Cardiovascular risk management Flashcards

(50 cards)

1
Q

indications for clinically determined high risk

A

moderate-severe kidney disease
familial hypercholesterolaemia

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2
Q

for which age groups should you use the risk calculator

A

all people aged 45-79
people with diabetes 35-79
first nations 30-79

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3
Q

modifiable risk factors on the CVD check

A

smoking
cholesterol
blood pressure

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4
Q

non modifiable risk factors on the CVD check

A

age
sex
postcode (socioeconomic)
diabetes
chronic kidney disease
familial hypercholesterolaemia
evidence of atrial fibrillation

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5
Q

people who are already at known increased risk and do not need an absolute CVD risk assessment

A

moderate or severe CKD
a previous diagnosis of familial hypercholesterolaemia

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6
Q

what are some additional factors to consider in people with diabetes

A

uACR (urine albumin:creatinine)
eGFR
BMI
HbA1c
Insulin
Time since diagnosis

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7
Q

reclassification factors

A
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8
Q

ethnicities that may raise risk

A

First Nations
maori people
pacific islander people
south asian (indian, Pakistani, bangladeshi, sri lankan, nepali, bhutanese, maldivian)

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9
Q

ethnicities that may lower risk

A

east asain (chinese, japanese, korean, taiwanese, mongolian)

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10
Q

what is coronary artery calcium score

A

performed via CT, does not require contrast or IV access
low radiation exposure, similar to mammogram
provides a score related to the amount and density of calcified plaque for each coronary artery

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11
Q

is coronary artery calcium score recommended

A

not recommended for generalised population screening for CVD risk
not covered by medicare

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12
Q

ankle brachial index

A

not used for CVD risk calculation as it provides little risk discrimination beyond existing CVD risk calculators
useful for assessing people with suspected PVD

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13
Q

high sensitivity CRP

A

non specific marker of inflammation
not used for CVD risk calculation
persistently elevated CRP in people with chronic inflammatory conditions (eg. SLE, RA, psoriasis) but no known CVD may be a useful predictor of increased risk of CVD events

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14
Q

chronic autoimmune inflammatory conditions

A

RA, systemic sclerosis, addison’s, SLE, T1DM are all asssociated with increased CVD risk but are not useful reasons to change CVD risk prediction level

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15
Q

for people <5% (low) 5-year risk

A

lifestyle measures
pharmacotherapy not usually used
reassess at least every 5 years or 2 for First Nations

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16
Q

5-9% 5-year risk

A

lifestyle measures
consider blood pressure lowering and lipid-modifying pharmacotherapy, depending on clinical context
reassess everyone at least every 2 years

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17
Q

10+% 5-year risk

A

lifestyle measures
lipid lowering and antihypertensives
formal reassessment generally not required as calculated risk is unlikely to go down

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18
Q

should these guidelines be followed rigidly

A

more about shared decision making

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19
Q

mediterranean diet

A

supportive RCTs with clinical CV outcome reduction in both secondary and primary prevention - probably the best evidence we have

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20
Q

hypertension symptoms

A

usually asymptomatic - you need to look for it
major risk factor for IHD, heart failure, stroke, renal failure
treatment lifelong

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21
Q

how to check blood pressure

A

seated, relaxed, take 3 readings and average the last two
home or ambulatory BP should be offered to reduce white coat

22
Q

hypertension thresholds

23
Q

hypertension initial evaluation

A

full Hx/PMHx/Meds etc.
end organ disease? evidence of secondary HT causes? medicines that may raise BP? anything to contraindicate certain anti-hypertensives
Ex: pulse rate/rhythm/ JVP/ cardiomegaly/failure signs, vasculopathy signs, fundi, near signs, palpable kidneys, endocrine abnormalities, BMI

24
Q

hypertension Ix

A

U&E + GFR
ACR
lipids
fasting glucose
Hb
ECG (?AF, ?LVH, ?IHD)

