: WPW
Metabolism: N-acetyltransferase
AE: *Reversible-SLE like syndrome; Torsades de pointes

32
Q

Class IA antiarrhythmics and digoxin?

A

Displaces digoxin

33
Q

What are the Class IB antiarrhythmics?

A

Lidocaine, Mexiletine (Buy Liddy some Mexican Tacos)

34
Q

Lidocaine/Mexiletine MOA? AE?

A

MOA: Block inactivated Na+ channels in ischemic tissue=>prevents firing of new action potentials; Blocks Na+ slow window currents=>decreased action potential duration
Use: Post MI and Digoxin Toxicity
AE: Least Cardiotoxic
Mexiletine=Oral

35
Q

Class IC drugs?

A

Flecainide and Propafernone

36
Q

Flecainide/Propafernone

A

MOA: Blocks all Na+ channels

Proarrhythmic (contraindicated in ischemic heart disease)