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Intensive care > Cardiovascular support/drugs > Flashcards

Cardiovascular support/drugs Flashcards

1
Q

Types of inotrope

A

Catecholamines
Phosphodiesterase-3 inhibitors
Levosimendan

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2
Q

Catecholamines

A 
Adrenaline 
Noradrenaline 
Dopamine
Dobutamine (synthetic)
Isoprenaline (synthetic)
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3
Q

Phosphodiesterase inhibitors

A

Milrinone
Theophyline
(independent of adrenergic receptors)

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4
Q

Levosimendan

A

Sensitises troponin-C to calcium

Leopards trial - Gordon et al - sepsis

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5
Q

Other drugs with inotropic effects

A

Digoxin
Glucagon
Insulin

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6
Q

Negative inotropes

A 
Beta blockers 
Calcium channel blockers 
(non-dihydropyridine) 
Amiodarone 
Class 1A + 1C antiarrhythmics
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7
Q

MAP equation

A

MAP = CO x SVR

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8
Q

CO equation

A

CO = SV x HR

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9
Q

Stroke volume

A

Depends on preload and afterload

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10
Q

Vaugh Williams classification

A 
1 - Na channel blocker
a
b
c
2 - Beta blocker
3 - K channel blockers 
4 - Ca channel blockers
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11
Q

sodium channel blockers

A

VW 1
Reduce phase 0 slope and peak of action potential
1c>1a>1b

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12
Q

beta blocker

A

Block sympathetic activity

- reduce rate and conduction

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13
Q

potassium channel blocker

A 
Amiodarone, sotalol
Delay repolarization (phase 3)  and therefore increase AP duration and effective refractory period
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14
Q

Calcium channel blocker

A

Block L type calcium channel channels
- effective at SA and AV nodes
- reduce rate and conduction
Non-dihydropyridines vs dihydropyridines

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15
Q

Class 1a

A

Quinidine, procainamide, disopryamide

  • moderate Na blockade
  • increased effective refractory period
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16
Q

Class 1b

A

lidocain, tocainide, mexiletine

  • weak Na blockade
  • decreased effective refractory period
17
Q

Class 1c

A

Flecainide

  • strong Na blockade
  • no change in effective refractory period
18
Q

Digoxin

A

inhibitors of cellular Na+/K+-ATPase

19
Q

Non-dihydropyridine CCB

A

verapamil and diltiazem

20
Q

Atropine

A

muscarinic antagonist

Intensive care (2 decks)

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