25
antihypertensives
in patients with uncomplicated hypertension, ACEI/ARB or CCB or thiazide diuretics are all suitable first line antihypertensive drugs, either as monotherapy or in some combinations as indicated
26
adverse effects of ACEI
cough, angioedema, postural hypotension
27
adverse effects of CCB
headache, flushing, peripheral oedema, constipation, postural hypotension
28
adverse effects of thiazides
gout, glucose, electrolyte abnormality, ED, postural hypotension less at low doses
29
examples of thiazides
chlorthalidone hydrochlorothiazide Indapemide
30
adverse effects of beta blockers
lethargy, ED, dyspnoea the balance between safety and efficacy for beta blockers is less favourable than other first line treatments for hypertension
31
combinations of anti-hypertensives that are fine
ACEI/ARB, CCB and thiazide in any combination beta blocker with most of the above
32
combinations of anti-hypertensives to avoid
beta blocker with verapamil - heart block ACEI with ARB - no benefit and more adverse events ACEI/ARB with potassium sparing diuretic - hyperkalaemia
33
costs of anti hypertensives
thiazides are the cheapest but they're all getting cheaper with generics
34
causes of refractory hypertension
- not adherent wth plan, communication/education required - dose too low - other drugs/substances - lifestyle - white coat - secondary hypertension
35
Ix for secondary hypertension
- aldosterone/renin ratio (for primary hyperaldosteronism) - 24 hour urinary cetacholemine (for pheochromocytoma) - renal artery duplex US (for renal artery stenosis) - if suspected Cushing's - dexamethasone suppression test
36
statins
lower LDL, have by far the best evidence base in terms of clinical outcomes eg.
37
ezetimibe is good for
statin alternative, also used to lower cholesterol but prevents absorption instead of acting on the liver small absolute benefit after ACS, no outcome studies in primary prevention
38
other lipid lowering medications
Ezetimibe - small absolute benefit after ACS, no outcome studies in primary prevention fibrates - lowers TG, may help in people with low HDL niacin - nicotinic acid, lower LDL fish oil/omega 3 fatty acids - lowers TG plant sterols/stanols - privent cholesterol absorption, no outcome evidence
39
side effects of statin controversies
myalgias - limited evidence severe myositis/rhabdomyolysis - associated but rare liver injury - associated but rare diabetes - risk seems outweighed by CV benefits
40
do statins cause cancer or dementia?
no
41
lipid targets
42
secondary prevention post CVA
lifestyle changes antihypertensives (any of the usual first-line drugs are good) antiplatelets - after ischaemic stroke anticoagulation - not routine unless AF statin - after ischaemic stroke consider carotid endarterectomy manage diabetes if present usually stop HRT/hormonal contraceptives
43
what kind of antiplatelet therapy do you use post ischaemic CVA
DAPT for 21 days: combination aspirin/dipyridamole (PBS) OR aspirin/clopidogrel (non-PBS) aspirin alone is an option especially if the above is not tolerated
44
should you use long term combination aspirin and clopidogrel (DAPT)
no only recommended for 10-21 days after high risk TIA or mild stroke
45
should you use a statin after a heamorhagic stroke
no
46
secondary prevention post MI
cardiac rehabilitation lifestyle changes ACE inhibitor indefinitely beta blocker (at least 12 months; indefinitely if LV dysfunction) high potency statin indefinitely aspirin indefinitely +/- another antiplatelet medication
47
which antiplatelet do you use after MI
aspirin indefinitely +/- another antiplatelet agent - clopidogrel, prasugrel or ticagrelor especially after stenting, for 12 months evidence complicated, prescribing guided by cardiologist
48
stroke prevention in AF
anticoagulation usually NOACs favoured
49
anti-hypertensives in older people
commence at low dose and titrate slowly as adverse effects increase with age, including: hypotension, syncope, electrolyte imbalance, acute kidney injury
50