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Pharmacology > Cardiovascular-Renal Pharmacology 2 > Flashcards

Cardiovascular-Renal Pharmacology 2 Flashcards

(56 cards)

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1
Q

Hydraulic equation of Hypertension

A

BP=CO x PVR

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2
Q

Volume of blood pumped out by the VENTRICLE PER MINUTE

A

Cardiac output

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3
Q

Volume of blood pumped out by the VENTRICLE PER CONTRACTION/BEAT
(ml/beat)

A

Stroke volume

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4
Q

It is the heart conductivity

A

Heart rate

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5
Q

Determinants of stroke volume
Heart rate

A

+ Chronotrope increase HR, SV, CO, BP

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6
Q

Strength or force of contraction

A

Inotropy

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7
Q

Determinants of stroke volume
Inotropy

A

+ Inotrope increase SV, CO, BP

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8
Q

Volume of blood in the ventricles PRIOR TO CONTRACTION

A

Preload/ End diastolic volume

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9
Q

Carries blood towards the heart

A

Veins

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10
Q

Venoconstriction
Venous capacitance is
Blood is
Preload

A

Reduced
Mobilized
Increase

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11
Q

Venodilation
Venous capacitance is
Blood is
Preload

A

Increased
De-mobilized
Decrease

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12
Q

Fluid content of blood

A

Blood volume

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13
Q

Increase fluid content=

A

Increase preload (Blood is more bulky)

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14
Q

Increase Blood Volume=

A

Increase preload - stroke volume

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15
Q

Decrease venous capacitance=

A

Decrease ability of vein to contain blood

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16
Q

Peripheral vascular resistance is also known as

A

Total vascular resistance
Systemic vascular resistance
Afterload

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17
Q

Pressure required for the blood to be ejected

A

Peripheral vascular resistance

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18
Q

Resistance ventricles must overcome to circulate blood

A

Peripheral vascular resistance

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19
Q

Increase afterload
Increase BP
More harder for ventricles to pump blood

A

Arterioconstriction

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20
Q

Decrease afterload
Decrease BP

A

Arteriodilation

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21
Q

A drug that is both vaso and arteriodilator

A

Sodium nitroprusside

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22
Q

A drug that is arteriodilator

A

Amlodipine

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23
Q

Uses of BP regulation

Study These Flashcards
A

To not reach dangerous levels

24
Q

Short term mechanism of BP regulation

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A

Baroreceptor reflex

25
It detects the increase of BP
Carotid sinus baroreceptor
26
It detects the decrease of BP
Aortic arch baroreceptor
27
Carotid sinus to brain through?
Afferent nerve 9
28
Vasomotor center (brain) to execute parasympathetic action
Efferent nerve 10
29
Aortic arch to vasomotor or brain
Afferent nerve 10
30
Brain to Sympathetic action
Pre-ganglionic Sympathetic fibers
31
Increase in BP SANS/PANS
SANS
32
The long term regulation for BP
Renin-angiotensin aldosterone system
33
Final effect of RAAS activation is always?
Increase BP
34
Inhibition of RAAS steps will lead to?
Decrease in BP
35
Where is angiotensinogen synthesized?
Liver
36
Where is renin synthesized
Kidneys
37
Where is angiotensin converting enzyme synthesized
Lungs
38
Triggers of renin release
Beta-1 Stimulation Renal Hypoperfusion (Kulang sa dugo) Renal Hypotension
39
ACE degrades what substance in the lungs
Bradykinin Substance P
40
AG II binds to
AG IA receptors
41
Effects of angiotensin II binding
Stimulation of autonomic ganglia Release and synthesis of Aldosterone Release of vasopressin
42
Stimulation of autonomic ganglia is what activity
SANS activity
43
Aldosterone is hormone in the blood synthesized by
Adrenal glands
44
A main mineralocorticoid
Aldosterone
45
What does aldosterone increases
Increase sodium and water reabsorption
46
Vasopressin is what kind of hormone
Antidiuretic hormone
47
Effects of vasopressin
Vasoconstriction Prevents urination=water retention (increasing BP & BV)
48
Example of Renin Inhibitor
Aliskiren (decreases BP)
49
Example of ACE inhibitor
"-prils" - decrease BP - Accumulation of Bradykinin and substance P
50
Accumulation of Bradykinin and substance P in the lungs leads to the common side effect
Dry cough
51
Example of ARB
"-sartan"
52
MOA of ARB
Competitive blockers to angiotensin 1A
53
It is a pharmacologic antagonist
ARB
54
Agonist of angiotensin 1a
Angiotensin II
55
Have affinity and intrinsic activity
Agonist
56
Have affinity but no intrinsic activity
Antagonist

Pharmacology (5 decks)

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