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Pharmacology > Cardiovascular Drugs > Flashcards

Cardiovascular Drugs Flashcards

1
Q

What is the first line drug for Hypertension with no comorbidities?

A

Hydrochlorthiazide

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2
Q

What is the MOA of Thiazide Diuretics?

A

Inhibit Na/Cl transporter in distal convuluted tubule causing moderate diuresis and reduced excretion of Calcium

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3
Q

What are the known side-effects of Thiazide Diuretics?

A 
HyperGLUC
G- Glycemia
L - Lipidemia
U - Uricemia
C - Calcemia
and
Hypokalemic Metabolic Alkalosis
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4
Q

What is the MOA of Loop Diuretics?

A

Inhibit Na/K/2Cl Transporter in Thick Ascending Limb of Loop of Henle

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5
Q

What part of the nephron does loop diuretics act?

A

Thick Ascending Limb

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6
Q

A ‘rescue’ drug for hypertension

A

Clonidine

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7
Q

Drugs used to contorl blood pressure for Pheochromocytoma

A

Phenoxybenzamine, Phentolamine and Labetalol

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8
Q

Why was reserpine withdrawn?>

A

Causes rebound suicide

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9
Q

Drug used for hypertension and BPH

A

Prazosin

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10
Q

What is the MOA of hydralazine?

A

Alters intracellular Ca metabolism and relaxes arteriolar smooth muscles, causing vasodilation and decreases afterload

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11
Q

What is a useful side effect of Minoxidil?

A

Hypertrichosis

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12
Q

Give 2 exmaples of a Non-Dihydropyridine CCB.

A

Verapamil and Diltiazem

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13
Q

Give 5 examples of a Dihydropyridine CCB

A

Nifedipine, Amlodipine, Nicardipine, Felodipine and Nisoldipine

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14
Q

Dihydropyridine acts more on cardio or vascular?

A

Vascular

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15
Q

Non-dihydropyridine acts more on cardio or vascular?

A

Cardio

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16
Q

Calcium Channel Blockers block what specific channels?

A

Voltage-gated L-Type Calcium Channels

17
Q

What is the dreaded side-effect of Nitroprusside?

A

Cyanide Toxicity

18
Q

A dopamine agonist used for hypertensitve emergency

A

Fenoldopam

19
Q

What is the MOA of Clonidine?

A

Activates alpha 2 adrenergic receptors thereby decreasing central sympathetic outflow

Pharmacology (6 decks)

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