Cardiovasc

Question 1

Spironolactone

Answer 1

Aldoesteron Antagonist. HF. Refractory oedema. Primary hyperaldosteronism. Hirsutism in females
25-200mg d

Question 2

Ivabradine

Answer 2

Other anti-anginals. HF. Stable Angina. 2.5-7.5 bd.
ECG. HR.
Transient areas of enhanced brightness (phosphenes) in the visual field are common, especially in the first 2 months of treatment, and usually resolve spontaneously
CC. L18. SOB - Dizzy

Question 3

Nicorandil

Answer 3

Other anti-anginals. 5-20mg bd.
Can cause large painful ulcer
headache.

Question 4

Hydrochlorothiazide

Answer 4

Hypertension, includes combinations. Oedema associated with heart failure. 
BP. electrolytes
Hypertension, 12.5–25 mg daily.\
Oedema, 25–100 mg d
l2. mane.

Question 5

Indapamide

Answer 5

Hypertension. 1.25–2.5 mg m.

electrolyes.

Question 6

Amiloride

Answer 6

K sparring diurectic. Primary hyperaldosteronism. oedema.
5mg d.
L12. L11.

Question 7

Perhexaline

Answer 7

Other antianginals. Refractory Angina. 100-250mg d.

TDM. BGL - can cause hypos.

Question 8

Valsartan

Answer 8

HTN. HF.

40mg-320mg once daily. (*can be BD in HF)

Question 9

Varapamil

Answer 9

SVT. AF. Angina. HT. Prevention of cluster headaches.\
160-240mg d CR>
May increase the affect of alcohol. l18. constipation. bradycardia.
80mg BD-TDS of conventional tablets

Question 10

Amiodarone

Answer 10

Treatment and prophylaxis of serious tachyarrhythmias
200mg tds 7/7 followed by 200 mg bd 7/7. Usual dose: 100-200mg d.
Therapeutic range 1–2.5 mg/L
Chest Xray. Thyroid Function. Coneral microdeposists. ECG.Hepatic
Taste disturbance. Constipation. L8. L18.

Question 11

Digoxin

Answer 11

Af. HF. 62.5-250mcg d.
TDM 0.5–2 microgram/
renal function. electrolyte concentrations. ECG.
Toxicity: : fatigue, blurred vision, change in color vision (Yellow)
L5

Question 12

Flecainide

Answer 12

50-200mg bd. AF.
ECG - worsen arrythmia. TDM. 0.2–0.9 mg/L.
May affect your vision

Question 13

Sotolol

Answer 13

160mg bd.

Sotalol may cause dizziness, drowsiness or visual disturbance;

Question 14

Simvastatin

Answer 14

10–40 mg once daily. Creatine kinase. Dark urine. musle weakness.

Question 15

Cholestyramine

Answer 15

Bile acid binding resin.
mixed hyperlipidaemia. Itch associated with partial biliary tract obstruction
4mg bd.
Mix with juice. Stand for four - overnight to reduce grittiness.

Question 16

Fenofibrate

Answer 16

Dyslipidaemia associated with type 2 diabetes
Severe hypertriglyceridaemia
145mg d.
CrCl 20–60 mL/minute, 96 mg once daily.
CrCl 10–20 mL/minute, 48 mg once daily
LFT. VTE. FBC. Creatine kinase.
L8. Tell doc if urine dark brown or muscle pain.

Question 17

Gemfibrozil

Answer 17

Fibrate. 600mg bd.
Half hour before food- can take with food if GI upset.
dry mouth. headache. myaligia

Question 18

Ezetimibe

Answer 18

Other drugs for dyslipiadima.
10mg d.
muscle pain, tenderness or weakness.
headache. diarrhoea.

Question 19

Nicotinic acid

Answer 19

Hypercholesterolaemia. Pellagra.
250-1 g 3 times daily
dyspepsia. flushing
cc